Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.

Humans Epitopes HIV-1 CD4-Positive T-Lymphocytes CD4 Antigens / metabolism HIV Seropositivity Antibody-Dependent Cell Cytotoxicity HIV Envelope Protein gp120 / metabolism HIV Infections HIV Antibodies
HIV-1 Phe43 cavity antibody-dependent cellular cytotoxicity (ADCC) envelope glycoproteins neutralization small CD4 mimetic compounds (CD4mc)

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
17 05 2023
Historique:
received: 11 04 2023
revised: 09 05 2023
accepted: 15 05 2023
medline: 29 5 2023
pubmed: 27 5 2023
entrez: 27 5 2023
Statut: epublish

Résumé

The ability of the HIV-1 accessory proteins Nef and Vpu to decrease CD4 levels contributes to the protection of infected cells from antibody-dependent cellular cytotoxicity (ADCC) by preventing the exposure of Env vulnerable epitopes. Small-molecule CD4 mimetics (CD4mc) based on the indane and piperidine scaffolds such as (+)-BNM-III-170 and (

Identifiants

DOI: 10.3390/v15051185 PMID: 37243271 PMC: PMC10220648
pubmed: 37243271
pii: v15051185
doi: 10.3390/v15051185
pmc: PMC10220648
pii:
doi:

Substances chimiques

Epitopes 0
CD4 Antigens 0
HIV Envelope Protein gp120 0
HIV Antibodies 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI148379
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129769
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150322
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM056550
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164562
Pays : United States

Commentaires et corrections

Type : UpdateOf

Références

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Auteurs

Shilei Ding (S)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.

William D Tolbert (WD)

Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Huile Zhu (H)

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.

Daniel Lee (D)

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
ORCID: 0000-0002-7322-1512

Lorie Marchitto (L)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H3T 1J4, Canada.

Tyler Higgins (T)

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.

Xuchen Zhao (X)

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.

Dung Nguyen (D)

Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Rebekah Sherburn (R)

Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Jonathan Richard (J)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H3T 1J4, Canada.

Gabrielle Gendron-Lepage (G)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.

Halima Medjahed (H)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.

Mohammadjavad Mohammadi (M)

Department of Chemical and Biological Engineering, Drexel University, Philadelphia, PA 19104, USA.
ORCID: 0000-0001-7344-0857

Cameron Abrams (C)

Department of Chemical and Biological Engineering, Drexel University, Philadelphia, PA 19104, USA.

Marzena Pazgier (M)

Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
ORCID: 0000-0003-0594-5057

Amos B Smith (AB)

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.

Andrés Finzi (A)

Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada.
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H3T 1J4, Canada.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD4 › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Séropositivité VIH › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Phénomènes du système immunitaire › Cytotoxicité immunologique › Cytotoxicité à médiation cellulaire dépendante des anticorps › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Antigènes du VIH › Protéine d'enveloppe gp120 du VIH › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Piperidine CD4-Mimetic Compounds Expose...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Anticorps antideltarétrovirus › Anticorps anti-VIH › Piperidine CD4-Mimetic Compounds Expose...