Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping.
Raman imaging
amorphous phase separation
confocal Raman spectroscopy
copovidone
kinetics
miscibility gap
phase behavior
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
02 May 2023
02 May 2023
Historique:
received:
27
03
2023
revised:
27
04
2023
accepted:
28
04
2023
medline:
27
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
The poor bioavailability of an active pharmaceutical ingredient (API) can be enhanced by dissolving it in a polymeric matrix. This formulation strategy is commonly known as amorphous solid dispersion (ASD). API crystallization and/or amorphous phase separation can be detrimental to the bioavailability. Our previous work (
Identifiants
pubmed: 37242637
pii: pharmaceutics15051395
doi: 10.3390/pharmaceutics15051395
pmc: PMC10223424
pii:
doi:
Types de publication
Journal Article
Langues
eng
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