Therapeutic Potential of Targeting Complement C5a Receptors in Diabetic Kidney Disease.
complement system
diabetic kidney disease
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 May 2023
15 May 2023
Historique:
received:
04
04
2023
revised:
26
04
2023
accepted:
28
04
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Diabetic kidney disease (DKD) affects 30-40% of patients with diabetes and is currently the leading cause of end-stage renal disease (ESRD). The activation of the complement cascade, a highly conserved element of the innate immune system, has been implicated in the pathogenesis of diabetes and its complications. The potent anaphylatoxin C5a is a critical effector of complement-mediated inflammation. Excessive activation of the C5a-signalling axis promotes a potent inflammatory environment and is associated with mitochondrial dysfunction, inflammasome activation, and the production of reactive oxygen species. Conventional renoprotective agents used in the treatment of diabetes do not target the complement system. Mounting preclinical evidence indicates that inhibition of the complement system may prove protective in DKD by reducing inflammation and fibrosis. Targeting the C5a-receptor signaling axis is of particular interest, as inhibition at this level attenuates inflammation while preserving the critical immunological defense functions of the complement system. In this review, the important role of the C5a/C5a-receptor axis in the pathogenesis of diabetes and kidney injuries will be discussed, and an overview of the status and mechanisms of action of current complement therapeutics in development will be provided.
Identifiants
pubmed: 37240105
pii: ijms24108758
doi: 10.3390/ijms24108758
pmc: PMC10218149
pii:
doi:
Substances chimiques
Complement C5a
80295-54-1
Complement System Proteins
9007-36-7
Receptor, Anaphylatoxin C5a
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Biol Chem. 2019 May 24;294(21):8384-8394
pubmed: 30971430
Pediatr Nephrol. 2014 Nov;29(11):2225-8
pubmed: 24924752
Kidney Int Rep. 2017 Oct 16;3(2):302-313
pubmed: 29725633
PLoS One. 2013 Jun 13;8(6):e66305
pubmed: 23785491
J Clin Med. 2021 Mar 02;10(5):
pubmed: 33801177
J Cell Mol Med. 2021 Jan;25(2):960-974
pubmed: 33280239
Immunol Cell Biol. 2014 Aug;92(7):631-9
pubmed: 24777312
Pediatrics. 2015 Jun;135(6):e1506-9
pubmed: 25941307
J Immunol. 1999 Apr 1;162(7):4336-41
pubmed: 10201966
Lancet. 2014 Jan 4;383(9911):69-82
pubmed: 23890997
Diabetes. 2011 Sep;60(9):2354-69
pubmed: 21752957
Immunobiology. 2015 Aug;220(8):993-8
pubmed: 25982307
Front Endocrinol (Lausanne). 2023 Jan 05;13:903970
pubmed: 36686462
Brain Res Mol Brain Res. 2001 Jan 31;86(1-2):13-22
pubmed: 11165367
Nat Rev Nephrol. 2021 Mar;17(3):172-184
pubmed: 32989282
Am J Hum Genet. 2005 Jul;77(1):149-53
