Overview on Aneuploidy in Childhood B-Cell Acute Lymphoblastic Leukemia.
B-cell acute lymphoblastic leukemia
aneuploidy
chromosomal abnormalities
high hyperdiploidy
hypodiploidy
masked hypodiploid karyotype
prognosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 May 2023
15 May 2023
Historique:
received:
06
04
2023
revised:
04
05
2023
accepted:
10
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Recent years have brought significant progress in the treatment of B-cell acute lymphoblastic leukemia (ALL). This was influenced by both the improved schemes of conventionally used therapy, as well as the development of new forms of treatment. As a consequence, 5-year survival rates have increased and now exceed 90% in pediatric patients. For this reason, it would seem that everything has already been explored in the context of ALL. However, delving into its pathogenesis at the molecular level shows that there are many variations that still need to be analyzed in more detail. One of them is aneuploidy, which is among the most common genetic changes in B-cell ALL. It includes both hyperdiploidy and hypodiploidy. Knowledge of the genetic background is important already at the time of diagnosis, because the first of these forms of aneuploidy is characterized by a good prognosis, in contrast to the second, which is in favor of an unfavorable course. In our work, we will focus on summarizing the current state of knowledge on aneuploidy, along with an indication of all the consequences that may be correlated with it in the context of the treatment of patients with B-cell ALL.
Identifiants
pubmed: 37240110
pii: ijms24108764
doi: 10.3390/ijms24108764
pmc: PMC10218510
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Pediatr Blood Cancer. 2022 Oct;69(10):e29885
pubmed: 35856567
Exp Hematol Oncol. 2014 Jun 13;3:16
pubmed: 24949228
Cancer Genet Cytogenet. 2010 Feb;197(1):71-4
pubmed: 20113840
Nat Commun. 2023 Feb 13;14(1):809
pubmed: 36781850
Nat Genet. 2009 Sep;41(9):1001-5
pubmed: 19684603
Lancet Oncol. 2010 May;11(5):429-38
pubmed: 20409752
Blood. 1992 Jun 15;79(12):3245-52
pubmed: 1596566
Leukemia. 2022 Jul;36(7):1720-1748
pubmed: 35732829
Klin Wochenschr. 1967 Aug 1;45(15):763-8
pubmed: 5242235
Medicine (Baltimore). 2020 May 22;99(21):e20009
pubmed: 32481267
Br Med J. 1978 Dec 2;2(6151):1529-30
pubmed: 281981
Cancer Genet. 2016 Jul-Aug;209(7-8):340-7
pubmed: 27341996
Genes Chromosomes Cancer. 2021 Sep;60(9):604-615
pubmed: 33938069
Pediatr Blood Cancer. 2010 Sep;55(3):430-3
pubmed: 20658612
South Asian J Cancer. 2018 Oct-Dec;7(4):263-266
pubmed: 30430098
Leukemia. 2005 Mar;19(3):415-9
pubmed: 15674422
Mol Oncol. 2022 Aug;16(16):2899-2919
pubmed: 35726693
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21719-24
pubmed: 21098271
Nat Rev Mol Cell Biol. 2014 Mar;15(3):197-210
pubmed: 24556841
Br J Haematol. 2004 Jun;125(5):552-9
pubmed: 15147369
J Ayub Med Coll Abbottabad. 2022 Oct-Dec;34(Suppl 1)(4):S909-S912
pubmed: 36550642
Am J Hematol. 2008 Jan;83(1):34-40
pubmed: 17696201
Nat Rev Cancer. 2018 Aug;18(8):471-484
pubmed: 29784935
