Harnessing transposable elements for cancer therapy.

Humans DNA Transposable Elements / genetics Neoplasms / genetics
cancer therapy epigenetic pan-cancer transposable element

Journal

Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956

Informations de publication

Date de publication:
07 2023
Historique:
received: 04 05 2023
accepted: 18 05 2023
medline: 23 6 2023
pubmed: 30 5 2023
entrez: 29 5 2023
Statut: ppublish

Résumé

Transposable elements (TEs) can move within the genome and can have a significant role in cancer development. Shah et al. recently identified that TEs have regulatory potentials and that tumor-specific TE-gene chimeric events that produce new isoforms of proteins could serve as universal cancer biomarkers and targets for cancer immunotherapy.

Identifiants

DOI: 10.1016/j.trecan.2023.05.005 PMID: 37248150
pubmed: 37248150
pii: S2405-8033(23)00096-1
doi: 10.1016/j.trecan.2023.05.005
pii:
doi:

Substances chimiques

DNA Transposable Elements 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

526-527

Subventions

Organisme : NHGRI NIH HHS
ID : R01 HG011633
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA262623
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests None declared by authors.

Auteurs

Yuan Liu (Y)

Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA; Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, IN, USA. Electronic address: yl218@iu.edu.

Leng Han (L)

Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA; Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, IN, USA; Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA; Brown Center for Immunotherapy, School of Medicine, Indiana University, Indianapolis, IN, USA. Electronic address: lenghan@iu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Harnessing transposable elements for cancer therapy.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées dispersées › Éléments transposables d'ADN › Harnessing transposable elements for cancer therapy.
questionsmedicales.fr › Tumeurs › Harnessing transposable elements for cancer therapy.