Factors associated with subclinical inflammation of wrist joints in rheumatoid arthritis patients with low or no disease activity- a RA ultrasound registry study.

Female Humans Male Middle Aged Aged Ultrasonography, Doppler Arthritis, Rheumatoid / diagnostic imaging Inflammation / diagnostic imaging Antirheumatic Agents / therapeutic use Synovitis / diagnostic imaging Wrist Joint / diagnostic imaging Registries

DAS 28 Disease activity Rheumatoid arthritis Subclinical inflammation Ultrasound

Journal

BMC musculoskeletal disorders

ISSN: 1471-2474

Titre abrégé: BMC Musculoskelet Disord

Pays: England

ID NLM: 100968565

Informations de publication

Date de publication:
30 May 2023

Historique:

received: 12 09 2022

accepted: 11 05 2023

medline: 1 6 2023

pubmed: 31 5 2023

entrez: 30 5 2023

Statut: epublish

Résumé

To evaluate the factors to predict subclinical inflammation of wrist joints in patients with RA who are in clinical remission or low disease activity. Gray scale and power Doppler ultrasound were performed on the dorsal radio-lunate of both wrists. The presence of synovitis, comorbidities, and use of disease modifying anti-rheumatic drugs were recorded. A Multivariable forward logistical regression model was used to identify factors associated with subclinical inflammation. There were 1248 patients (1010 females, 238 males; mean age: 60.0 ± 10.5 years ). 57.4% of patients in complete remission and low disease activity had sonographic inflammation. Multivariable forward logistic regression analysis indicated that male sex, smoking are positively associated with inflammation and that age, alcohol consumption, and use of methotrexate, glucocorticoid, or a biological therapy are negatively associated with inflammation. Use of biological agents decreased the risk of inflammation by 40.9%. There was evidence of subclinical inflammation in most patients who were in low or no disease activity, those with biological therapy had lower risk of subclinical inflammation.

Sections du résumé

BACKGROUND BACKGROUND

To evaluate the factors to predict subclinical inflammation of wrist joints in patients with RA who are in clinical remission or low disease activity.

METHODS METHODS

Gray scale and power Doppler ultrasound were performed on the dorsal radio-lunate of both wrists. The presence of synovitis, comorbidities, and use of disease modifying anti-rheumatic drugs were recorded. A Multivariable forward logistical regression model was used to identify factors associated with subclinical inflammation.

RESULTS RESULTS

There were 1248 patients (1010 females, 238 males; mean age: 60.0 ± 10.5 years ). 57.4% of patients in complete remission and low disease activity had sonographic inflammation. Multivariable forward logistic regression analysis indicated that male sex, smoking are positively associated with inflammation and that age, alcohol consumption, and use of methotrexate, glucocorticoid, or a biological therapy are negatively associated with inflammation. Use of biological agents decreased the risk of inflammation by 40.9%.

CONCLUSIONS CONCLUSIONS

There was evidence of subclinical inflammation in most patients who were in low or no disease activity, those with biological therapy had lower risk of subclinical inflammation.

Identifiants

DOI: 10.1186/s12891-023-06521-8 PMID: 37254118 PMC: PMC10228008

pubmed: 37254118

doi: 10.1186/s12891-023-06521-8

pii: 10.1186/s12891-023-06521-8

pmc: PMC10228008

doi:

Substances chimiques

Antirheumatic Agents 0

Types de publication

Journal Article

Langues

eng