Adiponectin/leptin and HOMA/adiponectin ratios in Iranian women with polycystic ovary syndrome.
Adiponectin
Adiponectin/leptin ratio
Homeostasis model assessment for insulin resistance/adiponectin
Leptin
Polycystic ovary syndrome
Journal
Irish journal of medical science
ISSN: 1863-4362
Titre abrégé: Ir J Med Sci
Pays: Ireland
ID NLM: 7806864
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
07
03
2023
accepted:
18
05
2023
medline:
1
8
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
ppublish
Résumé
Insulin resistance and disrupted secretion of adipokines are the major contributors to the pathogenesis of polycystic ovary syndrome (PCOS). Previous research has indicated that adiponectin/leptin (A/L) and HOMA/adiponectin (H/A) ratios have a strong association with insulin resistance and metabolic syndrome. The current study aimed to assess the predictability of the A/L and H/A ratios for PCOS women infertility and recurrent pregnancy loss (RPL). In this study, we investigated the association of A/L and H/A ratios with PCOS, as well as infertility and RPL in Iranian women with PCOS. This case-control study included 150 PCOS (60 infertile and 90 PCOS-RPL) and 50 non-PCOS women. Clinical, biochemical, and hormonal features were evaluated, and the A/L and H/A ratios were calculated. The A/L and H/A ratios were significantly decreased and increased in women with PCOS, respectively. A significant association was observed between the A/L and H/A ratios with PCOS, as well as PCOS-infertile and PCOS-RPL, even after adjusting for potential confounders. Although there was no significant difference between PCOS-infertile and PCOS-RPL subgroups, ROC curve analysis showed that A/L and H/A ratios could strongly predict PCOS with the area under the curve (AUC) of 0.867 and 0.861, respectively. The ratios of A/L and H/A may serve as biomarkers to distinguish women with PCOS from non-PCOS in the Iranian population. However, it seems that they are not discriminatory markers for PCOS-associated RPL and infertility.
Sections du résumé
BACKGROUND
BACKGROUND
Insulin resistance and disrupted secretion of adipokines are the major contributors to the pathogenesis of polycystic ovary syndrome (PCOS). Previous research has indicated that adiponectin/leptin (A/L) and HOMA/adiponectin (H/A) ratios have a strong association with insulin resistance and metabolic syndrome. The current study aimed to assess the predictability of the A/L and H/A ratios for PCOS women infertility and recurrent pregnancy loss (RPL). In this study, we investigated the association of A/L and H/A ratios with PCOS, as well as infertility and RPL in Iranian women with PCOS.
METHODS
METHODS
This case-control study included 150 PCOS (60 infertile and 90 PCOS-RPL) and 50 non-PCOS women. Clinical, biochemical, and hormonal features were evaluated, and the A/L and H/A ratios were calculated.
RESULTS
RESULTS
The A/L and H/A ratios were significantly decreased and increased in women with PCOS, respectively. A significant association was observed between the A/L and H/A ratios with PCOS, as well as PCOS-infertile and PCOS-RPL, even after adjusting for potential confounders. Although there was no significant difference between PCOS-infertile and PCOS-RPL subgroups, ROC curve analysis showed that A/L and H/A ratios could strongly predict PCOS with the area under the curve (AUC) of 0.867 and 0.861, respectively.
CONCLUSION
CONCLUSIONS
The ratios of A/L and H/A may serve as biomarkers to distinguish women with PCOS from non-PCOS in the Iranian population. However, it seems that they are not discriminatory markers for PCOS-associated RPL and infertility.
Identifiants
pubmed: 37249791
doi: 10.1007/s11845-023-03408-4
pii: 10.1007/s11845-023-03408-4
doi:
Substances chimiques
Leptin
0
Adiponectin
0
Insulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1793-1799Informations de copyright
© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.
Références
The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81:19–25
doi: 10.1016/j.fertnstert.2003.10.004
Brassard M, AinMelk Y, Baillargeon J-P (2008) Basic infertility including polycystic ovary syndrome. Med Clin North Am 92:1163–1192
doi: 10.1016/j.mcna.2008.04.008
pubmed: 18721657
Koivunen R, Laatikainen T, Tomás C et al (1999) The prevalence of polycystic ovaries in healthy women. Acta Obstet Gynecol Scand 78:137–141
pubmed: 10023877
Mannerås-Holm L, Leonhardt H, Kullberg J et al (2011) Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance. J Clin Endocrinol Metab 96:E304–E311
doi: 10.1210/jc.2010-1290
pubmed: 21084397
Vega GL, Grundy SM (2013) Metabolic risk susceptibility in men is partially related to adiponectin/leptin ratio. J Obes
Mitchell M, Armstrong D, Robker R, Norman R (2005) Adipokines: implications for female fertility and obesity. Reproduction 130:583–597
doi: 10.1530/rep.1.00521
pubmed: 16264089
Cao H (2014) Adipocytokines in obesity and metabolic disease. J Endocrinol 220:T47–T59
doi: 10.1530/JOE-13-0339
pubmed: 24403378
pmcid: 3887367
Ali AT (2015) Polycystic ovary syndrome and metabolic syndrome. Ceska Gynekol 80:279–289
