Human embryo implantation.
Aneuploidy
Decidualisation
Implantation
Pregnancy
Uterine remodelling
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
15 05 2023
15 05 2023
Historique:
medline:
1
6
2023
pubmed:
31
5
2023
entrez:
31
5
2023
Statut:
ppublish
Résumé
Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the endometrium before the placental trophoblast invades beyond the uterine mucosa into the underlying inner myometrium. Once implanted, embryo survival pivots on the transformation of the endometrium into an anti-inflammatory placental bed, termed decidua, under homeostatic control of uterine natural killer cells. Here, we examine the evolutionary context of embryo implantation and elaborate on uterine remodelling before and after conception in humans. We also discuss the interactions between the embryo and the decidualising endometrium that regulate interstitial implantation and determine embryo fitness. Together, this Review highlights the precarious but adaptable nature of the implantation process.
Identifiants
pubmed: 37254877
pii: 310869
doi: 10.1242/dev.201507
pmc: PMC10281521
pii:
doi:
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R35 GM133747
Pays : United States
Informations de copyright
© 2023. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
Références
FASEB J. 2018 May;32(5):2467-2477
pubmed: 29259032
J Biol Chem. 2020 Apr 3;295(14):4372-4380
pubmed: 31882544
Hum Reprod. 2020 Aug 1;35(8):1797-1807
pubmed: 32644109
BMJ. 2019 Mar 20;364:l869
pubmed: 30894356
Hum Reprod. 1996 Mar;11(3):627-32
pubmed: 8671281
Mol Endocrinol. 2006 Oct;20(10):2444-55
pubmed: 16709600
Thyroid. 2008 Feb;18(2):141-4
pubmed: 18279014
Fertil Steril. 2019 Oct;112(4 Suppl1):e93-e115
pubmed: 31623748
Cell Tissue Res. 2001 Nov;306(2):335-40
pubmed: 11702245
Endocr Rev. 2014 Dec;35(6):851-905
pubmed: 25141152
Fertil Steril. 2021 Jan;115(1):45-53
pubmed: 33077239
Semin Cell Dev Biol. 2022 Nov;131:14-24
pubmed: 35094946
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5687-92
pubmed: 19297625
Endocrinology. 2001 Jul;142(7):3142-51
pubmed: 11416037
Semin Thromb Hemost. 2007 Feb;33(1):111-7
pubmed: 17253197
Am J Obstet Gynecol. 2002 Nov;187(5):1416-23
pubmed: 12439541
Nat Rev Immunol. 2023 Apr;23(4):222-235
pubmed: 36192648
Q Rev Biol. 1998 Jun;73(2):163-73
pubmed: 9618925
Nature. 2018 Nov;563(7731):347-353
pubmed: 30429548
Fertil Steril. 1996 Mar;65(3):503-9
pubmed: 8774277
Lancet. 2002 Jul 13;360(9327):151-9
pubmed: 12126838
Cell Rep. 2015 Feb 3;10(4):551-61
pubmed: 25640180
Stem Cells. 2016 Feb;34(2):346-56
pubmed: 26418742
Elife. 2022 Jun 30;11:
pubmed: 35770963
Elife. 2021 Sep 06;10:
pubmed: 34487490
Bioessays. 2012 Jan;34(1):26-35
pubmed: 22057551
Am J Med Genet A. 2016 Oct;170(10):2671-80
pubmed: 27287007
J Cell Sci. 2017 Jan 1;130(1):15-22
pubmed: 28043966
Am J Obstet Gynecol. 1979 Apr 15;133(8):859-67
pubmed: 434029
Anat Rec A Discov Mol Cell Evol Biol. 2006 Jan;288(1):84-90
pubmed: 16345078
Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):
pubmed: 35110402
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3203-8
pubmed: 16492730