pubmed: 15895326
Sci Rep. 2022 Nov 24;12(1):20278
pubmed: 36434087
FASEB J. 2006 Feb;20(2):217-26
pubmed: 16449793
J Am Soc Nephrol. 2016 Jun;27(6):1727-40
pubmed: 26453613
Cell Mol Life Sci. 2018 Feb;75(4):715-726
pubmed: 28921001
Front Med (Lausanne). 2021 Jan 21;7:599236
pubmed: 33553201
Kidney Int. 2019 Jul;96(1):117-128
pubmed: 31029505
Lancet Diabetes Endocrinol. 2014 Jan;2(1):56-64
pubmed: 24622669
Int J Mol Sci. 2019 Sep 10;20(18):
pubmed: 31510052
Diabetes Metab Res Rev. 2017 Jul;33(5):
pubmed: 28303635
JCI Insight. 2020 Apr 9;5(7):
pubmed: 32191644
J Biol Chem. 2008 Nov 7;283(45):31038-46
pubmed: 18772131
Kidney Int. 2017 Nov;92(5):1071-1083
pubmed: 28890325
Front Immunol. 2020 Aug 18;11:1875
pubmed: 32973774
J Diabetes Res. 2017;2017:6368780
pubmed: 28349070
Am J Nephrol. 2022;53(10):687-700
pubmed: 36423588
Nat Med. 2018 Nov;24(11):1721-1731
pubmed: 30275566
Immunol Cell Biol. 2016 Sep;94(8):787-95
pubmed: 27108698
Nat Rev Nephrol. 2018 Jan;14(1):26-47
pubmed: 29199277
Clin Kidney J. 2022 Jan 24;15(5):922-928
pubmed: 35498891
Br J Haematol. 2019 Apr;185(2):297-310
pubmed: 30768680
Nat Rev Nephrol. 2018 Jun;14(6):361-377
pubmed: 29654297
FASEB J. 2017 Jul;31(7):3193-3204
pubmed: 28396344
J Am Soc Nephrol. 2012 Sep;23(9):1474-85
pubmed: 22797180
Mol Immunol. 2000 Jun;37(8):407-12
pubmed: 11090875
Endocr Rev. 2015 Jun;36(3):272-88
pubmed: 25859860
Nat Rev Nephrol. 2011 Oct 18;7(12):684-96
pubmed: 22009250
Nat Commun. 2017 Dec 18;8(1):2169
pubmed: 29255305
FASEB J. 2008 Apr;22(4):1065-72
pubmed: 18039928
Am J Transplant. 2014 Feb;14(2):459-65
pubmed: 24400968
Nat Rev Nephrol. 2010 Jun;6(6):319-30
pubmed: 20440277
Proteomes. 2021 Dec 13;9(4):
pubmed: 34941814
JCI Insight. 2017 Dec 21;2(24):
pubmed: 29263309
Transplantation. 2019 Nov;103(11):2397-2404
pubmed: 30801549
Immunobiology. 2012 Nov;217(11):1026-33
pubmed: 22964228
Mol Immunol. 2009 Sep;46(15):3086-98
pubmed: 19615750
Eur J Haematol. 1993 Nov;51(5):282-7
pubmed: 8282089
Mol Immunol. 2013 Mar;53(3):237-45
pubmed: 22960554
Kidney Int. 1994 Feb;45(2):451-60
pubmed: 8164433
J Invest Dermatol. 1994 May;102(5):803-6
pubmed: 7513741
J Immunol. 2013 Oct 15;191(8):4367-74
pubmed: 24043887
Am J Kidney Dis. 2015 Mar;65(3):484-9
pubmed: 25530108
Mol Cell Endocrinol. 2014 Jan 25;382(1):325-333
pubmed: 24397921
J Am Soc Nephrol. 2007 May;18(5):1508-15
pubmed: 17389734
Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1356-65
pubmed: 27053686
Diabetes Metab. 2019 Jun;45(3):248-253
pubmed: 29729954
Oncotarget. 2017 Jan 31;8(5):8590-8596
pubmed: 28052000
FASEB J. 2005 Jun;19(8):1003-5
pubmed: 15784721
Nat Rev Nephrol. 2016 Jul;12(7):383-401
pubmed: 27211870
Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2032-2045
pubmed: 28522654
Diabetes. 2004 Oct;53(10):2653-61
pubmed: 15448097
Am J Pathol. 2018 Oct;188(10):2147-2154
