Biometals in Alzheimer disease: emerging therapeutic and diagnostic potential of molybdenum and iodine.
Metallobiology
Neurodegeneration
Trace metal dyshomeostasis
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
27 05 2023
27 05 2023
Historique:
received:
08
04
2023
accepted:
20
05
2023
medline:
29
5
2023
pubmed:
28
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
The current ageing trend of the world population has, in part, accounted for Alzheimer disease (AD) being a public health issue in recent times. Although some progress has been made in clarifying AD-related pathophysiological mechanisms, effective intervention is still elusive. Biometals are indispensable to normal physiological functions of the human body-for example, neurogenesis and metabolism. However, their association with AD remains highly controversial. Copper (Cu) and zinc (Zn) are biometals that have been investigated at great length in relation to neurodegeneration, whereas less attention has been afforded to other trace biometals, such as molybdenum (Mo), and iodine. Given the above context, we reviewed the limited number of studies that have evidenced various effects following the usage of these two biometals in different investigative models of AD. Revisiting these biometals via thorough investigations, along with their biological mechanisms may present a solid foundation for not only the development of effective interventions, but also as diagnostic agents for AD.
Identifiants
pubmed: 37244993
doi: 10.1186/s12967-023-04220-5
pii: 10.1186/s12967-023-04220-5
pmc: PMC10224607
doi:
Substances chimiques
Trace Elements
0
Molybdenum
81AH48963U
Iodine
9679TC07X4
Zinc
J41CSQ7QDS
Copper
789U1901C5
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
351Informations de copyright
© 2023. The Author(s).
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