Prediabetes and skeletal health.
Journal
Current opinion in endocrinology, diabetes, and obesity
ISSN: 1752-2978
Titre abrégé: Curr Opin Endocrinol Diabetes Obes
Pays: England
ID NLM: 101308636
Informations de publication
Date de publication:
01 Aug 2023
01 Aug 2023
Historique:
medline:
3
7
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
ppublish
Résumé
Type 2 diabetes mellitus (T2D) confers a greater risk of skeletal fragility and fracture. Whether prediabetes is detrimental to bone health is uncertain. We summarize the current data on the associations of prediabetes with bone turnover, bone mineral density, bone quality, bone material properties and fracture risk. In cross-sectional studies, prediabetes was associated with lower bone turnover and worse trabecular bone quality. A longitudinal analysis showed that larger increase in insulin resistance (in the absence of T2D) correlated with faster bone loss. Future research to examine the longitudinal associations of prediabetes with bone health parameters is warranted.
Identifiants
pubmed: 37248797
doi: 10.1097/MED.0000000000000812
pii: 01266029-202308000-00005
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
200-205Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
Ji S, Jiang X, Han H, et al. Prediabetes and osteoporotic fracture risk: a meta-analysis of prospective cohort studies. Diabetes Metab Res Rev 2022; 38:e3568.
Tanaka K, Yamaguchi T, Kanazawa I, Sugimoto T. Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells. Biochem Biophys Res Commun 2015; 461:193–199.
Gortázar AR, Ardura JA. Osteocytes and diabetes: altered function of diabetic osteocytes. Curr Osteoporos Rep 2020; 18:796–802.
Bai X, Lu D, Bai J, et al. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun 2004; 314:197–207.
Hardouin P, Rharass T, Lucas S. Bone marrow adipose tissue: to be or not to be a typical adipose tissue? Front Endocrinol (Lausanne) 2016; 7:85.
Hamann C, Rauner M, Höhna Y, et al. Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus. J Bone Miner Res 2013; 28:627–638.
Ferron M, Wei J, Yoshizawa T, et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 2010; 142:296–308.
Cirovic A, Jadzic J, Djukic D, et al. Increased cortical porosity, reduced cortical thickness, and reduced trabecular and cortical microhardness of the superolateral femoral neck confer the increased hip fracture risk in individuals with Type 2 diabetes. Calcif Tissue Int 2022; 111:457–465.
Krakauer JC, McKenna MJ, Buderer NF, et al. Bone loss and bone turnover in diabetes. Diabetes 1995; 44:775–782.
Manavalan JS, Cremers S, Dempster DW, et al. Circulating osteogenic precursor cells in type 2 diabetes mellitus. J Clin Endocrinol Metab 2012; 97:3240–3250.
Napoli N, Chandran M, Pierroz DD, et al. Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol 2017; 13:208–219.
Mitchell A, Fall T, Melhus H, et al. Type 2 diabetes in relation to hip bone density, area, and bone turnover in Swedish men and women: a cross-sectional study. Calcif Tissue Int 2018; 103:501–511.
Jiajue R, Jiang Y, Wang O, et al. Suppressed bone turnover was associated with increased osteoporotic fracture risks in nonobese postmenopausal Chinese women with type 2 diabetes mellitus. Osteoporos Int 2014; 25:1999–2005.
Holloway-Kew KL, Betson A, Rufus-Membere PG, et al. Impact microindentation in men with impaired fasting glucose and type 2 diabetes. Bone 2021; 142:115685.
van Bezooijen RL, ten Dijke P, Papapoulos SE, Löwik CWGM. SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine Growth Factor Rev 2005; 16:319–327.
Liu B, Liu J, Pan J, et al. The association of diabetes status and bone mineral density among US adults: evidence from NHANES 2005–2018. BMC Endocr Disord 2023; 23:27.
Lee JH, Lee YH, Jung KH, et al. Bone mineral density in prediabetic men. Korean Diabetes J 2010; 34:294–302.
Newton-John HF, Morgan DB. The loss of bone with age, osteoporosis, and fractures. Clin Orthop Relat Res 1970; 71:229–252.
Choo MS, Choi SR, Han JH, et al. Association of insulin resistance with near peak bone mass in the femur and lumbar spine of Korean adults aged 25–35: the Korean National Health and Nutrition Examination Survey 2008–2010. PLoS One 2008-2010; 12:e0177311.
