Endoscopic ultrasound-guided gallbladder drainage as a first approach for jaundice palliation in unresectable malignant distal biliary obstruction: Prospective study.

EC-LAMS Hot-Spaxus drainage: EUS-GBD interventional EUS malignant biliary obstruction (MBO)

Journal

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
ISSN: 1443-1661
Titre abrégé: Dig Endosc
Pays: Australia
ID NLM: 9101419

Informations de publication

Date de publication:
30 May 2023
Historique:
received: 05 04 2023
accepted: 29 05 2023
pubmed: 30 5 2023
medline: 30 5 2023
entrez: 30 5 2023
Statut: aheadofprint

Résumé

Endoscopic retrograde cholangiopancreatography (ERCP) represents the gold standard for jaundice palliation in patients with distal malignant biliary obstruction (DMBO). Biliary drainage using electrocautery lumen apposing metal stent (EC-LAMS) is currently a well-established procedure when ERCP fails. In a palliative setting the endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) could represent an easy and valid option. We performed a prospective study with a new EC-LAMS with the primary aim to assess the clinical success rate of EUS-GBD as a first-line approach to the palliation of DMBO. In all, 37 consecutive patients undergoing EUS-GBD with a new EC-LAMS were prospectively enrolled. Clinical success was defined as bilirubin level decrease >15% within 24 h and >50% within 14 days after EC-LAMS placement. The mean age was 73.5 ± 10.8 years; there were 17 male patients (45.9%). EC-LAMS placement was technically feasible in all patients (100%) and the clinical success rate was 100%. Four patients (10.8%) experienced adverse events, one bleeding, one food impaction, and two cystic duct obstructions because of disease progression. No stent-related deaths were observed. The mean hospitalization was 7.7 ± 3.4 days. Median overall survival was 4 months (95% confidence interval 1-8). Endoscopic ultrasound-guided gallbladder drainage with the new EC-LAMS is a valid option in palliative endoscopic biliary drainage as a first-step approach in low survival patients with malignant jaundice unfit for surgery. A smaller diameter EC-LAMS should be preferred, particularly if the drainage is performed through the stomach, to avoid potential food impaction, which could result in stent dysfunction.

Identifiants

pubmed: 37253185
doi: 10.1111/den.14606
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023 Japan Gastroenterological Endoscopy Society.

Références

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Auteurs

Benedetto Mangiavillano (B)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, Varese, Italy.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Jong Ho Moon (JH)

Digestive Disease Center and Research Institute, Department of Internal Medicine, SoonChunHyang University School of Medicine, Bucheon, South Korea.

Antonio Facciorusso (A)

Gastroenterology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Jorge Vargas-Madrigal (J)

Department of Gastroenterology and Endoscopy, Hospital Enrique Baltodano Briceño, Liberia, Costa Rica.

Francesco Di Matteo (F)

Digestive Endoscopy, Campus-Bio Medico University, Rome, Italy.

Gianenrico Rizzatti (G)

Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Luca De Luca (L)

Endoscopic Unit, ASST Santi Paolo e Carlo, Milan, Italy.

Edoardo Forti (E)

Digestive and Interventional Endoscopy Unit, Niguarda Hospital, ASST Niguarda, Milan, Italy.

Massimiliano Mutignani (M)

Digestive and Interventional Endoscopy Unit, Niguarda Hospital, ASST Niguarda, Milan, Italy.

Abed Al-Lehibi (A)

King Fahad Medical City, Faculty of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Danilo Paduano (D)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, Varese, Italy.

Milutin Bulajic (M)

Digestive Endoscopy, Fatebenefratelli Isola Tiberina - Gemelli Isola, Rome, Italy.

Francesco Decembrino (F)

UOC Gastroenterologia ed Endoscopia Digestiva, Ente Ecclesiastico-Ospedale Generale Regionale "F.Miulli", Bari, Italy.

Francesco Auriemma (F)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, Varese, Italy.

Gianluca Franchellucci (G)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, Varese, Italy.
Humanitas Clinical and Research Center, IRCCS, Milan, Italy.

Alessandro De Marco (A)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, Varese, Italy.
Humanitas Clinical and Research Center, IRCCS, Milan, Italy.

Carmine Gentile (C)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, Varese, Italy.

Il Sang Shin (IS)

Digestive Disease Center and Research Institute, Department of Internal Medicine, SoonChunHyang University School of Medicine, Bucheon, South Korea.

Roberta Rea (R)

Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Marco Massidda (M)

Digestive Endoscopy, Mater Olbia Hospital, Olbia, Italy.

Federica Calabrese (F)

Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, Varese, Italy.

Vincenzo Giorgio Mirante (VG)

Gastroenterology and Digestive Endoscopy Unit, Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Andrew Ofosu (A)

Division of Digestive Diseases, University of Cincinnati, Cincinnati, USA.

Stefano Francesco Crinò (SF)

Gastroenterology and Digestive Endoscopy Unit, The Pancreas Institute, G.B. Rossi University Hospital, Verona, Italy.

Cesare Hassan (C)

Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Humanitas Clinical and Research Center, IRCCS, Milan, Italy.

Alessandro Repici (A)

Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Humanitas Clinical and Research Center, IRCCS, Milan, Italy.

Alberto Larghi (A)

Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Classifications MeSH