Eosinophil Granule Proteins Involvement in Acute Appendicitis-An Allergic Disease?
Eosinophil-derived neurotoxin
allergy
appendicitis
eosinophil cation protein
eosinophil peroxidase
eosinophils
hypersensitivity type 1 reaction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 May 2023
22 May 2023
Historique:
received:
15
04
2023
revised:
11
05
2023
accepted:
13
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Several pieces of evidence point to an allergic component as a trigger of acute appendicitis. As the Th2 immune response is characterized by eosinophil mobilization to the target organ and release of their cationic granule proteins, it is reasonable to investigate if the degranulation of eosinophils could be associated with the local injury. The primary aim of this study is to evaluate the participation of eosinophils granules proteins in acute appendicitis, both at local and systemic levels and the secondary aim is to evaluate the diagnostic accuracy of eosinophils granules proteins for the detection of acute appendicitis, as well as for distinguishing between complicated and uncomplicated acute appendicitis. Eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP) and eosinophil peroxidase (EP) are the most well-known eosinophil granule proteins. From August 2021 to April 2022, we present a prospective single-center study to evaluate the EDN, ECP, and EP concentrations simultaneously in appendicular lavage fluid (ALF) and the serum of 22 patients with acute phlegmonous appendicitis (APA), 24 with acute gangrenous appendicitis (AGA), and 14 normal controls. Concerning EDN, no differences were found between groups. ECP concentrations in ALF and serum were significantly higher in the histologically confirmed acute appendicitis compared to the control groups (
Identifiants
pubmed: 37240441
pii: ijms24109091
doi: 10.3390/ijms24109091
pmc: PMC10219475
pii:
doi:
Substances chimiques
Eosinophil Granule Proteins
0
Blood Proteins
0
Ribonucleases
EC 3.1.-
Eosinophil-Derived Neurotoxin
EC 3.1.-
Eosinophil Cationic Protein
EC 3.1.27.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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