Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
30 05 2023
30 05 2023
Historique:
received:
04
04
2022
accepted:
10
05
2023
medline:
1
6
2023
pubmed:
31
5
2023
entrez:
30
5
2023
Statut:
epublish
Résumé
Marginalized populations experience disproportionate rates of preterm birth and early term birth. Exposure to per- and polyfluoroalkyl substances (PFAS) has been reported to reduce length of gestation, but the underlying mechanisms are unknown. In the present study, we characterized the molecular signatures of prenatal PFAS exposure and gestational age at birth outcomes in the newborn dried blood spot metabolome among 267 African American dyads in Atlanta, Georgia between 2016 and 2020. Pregnant people with higher serum perfluorooctanoic acid and perfluorohexane sulfonic acid concentrations had increased odds of an early birth. After false discovery rate correction, the effect of prenatal PFAS exposure on reduced length of gestation was associated with 8 metabolomic pathways and 52 metabolites in newborn dried blood spots, which suggested perturbed tissue neogenesis, neuroendocrine function, and redox homeostasis. These mechanisms explain how prenatal PFAS exposure gives rise to the leading cause of infant death in the United States.
Identifiants
pubmed: 37253729
doi: 10.1038/s41467-023-38710-3
pii: 10.1038/s41467-023-38710-3
pmc: PMC10229585
doi:
Substances chimiques
Fluorocarbons
0
Environmental Pollutants
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3120Subventions
Organisme : NINR NIH HHS
ID : R01 NR014800
Pays : United States
Organisme : NIEHS NIH HHS
ID : U2C ES026542
Pays : United States
Organisme : NIEHS NIH HHS
ID : P50 ES026071
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD009064
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023318
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD009746
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES032117
Pays : United States
Organisme : NIEHS NIH HHS
ID : U2C ES026560
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES019776
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES029490
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023318
Pays : United States
Informations de copyright
© 2023. The Author(s).
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