Maternal Prenatal Risk Phenotypes and Neurobehavioral Outcomes among Infants Born Very Preterm.
neurobehavior
phenotype
prenatal
preterm birth
risk factor
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
01
11
2022
revised:
16
05
2023
accepted:
21
05
2023
pmc-release:
01
09
2024
medline:
11
9
2023
pubmed:
28
5
2023
entrez:
27
5
2023
Statut:
ppublish
Résumé
To assess whether prenatal risk phenotypes are associated with neurobehavioral impairment for children born <30 weeks of gestation at discharge from the neonatal intensive care unit (NICU) and at 24-month follow-up. We studied infants from the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) study, a multisite investigation of infants born <30 weeks of gestation. There were 704 newborns enrolled in the NOVI study; of these, 679 (96%) had neonatal neurobehavioral data and 556 (79%) had 24-month follow-up data. Maternal prenatal phenotypes (physical and psychological risk groups) were characterized from 24 physical and psychological health risk factors. Neurobehavior was assessed at NICU discharge using the NICU Network Neurobehavioral Scales and at 2-year follow-up using the Bayley Scales of Infant and Toddler Development and the Child Behavior Checklist. Children born to mothers in the psychological risk group were at increased risk for dysregulated neonatal neurobehavior (OR, 2.04; 95% CI, 1.08-3.87) at NICU discharge, and for severe motor delay (OR, 3.80; 95% CI, 1.48-9.75), and clinically significant externalizing problems (OR, 2.54; 95% CI, 1.15-5.56) at age 24 months, compared with children born to mothers in the low-risk group. Children born to mothers in the physical risk group were more likely to have severe motor delay (OR, 2.70; 95% CI, 1.07-6.85) compared with the low-risk group. High-risk maternal prenatal phenotypes were associated with neurobehavioral impairment for children born very preterm. This information could identify newborns at risk for adverse neurodevelopmental outcomes.
Identifiants
pubmed: 37244578
pii: S0022-3476(23)00369-4
doi: 10.1016/j.jpeds.2023.113521
pmc: PMC10527115
mid: NIHMS1905897
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
113521Subventions
Organisme : NIMH NIH HHS
ID : K01 MH129510
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072267
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest This work was funded by the National Institutes of Health (NIH)/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) grant R01HD072267 (to B.M.L. and T.M.O.S.). M.C. was additionally supported by career development award from the National Institutes of Mental Health (NIMH), grant K01MH129510. The authors declare no conflicts of interest.
Références
J Child Adolesc Psychiatr Nurs. 2013 Aug;26(3):193-203
pubmed: 23909942
J Perinatol. 2022 Apr;42(4):483-490
pubmed: 35132152
Early Hum Dev. 2020 Mar;142:104954
pubmed: 32007912
Pediatr Res. 2022 May;91(6):1579-1586
pubmed: 34880445
Sci Rep. 2019 Apr 19;9(1):6322
pubmed: 31004082
J Marriage Fam. 2010 Jun;72(3):685-704
pubmed: 20676350
Pediatr Clin North Am. 2009 Jun;56(3):631-46, Table of Contents
pubmed: 19501696
J Child Psychol Psychiatry. 2003 Oct;44(7):1025-36
pubmed: 14531585
Pediatr Res. 2014 May;75(5):670-4
pubmed: 24492622
Pediatrics. 2004 Mar;113(3 Pt 2):641-67
pubmed: 14993524
Clin Epigenetics. 2021 Sep 10;13(1):171
pubmed: 34507616
Early Hum Dev. 2014 Sep;90(9):527-30
pubmed: 24819408
Pediatrics. 2009 Jan;123(1):313-8
pubmed: 19117897
Paediatr Perinat Epidemiol. 2008 Sep;22(5):438-66
pubmed: 18782252
JAMA Netw Open. 2022 Jul 1;5(7):e2222249
pubmed: 35849396
Pediatrics. 2007 Dec;120(6):e1512-9
pubmed: 17984212
Dev Psychopathol. 2018 Aug;30(3):721-724
pubmed: 30068432
Pediatr Res. 2017 Oct;82(4):614-619
pubmed: 28582386
Front Public Health. 2022 Jul 13;10:880339
pubmed: 35910895
Child Dev. 2016 Jan-Feb;87(1):211-20
pubmed: 26462448
Int J Environ Res Public Health. 2021 Feb 10;18(4):
pubmed: 33578786
Curr Opin Neurol. 2008 Apr;21(2):123-8
pubmed: 18317268
Pediatrics. 2005 Sep;116(3):635-43
pubmed: 16143580
Psychol Bull. 2004 Jan;130(1):115-42
pubmed: 14717652
Pediatr Res. 2020 Mar;87(4):721-729
pubmed: 31600769
Clin Neuropsychol. 2017 Feb;31(2):371-381
pubmed: 27687612
Dev Psychol. 1999 Sep;35(5):1297-310
pubmed: 10493655
Children (Basel). 2019 Dec 01;6(12):
pubmed: 31805647
J Pediatr. 2012 Dec;161(6):1073-9
pubmed: 22727876
J Child Psychol Psychiatry. 2003 Sep;44(6):810-8
pubmed: 12959490
Pediatrics. 2004 Mar;113(3 Pt 2):676-8
pubmed: 14993526
J Dev Behav Pediatr. 2019 Apr;40(3):200-207
pubmed: 30801416
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):23996-24005
pubmed: 31611411
J Child Neurol. 2012 Jan;27(1):22-9
pubmed: 22232137