Gate control of sensory neurotransmission in peripheral ganglia by proprioceptive sensory neurons.
dorsal root ganglia
gamma-aminobutyric acid
gate control
nociception
parvalbumin
Journal
Brain : a journal of neurology
ISSN: 1460-2156
Titre abrégé: Brain
Pays: England
ID NLM: 0372537
Informations de publication
Date de publication:
03 10 2023
03 10 2023
Historique:
received:
28
10
2022
revised:
12
04
2023
accepted:
18
05
2023
medline:
4
10
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
ppublish
Résumé
Melzak and Wall's gate control theory proposed that innocuous input into the dorsal horn of the spinal cord represses pain-inducing nociceptive input. Here we show that input from proprioceptive parvalbumin-expressing sensory neurons tonically represses nociceptor activation within dorsal root ganglia. Deletion of parvalbumin-positive sensory neurons leads to enhanced nociceptor activity measured with GCaMP3, increased input into wide dynamic range neurons of the spinal cord and increased acute and spontaneous pain behaviour, as well as potentiated innocuous sensation. Parvalbumin-positive sensory neurons express the enzymes and transporters necessary to produce vesicular GABA that is known to be released from depolarized somata. These observations support the view that gate control mechanisms occur peripherally within dorsal root ganglia.
Identifiants
pubmed: 37249190
pii: 7186228
doi: 10.1093/brain/awad182
pmc: PMC10549771
doi:
Substances chimiques
Parvalbumins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4033-4039Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 200183/Z/15/Z
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21950
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21734
Pays : United Kingdom
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.
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