Long-term effects of prenatal arsenic exposure from gestational day 9 to birth on lung, heart, and immune outcomes in the C57BL/6 mouse model.
Animal model
Arsenic
Developmental (or pregnancy)
Immunotoxicity
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
01 Jul 2023
01 Jul 2023
Historique:
received:
20
10
2022
revised:
21
04
2023
accepted:
22
05
2023
pmc-release:
01
07
2024
medline:
31
7
2023
pubmed:
28
5
2023
entrez:
27
5
2023
Statut:
ppublish
Résumé
Prenatal arsenic exposure is a major public health concern, associated with altered birth outcomes and increased respiratory disease risk. However, characterization of the long-term effects of mid-pregnancy (second trimester) arsenic exposure on multiple organ systems is scant. This study aimed to characterize the long-term impact of mid-pregnancy inorganic arsenic exposure on the lung, heart, and immune system, including infectious disease response using the C57BL/6 mouse model. Mice were exposed from gestational day 9 till birth to either 0 or 1000 µg/L sodium (meta)arsenite in drinking water. Male and female offspring assessed at adulthood (10-12 weeks of age) did not show significant effects on recovery outcomes after ischemia reperfusion injury but did exhibit increased airway hyperresponsiveness compared to controls. Flow cytometric analysis revealed significantly greater total numbers of cells in arsenic-exposed lungs, lower MHCII expression in natural killer cells, and increased percentages of dendritic cell populations. Activated interstitial (IMs) and alveolar macrophages (AMs) isolated from arsenic-exposed male mice produced significantly less IFN-γ than controls. Conversely, activated AMs from arsenic-exposed females produced significantly more IFN-γ than controls. Although systemic cytokine levels were higher upon Mycobacterium tuberculosis (Mtb) infection in prenatally arsenic-exposed offspring there was no difference in lung Mtb burden compared to controls. This study highlights significant long-term impacts of prenatal arsenic exposure on lung and immune cell function. These effects may contribute to the elevated risk of respiratory diseases associated with prenatal arsenic exposure in epidemiology studies and point to the need for more research into mechanisms driving these maintained responses.
Identifiants
pubmed: 37244563
pii: S0378-4274(23)00186-8
doi: 10.1016/j.toxlet.2023.05.011
pmc: PMC10527152
mid: NIHMS1908806
pii:
doi:
Substances chimiques
Arsenic
N712M78A8G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-32Subventions
Organisme : NIEHS NIH HHS
ID : R00 ES024808
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136496
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007141
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007534
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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