Cognitive Outcome After Islet Transplantation.
Journal
Transplantation direct
ISSN: 2373-8731
Titre abrégé: Transplant Direct
Pays: United States
ID NLM: 101651609
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
10
10
2022
revised:
21
03
2023
accepted:
07
04
2023
medline:
30
5
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
epublish
Résumé
Severe or repeated hypoglycemia events may favor memory complaints in type 1 diabetes (T1D). Pancreatic islet transplantation (IT) is an alternative option to exogenous insulin therapy in case of labile T1D, implying a maintenance immunosuppression regimen based on sirolimus or mycophenolate, associated with tacrolimus, that may also have neurological toxicity. The objective of this study was to compare a cognitive rating scale Mini-Mental State Examination (MMSE) between T1D patients with or without IT and to identify parameters influencing MMSE. This retrospective cross-sectional study compared MMSE and cognitive function tests between islet-transplanted T1D patients and nontransplanted T1D controls who were transplant candidates. Patients were excluded if they refused. Forty-three T1D patients were included: 9 T1D patients before IT and 34 islet-transplanted patients (14 treated with mycophenolate and 20 treated with sirolimus). Neither MMSE score ( This first study evaluating cognitive disorders in islet-transplanted T1D patients argues for the importance of glucose balance on cognitive function rather than of immunosuppressive treatment, with a favorable effect of glucose balance improvement on MMSE score after IT.
Identifiants
pubmed: 37250488
doi: 10.1097/TXD.0000000000001493
pmc: PMC10219717
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e1493Informations de copyright
Copyright © 2023 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Horm Res Paediatr. 2021;94(3-4):115-123
pubmed: 34247158
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Int Neuropsychol Soc. 2009 Sep;15(5):684-94
pubmed: 19570307
Am J Nephrol. 2011;34(5):399-406
pubmed: 21934300
Presse Med. 1999 Jun 12;28(21):1141-8
pubmed: 10399508
Lancet Diabetes Endocrinol. 2021 Jul;9(7):436-445
pubmed: 34051936
Lancet Diabetes Endocrinol. 2018 Jul;6(7):527-537
pubmed: 29776895
Diabetes Res Clin Pract. 2021 Jul;177:108898
pubmed: 34098058
PLoS One. 2015 Jul 01;10(7):e0132118
pubmed: 26132234
J Clin Endocrinol Metab. 2019 Jun 1;104(6):2239-2249
pubmed: 30657922
Chem Res Toxicol. 2010 Mar 15;23(3):608-19
pubmed: 20148532
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Front Psychiatry. 2021 Dec 02;12:773281
pubmed: 34925100
Nephrol Dial Transplant. 2018 Jul 1;33(7):1268-1277
pubmed: 28992229
Transpl Immunol. 2020 Feb;58:101248
pubmed: 31669260
Diabetes Care. 2005 May;28(5):1245-9
pubmed: 15855602
Heart Lung. 2014 Sep-Oct;43(5):462-8
pubmed: 25035250
Transplantation. 2002 Mar 27;73(6):901-6
pubmed: 11923689
Lancet. 2019 Oct 5;394(10205):1274-1285
pubmed: 31533905
BMC Psychiatry. 2021 Oct 4;21(1):485
pubmed: 34607584
Diabetologia. 2021 May;64(5):971-977
pubmed: 33738528
Cell Biol Toxicol. 2013 Dec;29(6):407-14
pubmed: 24077807
J Appl Gerontol. 2022 Apr;41(4):1222-1231
pubmed: 34856843
N Engl J Med. 2010 Oct 7;363(15):1410-8
pubmed: 20925543
Lancet Diabetes Endocrinol. 2021 Jul;9(7):411-412
pubmed: 34051937
Am J Transplant. 2018 Mar;18(3):696-703
pubmed: 29087035
Diabetol Int. 2019 Oct 03;11(2):114-120
pubmed: 32206481
Cochrane Database Syst Rev. 2021 Jul 27;7:CD010783
pubmed: 34313331
J Intern Med. 2013 Jan;273(1):102-10
pubmed: 23003116
Transplantation. 2018 Sep;102(9):1479-1486
pubmed: 29528967
Curr Diab Rep. 2021 Mar 14;21(4):12
pubmed: 33715053
Ther Adv Endocrinol Metab. 2020 Feb 14;11:2042018820906017
pubmed: 32110374
Am J Transplant. 2012 Sep;12(9):2519-25
pubmed: 22548872
Diabetes Care. 2015 Dec;38(12):2354-69
pubmed: 26604281
Int J Geriatr Psychiatry. 2018 Jul;33(7):972-979
pubmed: 29575215
Lancet Diabetes Endocrinol. 2022 Feb;10(2):90-92
pubmed: 34951951
Nephrol Dial Transplant. 2004 Jul;19(7):1866-74
pubmed: 15150346
Clin Transplant. 2017 Dec;31(12):
pubmed: 29055147
Diabetes Care. 2005 Mar;28(3):726-35
pubmed: 15735218
Mol Cell Endocrinol. 2021 Apr 15;526:111192
pubmed: 33545179
Diabetes Care. 2019 Nov;42(11):2042-2049
pubmed: 31615852