Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population.
Age
Behavioral neuroscience
Human metabolism
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
received:
30
08
2022
revised:
13
02
2023
accepted:
20
04
2023
medline:
30
5
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
epublish
Résumé
Dysregulations in cholesterol metabolism are associated with neurodegenerative and vascular pathologies, and dementia. Diet-derived plant sterols (phytosterols) have cholesterol-lowering, anti-inflammatory, and antioxidant properties and may interfere with neurodegeneration and cognitive decline. Here we performed multivariate analysis in 720 individuals enrolled in a population-based prospective study to determine whether circulating cholesterol precursors and metabolites, triglycerides, and phytosterols, are associated with cognitive impairment and decline in the older population. We report specific dysregulations of endogenous cholesterol synthesis and metabolism, and diet-derived phytosterols, and their changes over time associated with cognitive impairment, and decline in the general population. These findings suggest circulating sterols levels could be considered in risk evaluation and are relevant for the development of strategies to prevent cognitive decline in older people.
Identifiants
pubmed: 37250771
doi: 10.1016/j.isci.2023.106740
pii: S2589-0042(23)00817-9
pmc: PMC10209479
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106740Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
J.P. received consultation and speaker honoraria from Nestle Institute of Health Sciences, Innovation Campus, EPFL, Lausanne, Switzerland, Ono Pharma, Schwabe Pharma Switzerland, OM Pharma Switzerland, Roche Pharma, and from Fujirebio Europe. C.C. received consultation and speaker honoraria from OM Pharma Suisse. The other authors declare no conflicts of interest.
Références
NPJ Aging Mech Dis. 2021 Jun 1;7(1):11
pubmed: 34075056
Neurology. 2001 Oct 23;57(8):1447-52
pubmed: 11673587
Neurobiol Aging. 2009 Apr;30(4):534-45
pubmed: 17888546
J Neurochem. 2012 Oct;123(2):310-6
pubmed: 22845771
J Neurosci. 2013 Oct 9;33(41):16072-87
pubmed: 24107941
Plant Foods Hum Nutr. 2011 Jun;66(2):149-56
pubmed: 21431910
Transl Psychiatry. 2019 Jan 18;9(1):26
pubmed: 30659169
Chem Phys Lipids. 2016 Sep;199:144-160
pubmed: 26956952
J Alzheimers Dis. 2016;51(1):45-55
pubmed: 26836015
Ann Med. 2011 Jun;43(4):292-301
pubmed: 21254906
Am J Geriatr Psychiatry. 2016 Aug;24(8):604-612
pubmed: 27311886
Biochim Biophys Acta. 2010 Aug;1801(8):945-50
pubmed: 20226877
Neurotherapeutics. 2022 Jan;19(1):68-88
pubmed: 34939171
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Lipid Res. 2012 Mar;53(3):567-576
pubmed: 22203775
Dement Geriatr Cogn Disord. 2009;28(1):75-80
pubmed: 19648749
Arch Neurol. 2010 Dec;67(12):1491-7
pubmed: 21149810
Front Aging Neurosci. 2021 Jun 24;13:690372
pubmed: 34248607
Alzheimers Dement. 2018 Feb;14(2):167-177
pubmed: 28916238
Lipids Health Dis. 2016 Sep 05;15(1):146
pubmed: 27595570
J Alzheimers Dis. 2013;33(4):891-911
pubmed: 23076077
Neurology. 2007 Mar 6;68(10):751-6
pubmed: 17339582
J Steroid Biochem Mol Biol. 2019 Jun;190:104-114
pubmed: 30878503
Elife. 2015 Jun 26;4:e07999
pubmed: 26114596
Pharmacotherapy. 2009 Jul;29(7):800-11
pubmed: 19558254
Biochim Biophys Acta. 2010 Aug;1801(8):934-44
pubmed: 20359547
BMC Psychiatry. 2009 Mar 17;9:9
pubmed: 19292899
Curr Cardiol Rep. 2013 Sep;15(9):400
pubmed: 23881582
Biochem Pharmacol. 2013 Jul 1;86(1):37-42
pubmed: 23291240
J Exp Med. 2017 Mar 6;214(3):699-717
pubmed: 28213512
Neurosci Lett. 2001 Nov 13;314(1-2):45-8
pubmed: 11698143
Neurology. 2003 Jul 22;61(2):199-205
pubmed: 12874399
Am J Clin Nutr. 1999 Jun;69(6):1144-50
pubmed: 10357732
Front Aging Neurosci. 2017 Mar 14;9:63
pubmed: 28352228
J Biol Chem. 2004 Aug 13;279(33):34674-81
pubmed: 15148325
Int J Geriatr Psychiatry. 2009 Sep;24(9):921-6
pubmed: 19212968
Neurosci Lett. 2009 Oct 2;462(1):89-93
pubmed: 19560513
Endocrinology. 2008 Jul;149(7):3592-7
pubmed: 18403490
Clin Chem. 1972 Jun;18(6):499-502
pubmed: 4337382
Alzheimers Res Ther. 2021 Mar 6;13(1):56
pubmed: 33676572
Cardiovasc Res. 2014 Aug 1;103(3):405-13
pubmed: 24907980
Neurobiol Aging. 2003 Jan-Feb;24(1):147-55
pubmed: 12493560
Sci Rep. 2018 Apr 11;8(1):5804
pubmed: 29643479
Neuropsychology. 2017 Sep;31(6):682-688
pubmed: 28604016
Dement Geriatr Cogn Disord. 2005;19(5-6):256-65
pubmed: 15785028
J Neurol Sci. 2015 Mar 15;350(1-2):69-74
pubmed: 25703278
Redox Biol. 2021 Feb;39:101837
pubmed: 33360775
Future Lipidol. 2008 Oct;3(5):505-530
pubmed: 19649144
Arterioscler Thromb Vasc Biol. 2004 May;24(5):806-15
pubmed: 14764421
Mol Neurobiol. 2018 Oct;55(10):8179-8187
pubmed: 29516283
Curr Cardiol Rev. 2009 Aug;5(3):216-22
pubmed: 20676280
Protein Cell. 2015 Apr;6(4):254-64
pubmed: 25682154
Prog Lipid Res. 2015 Apr;58:26-39
pubmed: 25623279
Korean J Physiol Pharmacol. 2020 Jan;24(1):39-46
pubmed: 31908573
Pharmacology. 2010;86(1):15-21
pubmed: 20571288
Brain Sci. 2020 Jun 18;10(6):
pubmed: 32570800
J Lipid Res. 2000 Feb;41(2):195-8
pubmed: 10681402
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9799-804
pubmed: 8790411
Eur Arch Psychiatry Clin Neurosci. 1999;249(4):174-9
pubmed: 10449592
J Lipid Res. 2013 Apr;54(4):1033-43
pubmed: 23284090
J Steroid Biochem Mol Biol. 2021 Jan;205:105785
pubmed: 33171206
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7238-43
pubmed: 10377398
Acta Psychiatr Scand. 2011 Sep;124(3):184-92
pubmed: 21585343
Atherosclerosis. 2017 Oct;265:147-154
pubmed: 28888808
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
J Biol Chem. 2012 Jan 13;287(3):2032-44
pubmed: 22130662
BMC Cardiovasc Disord. 2008 Mar 17;8:6
pubmed: 18366642
Arch Neurol. 2004 May;61(5):705-14
pubmed: 15148148
Neuroscientist. 2016 Apr;22(2):132-44
pubmed: 25628343
J Lipid Res. 2005 May;46(5):1047-52
pubmed: 15741649
Transl Neurodegener. 2018 Feb 27;7:5
pubmed: 29507718