Dynamic Evolution of Humoral and T-Cell Specific Immune Response to COVID-19 mRNA Vaccine in Patients with Multiple Sclerosis Followed until the Booster Dose.
COVID-19
SARS-CoV-2
T-cell response
antibody response
mRNA vaccines
multiple sclerosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 May 2023
10 May 2023
Historique:
received:
20
04
2023
revised:
05
05
2023
accepted:
08
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
This study characterizes antibody and T-cell immune responses over time until the booster dose of COronaVIrus Disease 2019 (COVID-19) vaccines in patients with multiple sclerosis (PwMS) undergoing different disease-modifying treatments (DMTs). We prospectively enrolled 134 PwMS and 99 health care workers (HCWs) having completed the two-dose schedule of a COVID-19 mRNA vaccine within the last 2-4 weeks (T0) and followed them 24 weeks after the first dose (T1) and 4-6 weeks after the booster (T2). PwMS presented a significant reduction in the seroconversion rate and anti-receptor-binding domain (RBD)-Immunoglobulin (IgG) titers from T0 to T1 (
Identifiants
pubmed: 37239872
pii: ijms24108525
doi: 10.3390/ijms24108525
pmc: PMC10218688
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
RNA, Messenger
0
mRNA Vaccines
0
Immunoglobulin G
0
Antibodies, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero della Salute
ID : Ricerca Corrente on emerging infections
Organisme : European Project SHARP
ID : 848096
Organisme : Camera di Commercio, Industria e Artigianato di Roma
ID : resolution number 395 on 25 May 2021
Références
Eur J Neurol. 2019 Jan;26(1):27-40
pubmed: 30300457
Clin Chem Lab Med. 2023 Apr 03;:
pubmed: 36999398
Lancet. 2021 Jul 31;398(10298):385-387
pubmed: 34274038
Mult Scler Relat Disord. 2022 Jul;63:103863
pubmed: 35667316
N Engl J Med. 2021 Dec 9;385(24):e84
pubmed: 34614326
Nat Med. 2021 Nov;27(11):1990-2001
pubmed: 34522051
EBioMedicine. 2022 Jun;80:104042
pubmed: 35526306
Mult Scler Relat Disord. 2022 May;61:103776
pubmed: 35364386
J Neurol. 2023 May;270(5):2380-2391
pubmed: 36933032
Mult Scler Relat Disord. 2023 Feb;70:104486
pubmed: 36628884
Mult Scler Relat Disord. 2022 Dec;68:104119
pubmed: 36037755
Front Neurol. 2022 May 31;13:881988
pubmed: 35711277
Science. 2021 Dec 03;374(6572):abm0829
pubmed: 34648302
J Neurol Neurosurg Psychiatry. 2023 Apr;94(4):290-299
pubmed: 36522154
BMJ. 2022 Apr 27;377:e069317
pubmed: 35477670
Cell Rep Med. 2022 Dec 20;3(12):100850
pubmed: 36450283
Front Immunol. 2022 Feb 28;13:846753
pubmed: 35309297
Blood Adv. 2022 Jun 14;6(11):3230-3233
pubmed: 35026843
Clin Microbiol Infect. 2021 Dec;27(12):1784-1789
pubmed: 34256141
Neurology. 2022 Feb 1;98(5):e541-e554
pubmed: 34810244
Lancet Rheumatol. 2022 May;4(5):e338-e350
pubmed: 35317410
JAMA Neurol. 2022 Mar 1;79(3):307-309
pubmed: 35072702
J Neurol. 2023 Jan;270(1):272-282
pubmed: 36048265
Neurol Neuroimmunol Neuroinflamm. 2022 May 6;9(4):
pubmed: 35523569
Ther Adv Neurol Disord. 2021 Apr 22;14:17562864211012835
pubmed: 34035836
Mult Scler Relat Disord. 2022 Aug;64:103937
pubmed: 35700625
Int J Infect Dis. 2022 Dec;125:195-208
pubmed: 36328289
Blood. 2004 Dec 15;104(13):4129-33
pubmed: 15319278
N Engl J Med. 2022 Sep 15;387(11):1011-1020
pubmed: 36044620
Euro Surveill. 2021 Sep;26(39):
pubmed: 34596015
Mult Scler. 2022 Nov;28(13):2106-2111
pubmed: 35735030
Mult Scler Relat Disord. 2022 Mar;59:103682
pubmed: 35158189
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Pathogens. 2022 Aug 05;11(8):
pubmed: 36015003
Nat Immunol. 2022 Feb;23(2):186-193
pubmed: 35105982
JMIR Public Health Surveill. 2022 Nov 8;8(11):e38898
pubmed: 36265135
J Neurol. 2022 Mar;269(3):1114-1120
pubmed: 34533590
Mult Scler J Exp Transl Clin. 2023 Apr 5;9(2):20552173231165196
pubmed: 37057191
Mult Scler Relat Disord. 2022 Apr;60:103729
pubmed: 35334278
Front Immunol. 2022 Apr 01;13:868915
pubmed: 35432335
JCI Insight. 2022 Feb 22;7(4):
pubmed: 35030101
Vaccines (Basel). 2023 Mar 28;11(4):
pubmed: 37112658
Cell. 2022 Mar 3;185(5):847-859.e11
pubmed: 35139340
Front Neurol. 2023 Feb 24;14:1092999
pubmed: 36908621
Science. 2022 Jan 07;375(6576):43-50
pubmed: 34812653
N Engl J Med. 2021 Oct 7;385(15):1393-1400
pubmed: 34525275
J Neurol. 2022 Dec;269(12):6185-6192
pubmed: 35879563
Clin Infect Dis. 2023 Feb 8;76(3):e426-e438
pubmed: 35607769
Nat Immunol. 2022 Jul;23(7):1008-1020
pubmed: 35761083
JAMA Netw Open. 2023 May 1;6(5):e2310650
pubmed: 37133863
Ther Adv Neurol Disord. 2013 Jul;6(4):237-48
pubmed: 23858327
Vaccines (Basel). 2023 Jan 01;11(1):
pubmed: 36679947
Int J Infect Dis. 2022 Sep;122:841-849
pubmed: 35878802
Mult Scler. 2022 Jun;28(7):1034-1040
pubmed: 34328824
JAMA Neurol. 2022 Apr 01;79(4):399-404
pubmed: 35212717
J Neurol Sci. 2022 Mar 15;434:120155
pubmed: 35091386
Mult Scler Relat Disord. 2023 Apr;72:104616
pubmed: 36933299
EClinicalMedicine. 2021 Nov;41:101143
pubmed: 34608454
JAMA. 2021 Feb 23;325(8):765-779
pubmed: 33620411
Viruses. 2021 Apr 10;13(4):
pubmed: 33920222
N Engl J Med. 2022 Jun 9;386(23):2188-2200
pubmed: 35443106
Biomedicines. 2023 Apr 23;11(5):
pubmed: 37238918
Vaccines (Basel). 2023 Apr 03;11(4):
pubmed: 37112698
Vaccines (Basel). 2023 Apr 15;11(4):
pubmed: 37112761
Int J Infect Dis. 2021 May;106:338-347
pubmed: 33864921