Protein-DNA Interactions Regulate Human Papillomavirus DNA Replication, Transcription, and Oncogenesis.
Female
Humans
Oncogene Proteins, Viral
/ genetics
Human Papillomavirus Viruses
Papillomavirus E7 Proteins
/ genetics
Papillomavirus Infections
/ genetics
Uterine Cervical Neoplasms
/ genetics
DNA
Cell Transformation, Neoplastic
Carcinogenesis
/ genetics
Papillomaviridae
/ genetics
DNA Replication
/ genetics
E2 protein
HPV
cervical cancer
oropharyngeal cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 May 2023
09 May 2023
Historique:
received:
27
03
2023
revised:
30
04
2023
accepted:
02
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Human papillomavirus (HPV) is a group of alpha papillomaviruses that cause various illnesses, including cancer. There are more than 160 types of HPV, with many being "high-risk" types that have been clinically linked to cervical and other types of cancer. "Low-risk" types of HPV cause less severe conditions, such as genital warts. Over the past few decades, numerous studies have shed light on how HPV induces carcinogenesis. The HPV genome is a circular double-stranded DNA molecule that is approximately 8 kilobases in size. Replication of this genome is strictly regulated and requires two virus-encoded proteins, E1 and E2. E1 is a DNA helicase that is necessary for replisome assembly and replication of the HPV genome. On the other hand, E2 is responsible for initiating DNA replication and regulating the transcription of HPV-encoded genes, most importantly the E6 and E7 oncogenes. This article explores the genetic characteristics of high-risk HPV types, the roles of HPV-encoded proteins in HPV DNA replication, the regulation of transcription of E6 and E7 oncogenes, and the development of oncogenesis.
Identifiants
pubmed: 37239839
pii: ijms24108493
doi: 10.3390/ijms24108493
pmc: PMC10218588
pii:
doi:
Substances chimiques
Oncogene Proteins, Viral
0
Papillomavirus E7 Proteins
0
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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