Leukemia. 2022 Jul;36(7):1703-1719
pubmed: 35732831
Lancet Oncol. 2008 Mar;9(3):257-68
pubmed: 18308251
Blood. 2007 Aug 15;110(4):1112-5
pubmed: 17473063
Nat Genet. 2018 Aug;50(8):1189-1195
pubmed: 30013179
Leuk Lymphoma. 1998 Nov;31(5-6):507-19
pubmed: 9922041
JAMA Oncol. 2022 Mar 01;8(3):354-363
pubmed: 35084434
Genes Chromosomes Cancer. 2007 Jul;46(7):684-93
pubmed: 17431878
Clin Lymphoma Myeloma Leuk. 2012 Aug;12(4):230-7
pubmed: 22609262
Pediatr Blood Cancer. 2015 Oct;62(10):1700-8
pubmed: 25982135
J Natl Cancer Inst. 2004 Oct 20;96(20):1549-56
pubmed: 15494605
Genes Chromosomes Cancer. 2019 Oct;58(10):723-730
pubmed: 31102422
Leukemia. 2008 Sep;22(9):1692-7
pubmed: 18548099
Blood Cells Mol Dis. 2020 Nov;85:102465
pubmed: 32693366
Blood. 1999 Dec 15;94(12):4036-45
pubmed: 10590047
Nat Rev Genet. 2020 Jan;21(1):44-62
pubmed: 31548659
Leukemia. 2021 May;35(5):1475-1479
pubmed: 33580201
Virchows Arch. 2023 Jan;482(1):11-26
pubmed: 36422706
J Clin Oncol. 2019 Apr 1;37(10):780-789
pubmed: 30742559
Pediatr Hematol Oncol. 2022 Nov;39(8):747-754
pubmed: 35275800
Haematologica. 2013 Sep;98(9):1424-32
pubmed: 23645689
Br J Haematol. 2011 Jul;154(2):275-7
pubmed: 21518330
J Coll Physicians Surg Pak. 2022 Nov;32(11):1430-1434
pubmed: 36377010
Genes Chromosomes Cancer. 2009 Aug;48(8):637-60
pubmed: 19415723
Indian J Hematol Blood Transfus. 2019 Oct;35(4):640-648
pubmed: 31741615
Blood. 1993 May 1;81(9):2237-51
pubmed: 8481506
Best Pract Res Clin Haematol. 2020 Sep;33(3):101193
pubmed: 33038982
Hemasphere. 2018 Jun 20;2(4):e53
pubmed: 31723781
Cancer Genet. 2019 Oct;238:62-68
pubmed: 31425927
Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1230-5
pubmed: 15247135
Blood. 2010 Jan 14;115(2):206-14
pubmed: 19897583
Leukemia. 2022 Jul;36(7):1701-1702
pubmed: 35732830
Lancet. 2005 Aug 20-26;366(9486):635-42
pubmed: 16112299
Br J Haematol. 2019 May;185(3):613-616
pubmed: 30255927
Blood Cancer Discov. 2021 Jul;2(4):326-337
pubmed: 34250504
Br J Haematol. 2019 Jul;186(2):263-268
pubmed: 30916384
Int J Cancer. 2020 Jun 15;146(12):3516-3521
pubmed: 32170735
Br J Haematol. 2001 Apr;113(1):103-14
pubmed: 11328289
J Mol Diagn. 2022 Nov;24(11):1195-1206
pubmed: 35963521
Eur J Haematol. 2000 Mar;64(3):194-200
pubmed: 10997886
Br J Haematol. 2005 May;129(4):520-30
pubmed: 15877734
Blood. 2003 Oct 15;102(8):2756-62
pubmed: 12829593
Int J Mol Sci. 2022 Mar 02;23(5):
pubmed: 35269896
Lancet Haematol. 2021 Nov;8(11):e828-e839
pubmed: 34715050
Cancer Genet Cytogenet. 1985 Oct;18(2):113-21
pubmed: 3863695
Genes Chromosomes Cancer. 2012 Jun;51(6):536-44
pubmed: 22334476
Leuk Lymphoma. 2003 Dec;44(12):2039-53
pubmed: 14959846
Clin Med Insights Oncol. 2017 Jul 24;11:1179554917721710
pubmed: 28811744
Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11711-E11720
pubmed: 30487223
Mol Cell Oncol. 2015 Jul 06;3(1):e1064555
pubmed: 27308574
Blood. 2015 Dec 24;126(26):2896-9
pubmed: 26527677
Br J Haematol. 1997 Oct;99(1):93-100
pubmed: 9359508
Blood. 2004 Oct 15;104(8):2444-51
pubmed: 15039281
Haematologica. 2016 Apr;101(4):407-16
pubmed: 27033238
Curr Med Sci. 2022 Feb;42(1):201-209
