New Approaches in Heart Research: Prevention Instead of Cardiomyoplasty?
cardiovascular disease
heart failure
obesity
physical exercise
prevention
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
04
04
2023
revised:
10
05
2023
accepted:
17
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Cardiovascular diseases are the leading cause of death in industrialized nations. Due to the high number of patients and expensive treatments, according to the Federal Statistical Office (2017) in Germany, cardiovascular diseases account for around 15% of total health costs. Advanced coronary artery disease is mainly the result of chronic disorders such as high blood pressure, diabetes, and dyslipidemia. In the modern obesogenic environment, many people are at greater risk of being overweight or obese. The hemodynamic load on the heart is influenced by extreme obesity, which often leads to myocardial infarction (MI), cardiac arrhythmias, and heart failure. In addition, obesity leads to a chronic inflammatory state and negatively affects the wound-healing process. It has been known for many years that lifestyle interventions such as exercise, healthy nutrition, and smoking cessation drastically reduce cardiovascular risk and have a preventive effect against disorders in the healing process. However, little is known about the underlying mechanisms, and there is significantly less high-quality evidence compared to pharmacological intervention studies. Due to the immense potential of prevention in heart research, the cardiologic societies are calling for research work to be intensified, from basic understanding to clinical application. The topicality and high relevance of this research area are also evident from the fact that in March 2018, a one-week conference on this topic with contributions from top international scientists took place as part of the renowned "Keystone Symposia" ("New Insights into the Biology of Exercise"). Consistent with the link between obesity, exercise, and cardiovascular disease, this review attempts to draw lessons from stem-cell transplantation and preventive exercise. The application of state-of-the-art techniques for transcriptome analysis has opened new avenues for tailoring targeted interventions to very individual risk factors.
Identifiants
pubmed: 37240361
pii: ijms24109017
doi: 10.3390/ijms24109017
pmc: PMC10219243
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : German Heart Research Foundation
ID : F/34/15
Organisme : Deutsche Forschungsgemeinschaft
ID : VA1797/1-1
Organisme : EU Structural Fund
ID : ESF/14-BMA55-0024/18
Organisme : Deutsche Forschungsgemeinschaft
ID : DA1296/6-1
Organisme : Deutsche Herzstiftung
ID : F/01/12
Organisme : Federal Ministry of Education and Research
ID : VIP + 00240
Organisme : Josef & Käthe Klinz Stiftung
ID : T319/29737/2017
Organisme : Coordination for the Improvement of Higher Education Personnel - Brazil
ID : 001
Références
Sci Transl Med. 2014 Dec 3;6(265):265sr6
pubmed: 25473038
Acta Cir Bras. 2010 Feb;25(1):86-92
pubmed: 20126894
Magn Reson Med. 2003 Mar;49(3):417-23
pubmed: 12594743
J Mol Cell Cardiol. 1998 Aug;30(8):1559-69
pubmed: 9737942
Immunol Cell Biol. 2019 Mar;97(3):258-267
pubmed: 30746824
J Clin Invest. 2002 Jan;109(1):121-30
pubmed: 11781357
J Am Coll Cardiol. 2005 Mar 15;45(6):931-8
pubmed: 15766831
Antioxid Redox Signal. 2006 Nov-Dec;8(11-12):1907-39
pubmed: 17034340
Circulation. 1995 Aug 1;92(3):657-71
pubmed: 7634481
Eur J Nucl Med Mol Imaging. 2014 Dec;41(12):2325-36
pubmed: 25063040
Circ Res. 2011 Jun 10;108(12):1448-58
pubmed: 21527738
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10733-8
pubmed: 11535818
Cell Mol Life Sci. 2021 Oct;78(19-20):6585-6592
pubmed: 34427691
Adv Wound Care (New Rochelle). 2014 Jan 1;3(1):71-79
pubmed: 24761347
Br J Nutr. 2006 Dec;96(6):1069-77
pubmed: 17181882
J Clin Invest. 2003 Feb;111(3):419-26
pubmed: 12569168
J Am Heart Assoc. 2018 Feb 8;7(4):
pubmed: 29437600
J Clin Invest. 2011 Mar;121(3):985-97
pubmed: 21317534
Circulation. 2001 Jul 17;104(3):365-72
pubmed: 11457759
Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2504-14
pubmed: 16731644
Endocrinology. 2003 Dec;144(12):5159-65
pubmed: 12960011
J Exp Med. 2007 Nov 26;204(12):3037-47
pubmed: 18025128
Eur Heart J. 2016 Jun 14;37(23):1789-98
pubmed: 27055812
