Divergent Hantavirus in Somali Shrews (

Crocidura somalica Kenya hantavirus phylogenetics shrews

Journal

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317

Informations de publication

Date de publication:
07 May 2023
Historique:
received: 10 02 2023
revised: 21 04 2023
accepted: 04 05 2023
medline: 27 5 2023
pubmed: 27 5 2023
entrez: 27 5 2023
Statut: epublish

Résumé

Hantaviruses are zoonotic rodent-borne viruses that are known to infect humans and cause various symptoms of disease, including hemorrhagic fever with renal and cardiopulmonary syndromes. They have a segmented single-stranded, enveloped, negative-sense RNA genome and are widely distributed. This study aimed to investigate the circulation of rodent-borne hantaviruses in peridomestic rodents and shrews in two semi-arid ecologies within the Kenyan Rift Valley. The small mammals were trapped using baited folding Sherman traps set within and around houses, then they were sedated and euthanatized through cervical dislocation before collecting blood and tissue samples (liver, kidney, spleen, and lungs). Tissue samples were screened with pan-hantavirus PCR primers, targeting the large genome segment (L) encoding the RNA-dependent RNA polymerase (RdRp). Eleven of the small mammals captured were shrews (11/489, 2.5%) and 478 (97.5%) were rodents. A cytochrome b gene-based genetic assay for shrew identification confirmed the eleven shrews sampled to be

Identifiants

pubmed: 37242355
pii: pathogens12050685
doi: 10.3390/pathogens12050685
pmc: PMC10221196
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : JU 2857/9-1 and JU 2857/9-2

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Auteurs

Dorcus C A Omoga (DCA)

International Centre of Insect Physiology and Ecology, Nairobi P.O. Box 30772-00100, Kenya.
Zoonotic arbo and Respiratory Virus Research Program, Centre for Viral Zoonoses, Department of Medical Virology, Faculty of Health, University of Pretoria, Gezina 0031, South Africa.

David P Tchouassi (DP)

International Centre of Insect Physiology and Ecology, Nairobi P.O. Box 30772-00100, Kenya.

Marietjie Venter (M)

Zoonotic arbo and Respiratory Virus Research Program, Centre for Viral Zoonoses, Department of Medical Virology, Faculty of Health, University of Pretoria, Gezina 0031, South Africa.

Edwin O Ogola (EO)

International Centre of Insect Physiology and Ecology, Nairobi P.O. Box 30772-00100, Kenya.

Gilbert Rotich (G)

International Centre of Insect Physiology and Ecology, Nairobi P.O. Box 30772-00100, Kenya.

Joseph N Muthoni (JN)

International Centre of Insect Physiology and Ecology, Nairobi P.O. Box 30772-00100, Kenya.

Dickens O Ondifu (DO)

International Centre of Insect Physiology and Ecology, Nairobi P.O. Box 30772-00100, Kenya.

Baldwyn Torto (B)

International Centre of Insect Physiology and Ecology, Nairobi P.O. Box 30772-00100, Kenya.

Sandra Junglen (S)

Institute of Virology, Charité Universitätsmedizin Berlin, Corporate Member of Free University Berlin, Humboldt-University Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Rosemary Sang (R)

International Centre of Insect Physiology and Ecology, Nairobi P.O. Box 30772-00100, Kenya.

Classifications MeSH