pubmed: 26265416
Frühbeck G, Catalán V, Rodríguez A, Gómez-Ambrosi J (2018) Adiponectin-leptin ratio: a promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk Adipocyte 7:57–62
pubmed: 29205099
Yamauchi T, Kamon J, Waki H et al (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941–946
doi: 10.1038/90984
pubmed: 11479627
Makni E, Moalla W, Lac G et al (2012) The Homeostasis Model Assessment-adiponectin (HOMA-AD) is the most sensitive predictor of insulin resistance in obese children. In Annales d'endocrinologie 73:26–33
Matsuhisa M, Yamasaki Y, Emoto M et al (2007) A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. Diabetes Res Clin Pract 77:151–154
doi: 10.1016/j.diabres.2006.10.005
pubmed: 17081646
Jung C-H, Rhee E-J, Choi J-H et al (2010) The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy Korean male adults. Korean Diabetes J 34:237–243
doi: 10.4093/kdj.2010.34.4.237
pubmed: 20835341
pmcid: 2932893
Zaletel J, Pongrac Barlovic D, Prezelj J (2010) Adiponectin-leptin ratio: a useful estimate of insulin resistance in patients with Type 2 diabetes. J Endocrinol Invest 33:514–518
doi: 10.1007/BF03346639
pubmed: 20142631
Sadeghi A, Fadaei R, Moradi N et al (2020) Circulating levels of C1q/TNF-α-related protein 6 (CTRP6) in polycystic ovary syndrome. IUBMB Life 72:1449–1459
doi: 10.1002/iub.2272
pubmed: 32170998
Fouani FZ, Fadaei R, Moradi N et al (2020) Circulating levels of Meteorin-like protein in polycystic ovary syndrome: a case-control study. PLoS ONE 15:e0231943
doi: 10.1371/journal.pone.0231943
pubmed: 32330176
pmcid: 7182262
Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41–47
doi: 10.1093/humrep/deh098
Lee RM, Silver RM (2000) Recurrent pregnancy loss: summary and clinical recommendations. Semin Reprod Med 18:433–440
Kargasheh FB, Ansaripour S, Borumandnia N et al (2021) Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome. PLoS ONE 16:e0255920
doi: 10.1371/journal.pone.0255920
pubmed: 34407095
pmcid: 8372961
Randeva HS, Tan BK, Weickert MO et al (2012) Cardiometabolic aspects of the polycystic ovary syndrome. Endocr Rev 33:812–841
doi: 10.1210/er.2012-1003
pubmed: 22829562
pmcid: 3461136
Serazin V, Duval F, Wainer R et al (2018) Are leptin and adiponectin involved in recurrent pregnancy loss? J Obstet Gynaecol Res 44:1015–1022
doi: 10.1111/jog.13623
pubmed: 29536593
Obirikorang C, Owiredu WK, Adu-Afram S et al (2019) Assessing the variability and predictability of adipokines (adiponectin, leptin, resistin and their ratios) in non-obese and obese women with anovulatory polycystic ovary syndrome. BMC Res Notes 12:1–8
doi: 10.1186/s13104-019-4546-z
Baldani DP, Skrgatic L, Kasum M et al (2019) Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality. Gynecol Endocrinol 35:401–405
doi: 10.1080/09513590.2018.1534096
pubmed: 30623695
Golbahar J, Das NM, Al-Ayadhi MA, Gumaa K (2012) Leptin-to-adiponectin, adiponectin-to-leptin ratios, and insulin are specific and sensitive markers associated with polycystic ovary syndrome: a case–control study from Bahrain. Metab Syndr Relat Disord 10:98–102
doi: 10.1089/met.2011.0075
pubmed: 22107332
Sarray S, Madan S, Saleh LR et al (2015) Validity of adiponectin-to-leptin and adiponectin-to-resistin ratios as predictors of polycystic ovary syndrome. Fertil Steril 104:460–466
doi: 10.1016/j.fertnstert.2015.05.007
pubmed: 26051098
Xiang S-K, Hua F, Tang Y et al (2012) Relationship between serum lipoprotein ratios and insulin resistance in polycystic ovary syndrome. Int J Endocrinol
De Luis DA, Aller R, Izaola O et al (2011) The ratio of adiponectin to HOMA as an index of metabolic syndrome in obese women. Ann Nutr Metab 58:301–306
doi: 10.1159/000331216
pubmed: 21912107
Xu X, Lai Y, Yang G et al (2016) Adiponectin/(FBG × FIns) as a predictor of insulin sensitivity and metabolic syndrome in patients with polycystic ovary syndrome. Medicine 95
Meera S, Senghor KA, Vinodhini V, Sunitha S (2019) Role of adiponectin and insulin resistance in android and gynoid obese infertile women. Obes Med 16:100130
doi: 10.1016/j.obmed.2019.100130
Senghor KA, Vinodhini V (2020) Evaluation of Leptin and HOMA-adiponectin in hypothyroid infertile females. Biomed Pharmacol J 13:1931–1937
doi: 10.13005/bpj/2071
Lage M, Garcia-Mayor RV, Tomé MA et al (1999) Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion. Clin Endocrinol 50:211–216
doi: 10.1046/j.1365-2265.1999.00637.x
Tommaselli GA, Di Spiezio SA, Di Carlo C et al (2006) Do serum leptin levels have a role in the prediction of pregnancy outcome in case of threatened miscarriage? Clin Endocrinol 65:772–775
doi: 10.1111/j.1365-2265.2006.02665.x
Agostinis-Sobrinho C, Vicente SEDCF, Norkiene S et al (2022) Is the leptin/adiponectin ratio a better diagnostic biomarker for insulin resistance than leptin or adiponectin alone in adolescents? Children 9:1193
doi: 10.3390/children9081193
pubmed: 36010082
pmcid: 9406389
Lu M, Tang Q, Olefsky JM et al (2008) Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LβT2 gonadotropes. Mol Endocrinol 22:760–771
doi: 10.1210/me.2007-0330
pubmed: 18006641