Acute lymphoblastic leukemia relapse presenting with optic nerve infiltration.
Acute lymphoblastic leukemia
optic nerve infiltration
radiation therapy
salvage treatment
Journal
SAGE open medical case reports
ISSN: 2050-313X
Titre abrégé: SAGE Open Med Case Rep
Pays: England
ID NLM: 101638686
Informations de publication
Date de publication:
2023
2023
Historique:
received:
06
02
2023
accepted:
23
04
2023
medline:
30
5
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
epublish
Résumé
Acute lymphoblastic leukemia is the most common childhood malignancy. Despite many advances in therapy, about 15%-20% of children with acute lymphoblastic leukemia experience a disease relapse. Isolated ocular relapse is relatively rare. A 14-year-old male with T-cell acute lymphoblastic leukemia in remission presented with sudden onset of right eye pain and visual acuity impairment. Fundoscopic examination of the eye and magnetic resonance imaging of the orbits were consistent with optic nerve infiltration. The patient was treated with salvage chemotherapy, orbital radiation and eventual bone marrow transplantation, with notable improvement in vision and regression of retinal and optic nerve findings. Optic nerve infiltration represents an ophthalmic emergency and requires urgent management. The use of radiation therapy is a helpful adjunct with systemic chemotherapy in obtaining disease remission.
Identifiants
pubmed: 37250823
doi: 10.1177/2050313X231175020
pii: 10.1177_2050313X231175020
pmc: PMC10214062
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2050313X231175020Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.
Références
Clin Ophthalmol. 2020 Oct 09;14:3153-3166
pubmed: 33116366
J Pediatr Ophthalmol Strabismus. 2017 Oct 09;54:e60-e62
pubmed: 28991353
Pediatr Int. 2015 Dec;57(6):1059-66
pubmed: 26455582
Cancer. 1989 Apr 15;63(8):1616-20
pubmed: 2635874
Cancer. 2008 Jan 15;112(2):416-32
pubmed: 18074355
N Engl J Med. 2015 Oct 15;373(16):1541-52
pubmed: 26465987
Pediatr Blood Cancer. 2021 Feb;68(2):e28684
pubmed: 32886399
JAMA Ophthalmol. 2017 Jan 12;135(1):e164656
pubmed: 28030719
Indian J Pediatr. 1999 May-Jun;66(3):470-2
pubmed: 10798098
Indian J Ophthalmol. 2021 Sep;69(9):2266-2276
pubmed: 34427197
Clin Exp Ophthalmol. 2012 Jan-Feb;40(1):e114-5
pubmed: 21668784
Am J Ophthalmol. 1988 Mar 15;105(3):294-8
pubmed: 3422790
Curr Opin Ophthalmol. 2016 Nov;27(6):545-551
pubmed: 27585213
Leukemia. 2008 Dec;22(12):2142-50
pubmed: 18818707
BMJ Case Rep. 2021 Jun 28;14(6):
pubmed: 34183317
Ophthalmology. 1983 Aug;90(8):899-905
pubmed: 6195573
Neurooncol Pract. 2017 Mar;4(1):60-66
pubmed: 31386008
Br J Haematol. 2003 Apr;121(2):280-8
pubmed: 12694250
Oman J Ophthalmol. 2010 Sep;3(3):153-4
pubmed: 21120055
Pediatr Radiol. 2000 Jan;30(1):30-2
pubmed: 10663505
Am J Ophthalmol. 2003 Jan;135(1):94-6
pubmed: 12504706
J Fr Ophtalmol. 2021 Feb;44(2):293-295
pubmed: 33097293
Cureus. 2022 Jun 3;14(6):e25625
pubmed: 35795502
Am J Ophthalmol Case Rep. 2020 Apr 10;18:100695
pubmed: 32368688
Lancet Haematol. 2016 Feb;3(2):e80-6
pubmed: 26853647
Leuk Lymphoma. 2006 Sep;47(9):1754-67
pubmed: 17064985
BMJ Case Rep. 2016 Oct 19;2016:
pubmed: 27797802
Eye (Lond). 2010 May;24(5):927-8
pubmed: 19680271
BMC Ophthalmol. 2022 Apr 27;22(1):195
pubmed: 35477372
Leuk Lymphoma. 1993 Sep;11(1-2):153-5
pubmed: 8220151