J Physiol. 1974 Jan;236(2):465-72
pubmed: 16992446
Mol Biol Evol. 2021 Mar 9;38(3):1060-1074
pubmed: 33185661
Hum Reprod. 2004 Nov;19(11):2605-14
pubmed: 15465835
Endocr Rev. 2018 Oct 1;39(5):549-592
pubmed: 29905829
Nature. 2022 Mar;603(7901):497-502
pubmed: 35236989
J Clin Ultrasound. 2004 Jun;32(5):231-4
pubmed: 15124189
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9299-304
pubmed: 20439708
Hum Reprod. 1993 Feb;8(2):182-92
pubmed: 8473417
J Reprod Fertil. 1971 Jul;26(1):85-90
pubmed: 5091297
Genome Res. 2020 Jun;30(6):814-825
pubmed: 32641298
J Reprod Fertil. 1993 May;98(1):33-9
pubmed: 8345477
Hum Reprod Update. 1998 Sep-Oct;4(5):647-54
pubmed: 10027618
Sci Rep. 2015 Mar 03;5:8689
pubmed: 25732513
Hum Reprod. 2019 Apr 1;34(4):758-769
pubmed: 30838420
Nat Rev Genet. 2021 Nov;22(11):691-711
pubmed: 34354263
Free Radic Biol Med. 2000 Jan 1;28(1):64-74
pubmed: 10656292
Development. 2021 Sep 1;148(17):
pubmed: 34486650
Nat Ecol Evol. 2019 Dec;3(12):1743-1753
pubmed: 31768023
Lancet. 1995 Aug 26;346(8974):558-60
pubmed: 7658784
Reprod Biol Endocrinol. 2004 Jul 05;2:46
pubmed: 15236656
PLoS Genet. 2015 Oct 22;11(10):e1005601
pubmed: 26491874
Biol Reprod. 1975 Feb;12(1):1-40
pubmed: 806310
Endocrinology. 2011 Feb;152(2):730-40
pubmed: 21159852
EBioMedicine. 2022 Jul;81:104134
pubmed: 35779492
Endocrinology. 2014 Nov;155(11):4542-53
pubmed: 25116707
Genome Biol Evol. 2022 Dec 7;14(12):
pubmed: 36423206
Am J Anat. 1956 May;98(3):435-93
pubmed: 13362122
Endocrinology. 2006 Mar;147(3):1097-121
pubmed: 16306079
Cell Stem Cell. 2021 Sep 2;28(9):1625-1640.e6
pubmed: 34004179
J Biol Chem. 2002 Jun 7;277(23):20825-32
pubmed: 11893744
Placenta. 1981 Oct-Dec;2(4):303-16
pubmed: 7301778
Nat Rev Genet. 2006 Mar;7(3):185-99
pubmed: 16485018
Nat Med. 2011 Oct 16;17(11):1509-13
pubmed: 22001908
Am J Obstet Gynecol. 1976 Mar 15;124(6):647-52
pubmed: 816200
Rev Endocr Metab Disord. 2012 Dec;13(4):277-88
pubmed: 22865231
NPJ Digit Med. 2019 Aug 27;2:83
pubmed: 31482137
JAMA. 2015 Dec 22-29;314(24):2654-2662
pubmed: 26717030
Hum Reprod. 1993 Jan;8(1):40-5
pubmed: 8458924
Clin Chem Lab Med. 2015 Jun;53(7):1099-108
pubmed: 25720077
PLoS One. 2016 Sep 06;11(9):e0161608
pubmed: 27598793
Biol Reprod. 2018 Jul 1;99(1):196-211
pubmed: 29481584
Reprod Biol Endocrinol. 2006;4 Suppl 1:S6
pubmed: 17118170
PLoS Biol. 2019 Oct 9;17(10):e3000187
pubmed: 31596842
Genomics Proteomics Bioinformatics. 2021 Apr;19(2):208-222
pubmed: 33482359
Curr Biol. 2019 Jun 3;29(11):R455-R458
pubmed: 31163157
Trends Biotechnol. 2021 Jan;39(1):90-104
pubmed: 32654775
Development. 2017 Sep 15;144(18):3199-3210
pubmed: 28928280
Br J Obstet Gynaecol. 1995 Apr;102(4):330-1
pubmed: 7612518
Endocrinology. 1999 Oct;140(10):4809-20
pubmed: 10499541
Nat Commun. 2016 Mar 29;7:11165
pubmed: 27021558
Am J Obstet Gynecol. 2009 Jun;200(6):615.e1-6
pubmed: 19136085
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2963-8
pubmed: 12601161
Fertil Steril. 2020 May;113(5):990-995
pubmed: 32386621
Hum Reprod. 2019 Oct 2;34(10):1999-2008
pubmed: 31579915
Am Nat. 2006 Jul;168(1):114-20
pubmed: 16874618
