Analysis of serum metabolome of laborers exposure to welding fume.
Lysophosphatidylcholine
Metabolic profiling
Metabolomics
Phosphatidylglycerol
Welding fume
Journal
International archives of occupational and environmental health
ISSN: 1432-1246
Titre abrégé: Int Arch Occup Environ Health
Pays: Germany
ID NLM: 7512134
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
03
02
2023
accepted:
18
05
2023
medline:
24
7
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
ppublish
Résumé
Welding fume exposure is inevitable of welding workers and poses a severe hazard to their health since welding is a necessary industrial process. Thus, preclinical diagnostic symptoms of worker exposure are of great importance. The aim of this study was to screen serum differential metabolites of welding fume exposure based on UPLC-QTOF-MS/MS. In 2019, 49 participants were recruited at a machinery manufacturing factory. The non-target metabolomics technique was used to clarify serum metabolic signatures in people exposed to welding fume. Differential metabolites were screened by OPLS-DA analysis and Student's t-test. The receiver operating characteristic curve evaluated the discriminatory power of differential metabolites. And the correlations between differential metabolites and metal concentrations in urine and whole blood were analyzed utilizing Pearson correlation analysis. Thirty metabolites were increased significantly, and 5 metabolites were decreased. The differential metabolites are mainly enriched in the metabolism of arachidonic acid, glycero phospholipid, linoleic acid, and thiamine. These results observed that lysophosphatidylcholine (20:1/0:0) and phosphatidylglycerol(PGF1α/16:0) had a tremendous anticipating power with relatively increased AUC values (AUC > 0.9), and they also presented a significant correlation of Mo concentrations in whole blood and Cu concentrations in urine, respectively. The serum metabolism was changed significantly after exposure to welding fume. Lysophosphatidylcholine (20:1/0:0) and phosphatidylglycerol (PGF1α/16:0) may be a potential biological mediator and biomarker for laborers exposure to welding fume.
Identifiants
pubmed: 37243737
doi: 10.1007/s00420-023-01987-4
pii: 10.1007/s00420-023-01987-4
doi:
Substances chimiques
Air Pollutants, Occupational
0
Lysophosphatidylcholines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1029-1037Subventions
Organisme : Key Technology Project of State Administration of Work Safety
ID : 2017005
Organisme : National Center for Occupational Safety and Health Self-management Project of China
ID : 2019009
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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