Neighborhood socioeconomic deprivation and individual-level socioeconomic status are associated with dopamine-mediated changes to monocyte subset CCR2 expression via a cAMP-dependent pathway.
Atherosclerosis
CCR2
Cardiovascular disease
Catecholamines
D2-like receptor
Dopamine
Filamin A
Neighborhood socioeconomic deprivation
Nonclassical monocytes
Social determinants of health
cAMP
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
09
05
2023
accepted:
12
05
2023
medline:
30
5
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
epublish
Résumé
Social determinants of health (SDoH) include socioeconomic, environmental, and psychological factors that impact health. Neighborhood socioeconomic deprivation (NSD) and low individual-level socioeconomic status (SES) are SDoH that associate with incident heart failure, stroke, and cardiovascular mortality, but the underlying biological mechanisms are not well understood. Previous research has demonstrated an association between NSD, in particular, and key components of the neural-hematopoietic-axis including amygdala activity as a marker of chronic stress, bone marrow activity, and arterial inflammation. Our study further characterizes the role of NSD and SES as potential sources of chronic stress related to downstream immunological factors in this stress-associated biologic pathway. We investigated how NSD, SES, and catecholamine levels (as proxy for sympathetic nervous system activation) may influence monocytes which are known to play a significant role in atherogenesis. First, in an
Identifiants
pubmed: 37251548
doi: 10.1016/j.bbih.2023.100640
pii: S2666-3546(23)00054-6
pmc: PMC10220312
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100640Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM080202
Pays : United States
Déclaration de conflit d'intérêts
None
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