Shieh A, Greendale GA, Cauley JA, et al. Longitudinal associations of insulin resistance with change in bone mineral density in midlife women. JCI Insight 2022; 7:e162085.
Silva BC, Leslie WD, Resch H, et al. Trabecular bone score: a noninvasive analytical method based upon the DXA image. J Bone Miner Res 2014; 29:518–530.
Hildebrand, Rüegsegger P. A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc 1997; 185:67–75.
Ebrahimpur M, Sharifi F, Nezhad FA, et al. Effect of diabetes on BMD and TBS values as determinants of bone health in the elderly: Bushehr Elderly Health program. J Diabetes Metab Disord 2019; 18:99–106.
Holloway KL, De Abreu LLF, Hans D, et al. Trabecular bone score in men and women with impaired fasting glucose and diabetes. Calcif Tissue Int 2018; 102:32–40.
Lui DTW, Lee CH, Chau VWK, et al. Potential role of fibroblast growth factor 21 in the deterioration of bone quality in impaired glucose tolerance. J Endocrinol Invest 2021; 44:523–530.
Campillo-Sánchez F, Usategui-Martín R, Ruiz-de Temiño Á, et al. Relationship between insulin resistance (HOMA-IR), trabecular bone score (TBS), and three-dimensional Dual-energy X-ray absorptiometry (3D-DXA) in non-diabetic postmenopausal women. J Clin Med 2020; 9:1732.
Ho-Pham LT, Tran B, Do AT, Nguyen TV. Association between prediabetes, type 2 diabetes and trabecular bone score: the Vietnam Osteoporosis Study. Diabetes Res Clin Pract 2019; 155:107790.
Ho-Pham LT, Nguyen TV. Association between trabecular bone score and type 2 diabetes: a quantitative update of evidence. Osteoporos Int 2019; 30:2079–2085.
Shieh A, Greendale GA, Cauley JA, et al. Prediabetes and insulin resistance are associated with lower trabecular bone score (TBS): cross-sectional results from the Study of Women's Health Across the Nation TBS Study. Osteoporos Int 2022; 33:1365–1372.
Tang Y, Zhang M. Fibroblast growth factor 21 and bone homeostasis. Biomed J 2022; S2319-4170(22)00102-0. doi: 10.1016/j.bj.2022.07.002. [Epub ahead of print].
doi: 10.1016/j.bj.2022.07.002.
de Waard EAC, de Jong JJA, Koster A, et al. The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomography: the Maastricht Study. Osteoporos Int 2018; 29:2725–2738.
Bridges D, Randall C, Hansma PK. A new device for performing reference point indentation without a reference probe. Rev Sci Instrum 2012; 83:044301.
Dawson-Hughes B, Bouxsein M, Shea K. Bone material strength in normoglycemic and hyperglycemic black and white older adults. Osteoporos Int 2019; 30:2429–2435.
Samakkarnthai P, Sfeir JG, Atkinson EJ, et al. Determinants of bone material strength and cortical porosity in patients with Type 2 diabetes mellitus. J Clin Endocrinol Metab 2020; 105:e3718–e3729.
Phimphilai M, Pothacharoen P, Chattipakorn N, Kongtawelert P. Receptors of advanced glycation end product (RAGE) suppression associated with a preserved osteogenic differentiation in patients with prediabetes. Front Endocrinol 2022; 13:799872.
Looker AC, Sarafrazi IN, Fan B, Shepherd JA. Trabecular bone scores and lumbar spine bone mineral density of US adults: comparison of relationships with demographic and body size variables. Osteoporos Int 2016; 27:2467–2475.
Napoli N, Strotmeyer ES, Ensrud K, et al. Fracture risk in diabetic elderly men: the MrOS study. Diabetologia 2014; 57:2057–2065.
Park HY, Han K, Kim Y, et al. The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes: a longitudinal nationwide population-based study. Bone 2021; 142:115691.
Kirthi V, Perumbalath A, Brown E, et al. Prevalence of peripheral neuropathy in prediabetes: a systematic review. BMJ Open Diabetes Res Care 2021; 9:e002040.
Centers for Disease Control and Prevention. Prevalence of prediabetes among adults. https://www.cdc.gov/diabetes/data/statistics-report/prevalence-of-prediabetes.html#print . [Accessed 6 March 2023].