The Role of Antiviral Prophylaxis in Preventing HBV and HDV Recurrence in the Setting of Liver Transplantation.
Humans
Hepatitis B virus
Liver Transplantation
/ adverse effects
Hepatitis Delta Virus
Hepatitis B
/ drug therapy
Carcinoma, Hepatocellular
Antiviral Agents
/ therapeutic use
Hepatitis B Surface Antigens
Liver Neoplasms
Immunoglobulins
/ therapeutic use
Treatment Outcome
Neoplasm Recurrence, Local
Hepatitis B Antibodies
HBV
HBV prophylaxis
HDV
liver transplantation
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
23 04 2023
23 04 2023
Historique:
received:
30
03
2023
revised:
15
04
2023
accepted:
21
04
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Hepatitis B virus (HBV) is a prevalent underlying disease, leading to liver transplantation (LT) for both decompensated cirrhosis and hepatocellular carcinoma (HCC). The hepatitis delta virus (HDV) affects approximately 5-10% of HBsAg carriers, accelerating the progression of liver injury and HCC. The initial introduction of HBV immunoglobulins (HBIG), and then of nucleos(t)ide analogues (NUCs), considerably improved the survival of HBV/HDV patients post-transplantation, as they helped prevent re-infection of the graft and recurrence of liver disease. Combination therapy with HBIG and NUCs is the primary post-transplant prophylaxis strategy in patients transplanted for HBV- and HDV-related liver disease. However, monotherapy with high-barrier NUCs, such as entecavir and tenofovir, is safe and also effective in some individuals who are at low risk of HBV reactivation. To address the problems of organ shortage, last-generation NUCs have facilitated the use of anti-HBc and HBsAg-positive grafts to meet the ever-increasing demand for grafts.
Identifiants
pubmed: 37243124
pii: v15051037
doi: 10.3390/v15051037
pmc: PMC10224456
pii:
doi:
Substances chimiques
Antiviral Agents
0
Hepatitis B Surface Antigens
0
Immunoglobulins
0
Hepatitis B Antibodies
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Dig Liver Dis. 2018 Sep;50(9):944-953
pubmed: 29735294
Hepatology. 2002 Jun;35(6):1528-35
pubmed: 12029640
J Hepatol. 2019 Jun;70(6):1114-1122
pubmed: 30871981
Transpl Infect Dis. 2017 Feb;19(1):
pubmed: 27886432
Liver Transpl. 2016 Feb;22(2):247-51
pubmed: 26600319
Aliment Pharmacol Ther. 2021 Sep;54(5):583-605
pubmed: 34287994
Liver Transpl. 2013 Jun;19(6):594-601
pubmed: 23447407
J Hepatol. 2022 Feb;76(2):464-469
pubmed: 34699951
Liver Transpl. 2023 Jan 1;29(1):80-90
pubmed: 35844046
Liver Transpl. 2013 Aug;19(8):887-95
pubmed: 23788462
Hepatology. 1998 Aug;28(2):585-9
pubmed: 9696028
Hepatology. 2014 Dec;60(6):2099-108
pubmed: 25164003
Lancet. 1991 Apr 6;337(8745):813-5
pubmed: 1672913
Transplant Proc. 2010 Oct;42(8):3167-8
pubmed: 20970638
Hepatology. 1996 Dec;24(6):1327-33
pubmed: 8938155
J Hepatol. 2022 Dec;77(6):1525-1531
pubmed: 35973578
J Hepatol. 2013 Feb;58(2):287-96
pubmed: 23099188
Gut. 2019 Mar;68(3):512-521
pubmed: 30228220
Liver Transpl. 2011 Oct;17(10):1176-90
pubmed: 21656655
Hepatology. 2017 Oct;66(4):1036-1044
pubmed: 28370215
J Hepatol. 2010 Feb;52(2):272-9
pubmed: 20034693
J Hepatol. 2003;39 Suppl 1:S212-9
pubmed: 14708706
Transplantation. 1996 May 15;61(9):1358-64
pubmed: 8629297
Hepatol Int. 2020 Jan;14(1):57-69
pubmed: 31919678
Transplantation. 2017 Sep;101(9):2079-2082
pubmed: 28880197
J Infect Dis. 2019 Apr 19;219(10):1624-1633
pubmed: 30689910
Int J Clin Exp Pathol. 2014 Jun 15;7(7):4057-66
pubmed: 25120784
Gastroenterology. 2011 Oct;141(4):1212-9
pubmed: 21762659
Hepatol Res. 2013 Jan;43(1):67-71
pubmed: 22548744
Transpl Infect Dis. 2012 Oct;14(5):479-87
pubmed: 22624695
Liver Transpl. 2013 Sep;19(9):1020-9
pubmed: 23852663
Transpl Infect Dis. 2015 Oct;17(5):695-701
pubmed: 26257166
J Hepatol. 1992 Jan;14(1):104-11
pubmed: 1737910
Hepatology. 2018 Aug;68(2):425-434
pubmed: 29108132
Am J Transplant. 2015 Feb;15(2):535-40
pubmed: 25611886
J Gastrointest Surg. 2021 Jul;25(7):1760-1769
pubmed: 32728822
Clin Transplant. 2019 Dec;33(12):e13740
pubmed: 31651048
ACG Case Rep J. 2021 May 12;8(5):e00582
pubmed: 34549060
Liver Transpl. 2017 Oct;23(10):1266-1272
pubmed: 28691231
N Engl J Med. 1993 Dec 16;329(25):1842-7
pubmed: 8247035
Am J Transplant. 2013 Feb;13(2):353-62
pubmed: 23137006
Transplantation. 2007 May 27;83(10):1341-4
pubmed: 17519784
J Hepatol. 2022 Aug;77(2):503-515
pubmed: 35398460
PLoS One. 2017 Nov 16;12(11):e0188190
pubmed: 29145470
Am J Gastroenterol. 2013 Jun;108(6):942-8
pubmed: 23629601
Pathogens. 2022 Apr 27;11(5):
pubmed: 35631038
Frontline Gastroenterol. 2018 Jan;9(1):79-84
pubmed: 29484165
Transpl Infect Dis. 2020 Aug;22(4):e13275
pubmed: 32144838
Am J Transplant. 2020 Jan;20 Suppl s1:193-299
pubmed: 31898413
J Viral Hepat. 2018 Dec;25(12):1576-1581
pubmed: 30009520
Liver Transpl. 2013 Sep;19(9):1030-5
pubmed: 23788470
Liver Transpl. 2016 Sep;22(9):1205-13
pubmed: 27272189
Hepatology. 2002 Jan;35(1):176-81
pubmed: 11786974
J Hepatol. 2017 Nov;67(5):918-924
pubmed: 28736139
Ann Intern Med. 1983 Apr;98(4):437-41
pubmed: 6340574