Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems.
biodegradable
drug delivery
in situ forming implant
mathematical modeling
microspheres
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
09
05
2023
received:
21
02
2023
pmc-release:
01
12
2024
medline:
22
12
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
ppublish
Résumé
Implantable, bioresorbable drug delivery systems offer an alternative to current drug administration techniques; allowing for patient-tailored drug dosage, while also increasing patient compliance. Mechanistic mathematical modeling allows for the acceleration of the design of the release systems, and for prediction of physical anomalies that are not intuitive and may otherwise elude discovery. This study investigates short-term drug release as a function of water-mediated polymer phase inversion into a solid depot within hours to days, as well as long-term hydrolysis-mediated degradation and erosion of the implant over the next few weeks. Finite difference methods are used to model spatial and temporal changes in polymer phase inversion, solidification, and hydrolysis. Modeling reveals the impact of non-uniform drug distribution, production and transport of H
Identifiants
pubmed: 37243452
doi: 10.1002/adma.202301698
pmc: PMC10697660
mid: NIHMS1930776
doi:
Substances chimiques
Polymers
0
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301698Subventions
Organisme : NCATS NIH HHS
ID : U01 TR004239
Pays : United States
Organisme : NIBIB NIH HHS
ID : R03EB026231
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA048074
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA198929
Pays : United States
Organisme : NIBIB NIH HHS
ID : R03 EB026231
Pays : United States
Organisme : NCI NIH HHS
ID : R00CA198929
Pays : United States
Organisme : NIH HHS
Pays : United States
Informations de copyright
© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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