Circ Res. 2018 Jul 6;123(2):132-137
pubmed: 29976683
Lancet. 2005 Nov 12;366(9498):1736-43
pubmed: 16291068
Circ Res. 2005 Feb 4;96(2):225-33
pubmed: 15618539
Int J Cardiol. 2006 Jun 16;110(2):153-9
pubmed: 16043245
Prog Cardiovasc Dis. 2015 Mar-Apr;57(5):443-53
pubmed: 25446554
Cells. 2020 May 06;9(5):
pubmed: 32384695
Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R179-84
pubmed: 18003791
Heart. 2010 Dec;96(23):1883-4
pubmed: 20962339
J Clin Immunol. 2008 Jul;28(4):314-21
pubmed: 18224429
Cells. 2020 Aug 03;9(8):
pubmed: 32756334
JAMA. 2004 Jun 16;291(23):2847-50
pubmed: 15199035
Coron Artery Dis. 2011 Nov;22(7):497-506
pubmed: 21785345
Eur J Nucl Med Mol Imaging. 2013 Oct;40(11):1730-8
pubmed: 23860738
EBioMedicine. 2017 Aug;22:208-224
pubmed: 28781130
Obes Surg. 2011 Dec;21(12):1937-46
pubmed: 21347822
Cells. 2019 Dec 27;9(1):
pubmed: 31892273
Stem Cells. 2004;22(5):812-22
pubmed: 15342945
Circulation. 2010 Sep 28;122(13):1258-64
pubmed: 20837897
Am J Pathol. 1995 Aug;147(2):325-38
pubmed: 7639329
Cells. 2019 Nov 20;8(12):
pubmed: 31757119
Cell Physiol Biochem. 2017;42(1):254-268
pubmed: 28535507
Am J Physiol Heart Circ Physiol. 2015 Jul 15;309(2):H345-59
pubmed: 26001415
Wound Repair Regen. 2016 Jul;24(4):613-29
pubmed: 27196106
Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1480-8
pubmed: 25814674
Curr Opin Pharmacol. 2013 Apr;13(2):210-7
pubmed: 23357129
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1784-9
pubmed: 10677535
Nat Rev Immunol. 2011 Oct 14;11(11):723-37
pubmed: 21997792
Diabetes. 2012 Nov;61(11):2937-47
pubmed: 22688339
J Clin Invest. 2000 Jul;106(2):171-6
pubmed: 10903330
J Am Coll Cardiol. 2000 Jan;35(1):144-50
pubmed: 10636272
Am J Pathol. 2007 Apr;170(4):1178-91
pubmed: 17392158
Mech Ageing Dev. 2014 Jul;139:41-8
pubmed: 24932991
J Clin Invest. 2014 Mar;124(3):1382-92
pubmed: 24569380
Cells. 2020 Jan 28;9(2):
pubmed: 32013057
Circulation. 1994 Jan;89(1):36-44
pubmed: 8281670
PLoS One. 2014 Mar 11;9(3):e91574
pubmed: 24618995
FASEB J. 2004 Nov;18(14):1692-700
pubmed: 15522914
Eur J Prev Cardiol. 2019 Mar;26(5):522-530
pubmed: 29911893
NPJ Regen Med. 2018 Nov 7;3:21
pubmed: 30416753
J Gastroenterol Hepatol. 2001 Jun;16(6):599-606
pubmed: 11422610
Int J Cardiol. 2006 Mar 8;107(3):395-9
pubmed: 16503262
Cardiovasc Res. 2020 Jun 1;116(7):1249-1251
pubmed: 32243511
Ann Clin Lab Sci. 2005 Winter;35(1):73-8
pubmed: 15830712
Basic Res Cardiol. 2002 Sep;97(5):343-7
pubmed: 12200633
Cells. 2020 May 30;9(6):
pubmed: 32486211
Exerc Immunol Rev. 2011;17:6-63
pubmed: 21446352
J Clin Invest. 2001 Apr;107(7):813-22
pubmed: 11285300
Cardiovasc Res. 1993 Nov;27(11):1954-60
pubmed: 8287403
Eur Heart J. 2020 Jan 14;41(3):407-477
pubmed: 31504439
N Engl J Med. 1997 May 1;336(18):1276-82
pubmed: 9113930
JAMA. 1998 Dec 16;280(23):2001-7
pubmed: 9863851
Cytokine. 2011 Nov;56(2):256-64
pubmed: 21803601
Ann Vasc Surg. 1999 Jan;13(1):77-83
pubmed: 9878661
Eur J Prev Cardiol. 2020 Jan;27(2):181-205
pubmed: 31826679
Hum Nat. 1991 Mar;2(1):31-57
pubmed: 24222189
N Engl J Med. 2002 Aug 1;347(5):305-13
pubmed: 12151467
Obes Rev. 2008 Mar;9(2):165-80
pubmed: 18257754
Sci Rep. 2017 Aug 29;7(1):9755
pubmed: 28852100
Nature. 1997 Apr 17;386(6626):671-4
pubmed: 9109485
Circ Res. 2002 Feb 22;90(3):251-62
pubmed: 11861412
Nature. 2002 Nov 21;420(6913):333-6
pubmed: 12447443
Eur Heart J. 2019 Apr 14;40(15):1213
pubmed: 30137339
Mol Imaging Biol. 2015 Dec;17(6):874-83
pubmed: 25896817
J Nutr. 2005 Aug;135(8):1841-6
pubmed: 16046706
Immunity. 2006 May;24(5):611-22
pubmed: 16713978
Eur J Prev Cardiol. 2020 Nov;27(16):1756-1774
pubmed: 32089005
Cell. 2005 Jan 28;120(2):169-81
pubmed: 15680324
Protein Sci. 2017 Apr;26(4):662-676
pubmed: 28160335
BMJ. 2017 Nov 14;359:j4849
pubmed: 29138133
Eur J Prev Cardiol. 2020 Jan;27(2):177-180
pubmed: 31916864
Int J Cardiol. 2007 Jul 31;119(3):283-90
pubmed: 17166606
Cells. 2019 Dec 11;8(12):
pubmed: 31835854
Circulation. 2004 Nov 2;110(18):2952-67
pubmed: 15509809
Exp Diabetes Res. 2010;2010:476969
pubmed: 21318183
Biomedicines. 2020 Jun 11;8(6):
pubmed: 32545336
J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1432-6
pubmed: 16339330
EBioMedicine. 2020 Jul;57:102862
pubmed: 32629392
Nat Rev Immunol. 2011 Aug 05;11(9):607-15
pubmed: 21818123
Diabetes. 2015 Apr;64(4):1420-30
pubmed: 25368099