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20596-601
pubmed: 23184984
Cell Rep. 2012 Oct 25;2(4):817-23
pubmed: 23022484
Nat Commun. 2022 Feb 17;13(1):943
pubmed: 35177608
J Assist Reprod Genet. 2018 Apr;35(4):659-667
pubmed: 29282583
J Steroid Biochem Mol Biol. 2022 Sep 9;224:106177
pubmed: 36096351
Development. 2022 Oct 15;149(20):
pubmed: 36255368
Am J Obstet Gynecol. 1973 Mar 15;115(6):759-65
pubmed: 4688578
Nature. 2022 Jan;601(7894):600-605
pubmed: 34856602
Stem Cells. 2021 Aug;39(8):1067-1080
pubmed: 33764639
Hum Reprod. 2022 Apr 1;37(4):777-792
pubmed: 35079788
Sci Immunol. 2021 Feb 19;6(56):
pubmed: 33617461
Hum Reprod. 1999 Jun;14(6):1593-8
pubmed: 10357982
Endocrinology. 2012 Mar;153(3):1063-9
pubmed: 22294752
Hum Reprod Update. 2002 Jul-Aug;8(4):333-43
pubmed: 12206468
Paediatr Perinat Epidemiol. 2020 Sep;34(5):495-503
pubmed: 32056241
Hum Reprod. 2021 Mar 18;36(4):1065-1073
pubmed: 33394013
PLoS One. 2010 Apr 21;5(4):e10258
pubmed: 20422011
Commun Biol. 2020 Jan 21;3(1):37
pubmed: 31965050
Reprod Biomed Online. 2014 Apr;28(4):409-23
pubmed: 24581986
Nat Genet. 2021 Dec;53(12):1698-1711
pubmed: 34857954
Fertil Steril. 2021 May;115(5):1212-1224
pubmed: 33685629
PLoS One. 2012;7(3):e33027
pubmed: 22427933
Fertil Steril. 2003 Mar;79(3):577-84
pubmed: 12620443
Reprod Biomed Online. 2014 Jan;28(1):14-38
pubmed: 24269084
Front Cell Dev Biol. 2021 Aug 09;9:709902
pubmed: 34434932
Endocrinology. 2018 Feb 1;159(2):994-1004
pubmed: 29244071
Nat Med. 2020 Oct;26(10):1644-1653
pubmed: 32929266
Reprod Sci. 2014 Mar;21(3):372-80
pubmed: 23885104
Nat Cell Biol. 2021 Apr;23(4):314-321
pubmed: 33837289
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5681-6
pubmed: 19307558
Integr Comp Biol. 2020 Sep 1;60(3):742-752
pubmed: 32525521
Elife. 2017 Dec 11;6:
pubmed: 29227245
J Leukoc Biol. 1997 Apr;61(4):427-35
pubmed: 9103229
Endocrinology. 2009 Jun;150(6):2882-8
pubmed: 19196802
EMBO J. 2021 May 3;40(9):e106048
pubmed: 33764576
Front Cell Dev Biol. 2021 Jan 18;8:621016
pubmed: 33537312
N Engl J Med. 2015 Nov 19;373(21):2089-90
pubmed: 26581010
J Anat. 1984 Sep;139 ( Pt 2):239-52
pubmed: 6490516
Evol Anthropol. 2013 Sep-Oct;22(5):226-38
pubmed: 24166923
Trends Cell Biol. 2017 Jan;27(1):55-68
pubmed: 27773484
Cell. 2012 Jul 6;150(1):7-9
pubmed: 22770210
Biol Reprod. 2014 Oct;91(4):98
pubmed: 25187529
BJOG. 2010 Sep;117(10):1175-85
pubmed: 20560946
Nat Genet. 2011 Sep 25;43(11):1154-9
pubmed: 21946353
Nature. 1998 Oct 15;395(6703):707-10
pubmed: 9790192
Hum Reprod. 2009 Jun;24(6):1393-401
pubmed: 19252193
Angiogenesis. 1998;2(4):287-94
pubmed: 14517449
Endocrinology. 2019 Oct 1;160(10):2282-2297
pubmed: 31290979
BJOG. 2004 Sep;111(9):944-9
pubmed: 15327609
Cell. 2020 Sep 3;182(5):1125-1139.e18
pubmed: 32822574
Immunology. 2001 Apr;102(4):434-40
pubmed: 11328377
Nat Med. 2012 Jul;18(7):1112-7
pubmed: 22729284
Mol Hum Reprod. 2018 Jul 1;24(7):375-387
pubmed: 29846687
Gynecol Obstet Invest. 1985;20(3):113-29
pubmed: 4085915
J Mol Endocrinol. 2018 Jul;61(1):R25-R41
pubmed: 29789322
Gynecol Obstet Invest. 1984;18(4):174-7
pubmed: 6096230
Science. 2019 Sep 27;365(6460):1466-1469
