Polyglactin 910 Meshes Coated with Sustained-Release Cannabigerol Varnish Inhibit

Staphylococcus aureus biofilm cannabigerol cytokines macrophages mesh sustained-release varnish

Journal

Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453

Informations de publication

Date de publication:
13 May 2023
Historique:
received: 03 04 2023
revised: 02 05 2023
accepted: 11 05 2023
medline: 27 5 2023
pubmed: 27 5 2023
entrez: 27 5 2023
Statut: epublish

Résumé

Synthetic surgical meshes are commonly used in abdominal wall reconstruction surgeries to strengthen a weak abdominal wall. Common mesh-related complications include local infection and inflammatory processes. Because cannabigerol (CBG) has both antibacterial and anti-inflammatory properties, we proposed that coating VICRYL (polyglactin 910) mesh with a sustained-release varnish (SRV) containing CBG would prevent these complications. We used an in vitro infection model with

Identifiants

pubmed: 37242528
pii: ph16050745
doi: 10.3390/ph16050745
pmc: PMC10221007
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : STEP-GTP
ID : 0

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Auteurs

Mustafa Abudalu (M)

The Biofilm Research Laboratory, The Institute of Biomedical and Oral Research (IBOR), The Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Department of General Surgery, Barzilai Medical Center, Ashkelon 7830604, Israel.

Muna Aqawi (M)

The Biofilm Research Laboratory, The Institute of Biomedical and Oral Research (IBOR), The Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
The Institute of Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Ronit Vogt Sionov (RV)

The Biofilm Research Laboratory, The Institute of Biomedical and Oral Research (IBOR), The Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Michael Friedman (M)

The Institute of Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Irith Gati (I)

The Institute of Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Yaron Munz (Y)

Department of General Surgery, Barzilai Medical Center, Ashkelon 7830604, Israel.

Gil Ohana (G)

Department of General Surgery, Barzilai Medical Center, Ashkelon 7830604, Israel.

Doron Steinberg (D)

The Biofilm Research Laboratory, The Institute of Biomedical and Oral Research (IBOR), The Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Classifications MeSH