pubmed: 34874488
Int J Cancer. 2018 Dec 1;143(11):2647-2658
pubmed: 29923177
Nat Genet. 2013 Mar;45(3):242-52
pubmed: 23334668
Nat Genet. 2015 Jun;47(6):672-6
pubmed: 25961940
Blood Rev. 2004 Jun;18(2):115-36
pubmed: 15010150
Blood Adv. 2020 Oct 27;4(20):5165-5173
pubmed: 33095873
Biol Blood Marrow Transplant. 2015 Jul;21(7):1273-7
pubmed: 25865650
Blood. 2013 Mar 28;121(13):2415-23
pubmed: 23321258
Eur J Cancer. 2022 Nov;175:120-124
pubmed: 36113241
J Clin Oncol. 2000 May;18(9):1876-87
pubmed: 10784628
Blood. 2020 Jan 16;135(3):159-166
pubmed: 31738819
Leukemia. 2022 Dec;36(12):2769-2783
pubmed: 36266323
Am J Epidemiol. 2003 Oct 15;158(8):724-35
pubmed: 14561661
Cancer Genet Cytogenet. 2006 Aug;169(1):50-7
pubmed: 16875937
Blood. 2021 Sep 16;138(11):915-916
pubmed: 34529020
Leukemia. 2016 May;30(5):1194-7
pubmed: 26437776
Oncotarget. 2015 Dec 15;6(40):42793-802
pubmed: 26544893
Cancer. 1968 Dec;22(6):1268-82
pubmed: 5249420
J Clin Invest. 2012 Oct;122(10):3407-15
pubmed: 23023711
Cancer. 2003 Dec 15;98(12):2715-22
pubmed: 14669294
Leukemia. 2013 Jan;27(1):248-50
pubmed: 22889820
Nat Genet. 2009 Sep;41(9):1006-10
pubmed: 19684604
J Natl Cancer Inst. 2020 Jul 1;112(7):756-764
pubmed: 31647544
Cancer Genet Cytogenet. 1992 Nov;64(1):49-55
pubmed: 1458450
Cancers (Basel). 2021 Dec 22;14(1):
pubmed: 35008193
Nat Rev Mol Cell Biol. 2022 Apr;23(4):250-265
pubmed: 34987171
Clin Lab Haematol. 2004 Feb;26(1):25-30
pubmed: 14738434
Blood. 1987 Jul;70(1):247-53
pubmed: 3474042
Blood. 1990 Mar 1;75(5):1170-7
pubmed: 2306521
Cancer Metastasis Rev. 2020 Mar;39(1):161-171
pubmed: 31902036
Cold Spring Harb Perspect Med. 2017 Mar 1;7(3):
pubmed: 28003275
Genes Chromosomes Cancer. 1992 Jun;4(4):331-6
pubmed: 1377941
Genes Chromosomes Cancer. 2014 Jun;53(6):524-36
pubmed: 24619868
J Clin Oncol. 2019 Apr 1;37(10):770-779
pubmed: 30657737
Blood. 2014 Jul 10;124(2):251-8
pubmed: 24829203
Cent Eur J Immunol. 2021;46(3):365-374
pubmed: 34764809
Blood. 2017 Jan 26;129(4):420-423
pubmed: 27903530
Br J Haematol. 2019 Apr;185(2):266-283
pubmed: 30714092
Blood. 1996 Apr 15;87(8):3135-42
pubmed: 8605327
Leukemia. 2005 May;19(5):734-40
pubmed: 15789069
Blood. 2007 Apr 15;109(8):3189-97
pubmed: 17170120
Cancer Genet Cytogenet. 2001 Jul 15;128(2):108-13
pubmed: 11463448
Nat Commun. 2019 Apr 3;10(1):1519
pubmed: 30944321
Blood. 2008 Feb 1;111(3):1575-83
pubmed: 17971484
J Clin Med. 2022 Oct 26;11(21):
pubmed: 36362526
Trends Cancer. 2016 Oct;2(10):561-571
pubmed: 28741487
Eur J Haematol. 2010 Oct;85(4):300-8
pubmed: 20561032
Genes Chromosomes Cancer. 2008 Jan;47(1):26-33
pubmed: 17910045
Blood. 1990 Aug 1;76(3):590-6
pubmed: 2378987
Nat Commun. 2016 Feb 15;7:10754
pubmed: 26876972
Br J Haematol. 1989 Jul;72(3):336-42
pubmed: 2765402
Chromosoma. 2005 Sep;114(4):286-94
pubmed: 16003502
Am J Hematol. 2022 May;97(5):514-518
pubmed: 35179244
Cancer Res Treat. 2021 Apr;53(2):567-575
pubmed: 33070555
Cancer Genet Cytogenet. 2004 Jan 15;148(2):159-62
pubmed: 14734231
Indian J Med Paediatr Oncol. 2012 Jul;33(3):166-9
pubmed: 23248423
Pediatr Int. 2019 Nov;61(11):1103-1108
pubmed: 31519067