Potential Role of the mTORC1-PGC1α-PPARα Axis under Type-II Diabetes and Hypertension in the Human Heart.
Humans
Rats
Animals
PPAR alpha
/ genetics
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ genetics
Hypertension
/ complications
Diabetes Mellitus, Type 2
/ complications
Myocytes, Cardiac
/ metabolism
Adenosine Triphosphate
/ metabolism
cardiomyopathy
hypertension
mTOR complexes
type-II diabetes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 May 2023
11 May 2023
Historique:
received:
27
03
2023
revised:
04
05
2023
accepted:
09
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Type-2 diabetes (T2DM) and arterial hypertension (HTN) are major risk factors for heart failure. Importantly, these pathologies could induce synergetic alterations in the heart, and the discovery of key common molecular signaling may suggest new targets for therapy. Intraoperative cardiac biopsies were obtained from patients with coronary heart disease and preserved systolic function, with or without HTN and/or T2DM, who underwent coronary artery bypass grafting (CABG). Control (
Identifiants
pubmed: 37239977
pii: ijms24108629
doi: 10.3390/ijms24108629
pmc: PMC10218005
pii:
doi:
Substances chimiques
PPAR alpha
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI18/01016 and PI20/00923
Organisme : Comunidad de Madrid and European Regional Development Fund
ID : SPACE2-CV-COVID-CM grant from REACT-EU
Organisme : Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
ID : CB07/08/2007
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