Titanium complexes affect
Journal
RSC medicinal chemistry
ISSN: 2632-8682
Titre abrégé: RSC Med Chem
Pays: England
ID NLM: 101759460
Informations de publication
Date de publication:
25 May 2023
25 May 2023
Historique:
received:
13
02
2023
accepted:
01
05
2023
pmc-release:
02
05
2024
medline:
30
5
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
epublish
Résumé
Biofilms are surface or interface-associated communities of bacterial cells, embedded in a self-secreted extracellular matrix (ECM). Cells in biofilms are 100-1000 times more resistant to antibiotic treatment relative to planktonic cells due to various reasons, including the ECM acting as a diffusion barrier to antibiotic molecules, the presence of persister cells that divide slowly and are less susceptible to cell-wall targeting drugs, and the activation of efflux pumps in response to antibiotic stress. In this study we tested the effect of two titanium(iv) complexes that have been previously reported as potent and non-toxic anticancer chemotherapeutic agents on
Identifiants
pubmed: 37252093
doi: 10.1039/d3md00075c
pii: d3md00075c
pmc: PMC10211322
doi:
Types de publication
Journal Article
Langues
eng
Pagination
983-991Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There is no conflict of interest to declare.
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