pubmed: 30253844
J Immunol. 2020 Aug 15;205(4):1102-1112
pubmed: 32611725
Kidney Int. 2003 Jan;63(1):225-32
pubmed: 12472787
Am J Med. 1985 May;78(5):785-94
pubmed: 3993659
Diabetes Care. 2015 Oct;38(10):1898-903
pubmed: 26180106
J Immunol. 2019 Jun 15;202(12):3339-3348
pubmed: 31160390
Transplantation. 2016 Jul;100(7):1415-24
pubmed: 26599489
Biochemistry. 2003 Aug 12;42(31):9406-15
pubmed: 12899627
N Engl J Med. 2006 Sep 21;355(12):1233-43
pubmed: 16990386
J Biol Chem. 2010 Mar 5;285(10):7633-44
pubmed: 20044484
Mol Immunol. 2009 Mar;46(6):1149-62
pubmed: 19100624
Diabetologia. 2005 Jan;48(1):198-202
pubmed: 15616805
J Diabetes. 2022 Apr;14(4):291-297
pubmed: 35322566
Front Immunol. 2019 Sep 27;10:2166
pubmed: 31611870
Kidney Int. 2016 Sep;90(3):540-54
pubmed: 27370410
J Endocrinol Invest. 2021 Dec;44(12):2709-2723
pubmed: 34043214
Cell. 2012 Sep 28;151(1):14-23
pubmed: 23021212
Aging (Albany NY). 2019 Jul 8;11(13):4382-4406
pubmed: 31284268
Mol Immunol. 2018 Oct;102:89-119
pubmed: 30121124
PLoS One. 2013 Dec 20;8(12):e83059
pubmed: 24376633
BMC Nephrol. 2019 Nov 21;20(1):424
pubmed: 31752725
Immunol Cell Biol. 2013 Nov-Dec;91(10):625-33
pubmed: 24060963
Am J Pathol. 2014 Jul;184(7):2123-33
pubmed: 24819959
J Clin Invest. 2014 Jun;124(6):2333-40
pubmed: 24892707
Front Immunol. 2022 May 27;13:868127
pubmed: 35711407
Sci Immunol. 2019 May 10;4(35):
pubmed: 31076526
Nat Rev Nephrol. 2020 Apr;16(4):206-222
pubmed: 31942046
Biomed Res Int. 2023 Feb 2;2023:7629782
pubmed: 36778059
Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92
pubmed: 16876401
J Biol Chem. 2005 Jun 24;280(25):23936-44
pubmed: 15833747
J Immunol Res. 2017;2017:8193932
pubmed: 28706957
Kidney Int. 2018 Oct;94(4):741-755
pubmed: 29935951
Clin Chim Acta. 2006 Dec;374(1-2):33-45
pubmed: 16872589
Cell Death Dis. 2022 Mar 29;13(3):281
pubmed: 35351877
Am J Kidney Dis. 2014 Feb;63(2 Suppl 2):S39-62
pubmed: 24461729
J Biol Chem. 2005 Dec 2;280(48):39677-80
pubmed: 16204243
ACS Omega. 2020 Jan 30;5(5):2345-2354
pubmed: 32064396
Front Immunol. 2018 May 23;9:1002
pubmed: 29875766
Eur J Immunol. 2009 Feb;39(2):342-51
pubmed: 19130487
Curr Opin Mol Ther. 2006 Dec;8(6):529-38
pubmed: 17243489
Diabetes. 2009 Jul;58(7):1710-4
pubmed: 19366862
Lupus Sci Med. 2022 Dec;9(1):
pubmed: 36521939
Nephron. 2020;144(4):195-203
pubmed: 32050203
Bioengineered. 2021 Dec;12(1):5386-5401
pubmed: 34424825
Diabetes Res Clin Pract. 2022 Jan;183:109119
pubmed: 34879977
J Immunol. 2020 Nov 15;205(10):2834-2839
pubmed: 33028618
Nat Biotechnol. 2007 Nov;25(11):1256-64
pubmed: 17989688
Immunol Cell Biol. 2008 Feb;86(2):153-60
pubmed: 18227853
Nat Rev Nephrol. 2012 Feb 21;8(5):293-300
pubmed: 22349487
Trends Pharmacol Sci. 2022 Dec;43(12):1085-1097
pubmed: 36307250
Am J Physiol Renal Physiol. 2022 Jun 1;322(6):F597-F610
