Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System.
Cav1
Cav2
Cav3
G protein
GPCR
L-type calcium channel
N-type calcium channel
P/Q-type calcium channel
R-type calcium channel
T-type calcium channel
calcium
calcium channel blockers
calcium homeostasis
calcium overload
calcium pumps
endoplasmic reticulum
hypercalcemia
mitochondria
nucleus
sodium/calcium exchanger
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 May 2023
15 May 2023
Historique:
received:
21
02
2023
revised:
06
05
2023
accepted:
10
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Calcium is a highly positively charged ionic species. It regulates all cell types' functions and is an important second messenger that controls and triggers several mechanisms, including membrane stabilization, permeability, contraction, secretion, mitosis, intercellular communications, and in the activation of kinases and gene expression. Therefore, controlling calcium transport and its intracellular homeostasis in physiology leads to the healthy functioning of the biological system. However, abnormal extracellular and intracellular calcium homeostasis leads to cardiovascular, skeletal, immune, secretory diseases, and cancer. Therefore, the pharmacological control of calcium influx directly via calcium channels and exchangers and its outflow via calcium pumps and uptake by the ER/SR are crucial in treating calcium transport remodeling in pathology. Here, we mainly focused on selective calcium transporters and blockers in the cardiovascular system.
Identifiants
pubmed: 37240147
pii: ijms24108803
doi: 10.3390/ijms24108803
pmc: PMC10218565
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
Calcium Channels
0
Calcium Channel Blockers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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