pubmed: 31604276
Q Rev Biol. 1993 Dec;68(4):495-532
pubmed: 8115596
Sci Rep. 2014 Feb 06;4:3894
pubmed: 24503642
FASEB J. 2021 Apr;35(4):e21336
pubmed: 33749894
Hum Reprod Update. 2019 Mar 1;25(2):202-223
pubmed: 30624659
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6566-E6575
pubmed: 28747528
Hum Reprod Update. 1998 Sep-Oct;4(5):496-502
pubmed: 10027601
Sci Adv. 2022 Aug 12;8(32):eabj3725
pubmed: 35947672
Cell Discov. 2021 Jan 4;7(1):1
pubmed: 33390590
J Reprod Fertil. 1981 Jan;61(1):235-40
pubmed: 7452622
Nat Rev Mol Cell Biol. 2022 Apr;23(4):250-265
pubmed: 34987171
Cell. 2012 Jul 6;150(1):29-38
pubmed: 22770213
Front Cell Dev Biol. 2022 Jul 22;10:919731
pubmed: 35938159
Reprod Sci. 2009 Feb;16(2):147-51
pubmed: 19001552
Philos Trans R Soc Lond B Biol Sci. 2015 Mar 5;370(1663):20140070
pubmed: 25602074
Oxf Open Immunol. 2020 Dec 14;2(1):iqaa006
pubmed: 36845570
Hum Reprod. 1994 Apr;9(4):629-37
pubmed: 8046014
Curr Genomics. 2011 Aug;12(5):371-8
pubmed: 22294879
Nature. 2022 Jul;607(7918):249-255
pubmed: 35831602
PLoS Biol. 2019 Sep 12;17(9):e3000421
pubmed: 31513564
Am J Obstet Gynecol. 2017 Nov;217(5):546-555
pubmed: 28578177
Mol Hum Reprod. 1999 Oct;5(10):961-5
pubmed: 10508225
Hum Reprod. 2002 May;17(5):1399-403
pubmed: 11980771
Wiley Interdiscip Rev Dev Biol. 2018 May;7(3):e310
pubmed: 29350886
J Clin Endocrinol Metab. 1991 Dec;73(6):1352-9
pubmed: 1720127
Front Reprod Health. 2022 Jan 20;3:811537
pubmed: 36304009
Sci Adv. 2019 Jun 05;5(6):eaaw0341
pubmed: 31183404
F1000Res. 2016 Nov 25;5:2765
pubmed: 28580126
N Engl J Med. 2001 Nov 8;345(19):1400-8
pubmed: 11794174
Immunity. 2023 Mar 14;56(3):606-619.e7
pubmed: 36750100
PLoS One. 2012;7(12):e52252
pubmed: 23300625
J Reprod Immunol. 2020 Feb;137:102626
pubmed: 31783286
Nat Immunol. 2008 May;9(5):503-10
pubmed: 18425107
Fertil Steril. 1995 Aug;64(2):237-51
pubmed: 7615097
FASEB J. 2010 May;24(5):1541-51
pubmed: 20026682
Sci Rep. 2022 May 21;12(1):8624
pubmed: 35597810
Mol Hum Reprod. 2022 Nov 30;28(12):
pubmed: 36370081
Nat Commun. 2020 Aug 10;11(1):3987
pubmed: 32778678
Hum Reprod Update. 2014 Jul-Aug;20(4):517-29
pubmed: 24591147
Nat Commun. 2020 Jan 20;11(1):381
pubmed: 31959757
Am J Reprod Immunol. 2022 Jan;87(1):e13423
pubmed: 33764560
Nat Rev Mol Cell Biol. 2014 Jul;15(7):482-96
pubmed: 24954210
Biol Reprod. 2020 May 26;102(6):1160-1169
pubmed: 32129461
N Engl J Med. 1999 Jun 10;340(23):1796-9
pubmed: 10362823
Nature. 2020 Apr;580(7805):640-646
pubmed: 32350471
Virchows Arch A Pathol Anat Histopathol. 1989;414(2):105-12
pubmed: 2492689
Am J Obstet Gynecol. 2020 Nov;223(5):624-664
pubmed: 32707266
PLoS One. 2012;7(7):e41424
pubmed: 22848492
Best Pract Res Clin Obstet Gynaecol. 2004 Apr;18(2):265-83
pubmed: 15157642
Elife. 2021 Oct 08;10:
pubmed: 34623259
Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):
pubmed: 35169075
Hum Reprod Update. 2015 May-Jun;21(3):340-52
pubmed: 25667189
PLoS Biol. 2018 Aug 24;16(8):e2005594
pubmed: 30142145
Biol Reprod. 2003 Feb;68(2):337-57
pubmed: 12533395
Nat Commun. 2020 Jun 11;11(1):2958
pubmed: 32528010
Q Rev Biol. 1983 Dec;58(4):513-38
pubmed: 6686686