pubmed: 35379003
J Immunol. 2010 Dec 1;185(11):6741-52
pubmed: 20974988
PLoS One. 2015 Mar 24;10(3):e0119699
pubmed: 25803807
Front Immunol. 2022 Feb 25;13:811696
pubmed: 35281019
Ther Adv Hematol. 2019 Sep 10;10:2040620719874728
pubmed: 31534662
Sci Rep. 2017 Oct 25;7(1):14061
pubmed: 29070810
Science. 2005 Apr 15;308(5720):421-4
pubmed: 15761121
Curr Mol Med. 2012 Sep;12(8):1083-97
pubmed: 22812419
Adv Chronic Kidney Dis. 2020 Mar;27(2):86-94
pubmed: 32553250
Nat Rev Nephrol. 2017 May;13(5):311-318
pubmed: 28262777
Am J Respir Cell Mol Biol. 2016 Nov;55(5):657-666
pubmed: 27285858
Immunobiology. 2016 Jun;221(6):701-8
pubmed: 26307001
Clin Chim Acta. 2023 Feb 15;541:117238
pubmed: 36746263
PLoS One. 2011;6(6):e20984
pubmed: 21698200
Nephrol Dial Transplant. 2018 Aug 1;33(8):1323-1332
pubmed: 29294056
Nature. 2007 Mar 8;446(7132):203-7
pubmed: 17322907
Int J Mol Sci. 2021 Nov 01;22(21):
pubmed: 34769288
J Am Soc Nephrol. 2014 Oct;25(10):2342-50
pubmed: 24925722
J Clin Med. 2019 Jun 27;8(7):
pubmed: 31252541
Kidney Int Rep. 2018 Dec 03;4(3):434-446
pubmed: 30899871
Endocrine. 2012 Apr;41(2):296-301
pubmed: 22180093
J Immunol. 2003 Apr 1;170(7):3883-9
pubmed: 12646657
Fibrogenesis Tissue Repair. 2014 Nov 01;7:16
pubmed: 25383094
Kidney Int. 2001 Jul;60(1):137-46
pubmed: 11422745
Pathogens. 2015 Oct 23;4(4):722-38
pubmed: 26512700
Nat Med. 2019 May;25(5):805-813
pubmed: 31011203
Kidney Int. 2013 Sep;84(3):441-50
pubmed: 23615508
FASEB J. 2013 Mar;27(3):855-64
pubmed: 23239822
Sci Rep. 2018 May 25;8(1):8101
pubmed: 29802264
Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1619-25
pubmed: 16627811
Nat Rev Nephrol. 2014 Sep;10(9):493-503
pubmed: 24981817
Clin Chim Acta. 2018 Jul;482:65-73
pubmed: 29604259
Cell Signal. 2013 Apr;25(4):910-8
pubmed: 23268185
Rheumatology (Oxford). 2007 Dec;46(12):1773-8
pubmed: 17965442
J Diabetes Investig. 2022 May;13(5):839-849
pubmed: 34932275
J Immunol. 2013 Oct 15;191(8):4001-9
pubmed: 24043888
J Clin Endocrinol Metab. 2003 Oct;88(10):4857-61
pubmed: 14557465
J Am Soc Nephrol. 2016 Feb;27(2):405-16
pubmed: 26047789
J Am Soc Nephrol. 2008 Jun;19(6):1158-67
pubmed: 18354030
Clin Chim Acta. 2019 Sep;496:108-116
pubmed: 31276635
J Diabetes Res. 2016;2016:1825738
pubmed: 26977416
Front Med (Lausanne). 2017 May 30;4:66
pubmed: 28611987
Mol Biol Rep. 2013 Nov;40(11):6323-7
pubmed: 24078164
Blood. 2019 Feb 7;133(6):540-549
pubmed: 30510079
Diabetes. 2005 Oct;54(10):3002-6
pubmed: 16186405
Diabetes. 2006 Jun;55(6):1832-9
pubmed: 16731850
Nat Biotechnol. 2007 Nov;25(11):1265-75
pubmed: 17989689
Diabetes. 2020 Jan;69(1):83-98
pubmed: 31624141
Cell Signal. 2014 Jul;26(7):1409-19
pubmed: 24631530
J Immunol. 2015 Sep 15;195(6):2774-87
pubmed: 26283482
Kidney Int. 1994 Jul;46(1):89-96
pubmed: 7523758
Mol Immunol. 2019 Oct;114:123-132
pubmed: 31351413