Targeted Drug Administration onto Cancer Cells Using Hyaluronic Acid-Quercetin-Conjugated Silver Nanoparticles.
cytotoxicity
functional polymer–drug conjugates
hemocompatibility
nanodrug delivery systems
oncotargets
silver nanoparticles
water-soluble quercetin
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
17 May 2023
17 May 2023
Historique:
received:
02
03
2023
revised:
17
04
2023
accepted:
11
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Quercetin (QtN) displays low systemic bioavailability caused by poor water solubility and instability. Consequently, it exerts limited anticancer action in vivo. One solution to increase the anticancer efficacy of QtN is the use of appropriate functionalized nanocarriers that preferentially target and deliver the drug to the tumor location. Herein, a direct advanced method was designed to develop water-soluble hyaluronic acid (HA)-QtN-conjugated silver nanoparticles (AgNPs). HA-QtN reduced silver nitrate (AgNO
Identifiants
pubmed: 37241888
pii: molecules28104146
doi: 10.3390/molecules28104146
pmc: PMC10221215
pii:
doi:
Substances chimiques
Hyaluronic Acid
9004-61-9
Quercetin
9IKM0I5T1E
Silver
3M4G523W1G
Polyethylene Glycols
3WJQ0SDW1A
Water
059QF0KO0R
Biological Products
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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