Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies.
CD11b
CD69
CD8+ T cell
Fyn
LAG-3
LAT
LCK
OX-40
PD-1
PD-L1
TIM-3
TLCRs
VEGFR-2
ZAP70
angiogenesis
aryl urea
benzylethoxyaryl urea
immune checkpoints
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 May 2023
11 May 2023
Historique:
received:
30
03
2023
revised:
07
05
2023
accepted:
08
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Thirteen benzylethoxyaryl ureas have been synthesized and biologically evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins to overcome resistance phenomena offered by cancer. The antiproliferative activity of these molecules on several tumor cell lines (HT-29 and A549), on the endothelial cell line HMEC-1, on immune cells (Jurkat T) and on the non-tumor cell line HEK-293 has been determined. Selective indexes (SI) have been also determined and compounds bearing
Identifiants
pubmed: 37239929
pii: ijms24108582
doi: 10.3390/ijms24108582
pmc: PMC10218498
pii:
doi:
Substances chimiques
Urea
8W8T17847W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Economía y competividad
ID : RTI2018-097345-B-I00
Organisme : Ministerio de ciencia e innovación
ID : PID2021-1267770B-100
Organisme : Jaume I University
ID : UJI-B2021-46
Organisme : Asociación Española Contra el Cáncer
ID : PRDCA18002CARD
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