Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke.

biomarkers cerebrovascular disease circRNAs ischemia noncoding RNAs stroke

Journal

Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269

Informations de publication

Date de publication:
16 May 2023
Historique:
received: 17 04 2023
revised: 12 05 2023
accepted: 14 05 2023
medline: 27 5 2023
pubmed: 27 5 2023
entrez: 27 5 2023
Statut: epublish

Résumé

Despite the substantial improvement in diagnosis and treatment within the last decades, ischemic stroke still represents a challenge, responsible still for a high burden of morbidity and mortality. Among the unmet clinical needs are the difficulties in identifying those subjects with the greatest risk of developing a stroke, the challenges in obtaining a timely diagnosis, the prompt recognition of the different clinical forms of stroke, the assessment of the response to treatments and the prognostic assessment. All these issues might be improved with appropriate smart biomarkers that could better inform clinical management. The present article offers an overview of the potential role of circular RNAs as disease biomarkers in stroke. A systematic approach was adopted to gather all potentially relevant information in order to provide a panoramic view on this class of promising molecules.

Identifiants

pubmed: 37241009
pii: jpm13050839
doi: 10.3390/jpm13050839
pmc: PMC10221059
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : National Science Center
ID : 2018/31/B/NZ7/01137

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Auteurs

Chiara Siracusa (C)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Niccolò Vono (N)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Maria Benedetta Morano (MB)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Jolanda Sabatino (J)

Department of Children and Woman's Health, University of Padua, 35121 Padua, Italy.

Isabella Leo (I)

Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London SW3 5NP, UK.
Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Ceren Eyileten (C)

Centre for Preclinical Research and Technology, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 02-097 Warsaw, Poland.
Genomics Core Facility, Center of New Technologies, University of Warsaw, 00-927 Warsaw, Poland.

Eleonora Cianflone (E)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Marek Postula (M)

Centre for Preclinical Research and Technology, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 02-097 Warsaw, Poland.

Daniele Torella (D)

Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Salvatore De Rosa (S)

Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Classifications MeSH