Influenza Defective Interfering Virus Promotes Multiciliated Cell Differentiation and Reduces the Inflammatory Response in Mice.
influenza
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
29 06 2023
29 06 2023
Historique:
medline:
3
7
2023
pubmed:
31
5
2023
entrez:
31
5
2023
Statut:
ppublish
Résumé
Influenza defective interfering (DI) viruses have long been considered promising antiviral candidates because of their ability to interfere with replication-competent viruses and induce antiviral immunity. However, the mechanisms underlying DI-mediated antiviral immunity have not been extensively explored. Here, we demonstrated the interferon (IFN)-independent protection conferred by the influenza DI virus against homologous virus infection in mice deficient in type I and III IFN signaling. We identified unique host signatures responding to DI coinfection by integrating transcriptional and posttranscriptional regulatory data. DI-treated mice exhibited reduced viral transcription, less intense inflammatory and innate immune responses, and primed multiciliated cell differentiation in their lungs at an early stage of infection, even in the absence of type I or III IFNs. This increased multiciliogenesis could also be detected at the protein level via the immunofluorescence staining of lung tissue from DI-treated mice. Overall, our study provides mechanistic insight into the protection mediated by DIs, implying a unifying theme involving inflammation and multiciliogenesis in maintaining respiratory homeostasis and revealing their IFN-independent antiviral activity.
Identifiants
pubmed: 37255439
doi: 10.1128/jvi.00493-23
pmc: PMC10308934
doi:
Substances chimiques
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0049323Subventions
Organisme : NIAID NIH HHS
ID : 75N93021C00016
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140766
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI124141
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Elife. 2018 Apr 13;7:
pubmed: 29651984
Clin Exp Immunol. 2018 Sep;193(3):376-385
pubmed: 29892977
PLoS Pathog. 2017 Oct 12;13(10):e1006650
pubmed: 29023600
Annu Rev Virol. 2019 Sep 29;6(1):567-584
pubmed: 31283436
J Interferon Cytokine Res. 2015 Jul;35(7):554-62
pubmed: 25756191
Acta Virol. 1964 Jan;8:59-67
pubmed: 14106023
Curr Opin Virol. 2011 Dec;1(6):519-25
pubmed: 22328912
Rev Med Virol. 2010 Jan;20(1):51-62
pubmed: 20041441
Vaccine. 2013 Nov 19;31(48):5713-21
pubmed: 24099876
Future Virol. 2018 Jul;13(7):493-503
pubmed: 30245734
J Virol. 2007 Nov;81(22):12227-37
pubmed: 17804509
Dev Dyn. 2011 Jun;240(6):1512-7
pubmed: 21438071
mBio. 2015 Oct 06;6(5):e01265-15
pubmed: 26443454
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
PLoS Pathog. 2015 Sep 03;11(9):e1005122
pubmed: 26336095
J Med Microbiol. 2014 Sep;63(Pt 9):1131-1142
pubmed: 24913561
Development. 2016 Dec 15;143(24):4654-4664
pubmed: 27864379
J Intern Med. 2013 Sep;274(3):215-26
pubmed: 23772809
Nat Commun. 2014 Jul 22;5:4418
pubmed: 25048963
Nat Cell Biol. 2011 Jun;13(6):693-9
pubmed: 21602795
Nat Cell Biol. 2013 Dec;15(12):1434-44
pubmed: 24240477
Genes Dev. 2014 Jul 1;28(13):1461-71
pubmed: 24934224
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Sci Immunol. 2017 Oct 6;2(16):
pubmed: 28986419
Nucleic Acids Res. 2012 May;40(10):4288-97
pubmed: 22287627
Sci Rep. 2018 Aug 17;8(1):12369
pubmed: 30120325
Nature. 1970 Apr 25;226(5243):325-7
pubmed: 5439728
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
J Proteome Res. 2020 Nov 6;19(11):4486-4495
pubmed: 32981324
J Infect Dis. 1979 Sep;140(3):305-15
pubmed: 227968
Nat Immunol. 2015 Aug;16(8):802-9
pubmed: 26194286
Nucleic Acids Res. 2013 May 1;41(10):e108
pubmed: 23558742
Acta Neuropathol. 1976 Mar 15;34(2):157-69
pubmed: 1258610
J Virol. 2009 Oct;83(19):10309-13
pubmed: 19605485
J Gen Virol. 2011 Sep;92(Pt 9):2122-2132
pubmed: 21632569
Nat Cell Biol. 2012 Jan 08;14(2):140-7
pubmed: 22231168
mBio. 2020 Jan 14;11(1):
pubmed: 31937643
Curr Protoc Chem Biol. 2013;5(1):1-23
pubmed: 23788322
Immunity. 2017 May 16;46(5):875-890.e6
pubmed: 28514692
Science. 1943 Jul 23;98(2534):87-9
pubmed: 17749157
J Virol. 2013 Jul;87(14):8064-74
pubmed: 23678180
PLoS Pathog. 2013;9(11):e1003773
pubmed: 24278020
Virology. 1979 May;95(1):48-58
pubmed: 442544
Epigenomics. 2018 Jun;10(6):829-844
pubmed: 29888954
Cell. 1981 Oct;26(2 Pt 2):145-54
pubmed: 7037195
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
J Leukoc Biol. 2018 Sep;104(3):515-524
pubmed: 29969525
J Virol. 2014 May;88(10):5217-27
pubmed: 24574404
Vaccine. 2011 Sep 2;29(38):6584-91
pubmed: 21762748
Trends Immunol. 2018 Oct;39(10):848-858
pubmed: 30219309
Virus Res. 2011 Sep;160(1-2):360-6
pubmed: 21816185
Annu Rev Virol. 2019 Sep 29;6(1):547-566
pubmed: 31082310
J Gen Microbiol. 1959 Dec;21:498-509
pubmed: 13798559
Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26926-26935
pubmed: 33046650
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Virol. 2008 Sep;82(17):8570-8
pubmed: 18579602
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
J Gen Virol. 2011 Dec;92(Pt 12):2879-2888
pubmed: 21880840
PLoS Pathog. 2013 Oct;9(10):e1003703
pubmed: 24204261
Adv Virus Res. 1954;2:59-79
pubmed: 13228257
BMC Microbiol. 2014 Sep 30;14:252
pubmed: 25266911
Vaccine. 2011 Mar 24;29(15):2777-84
pubmed: 21320545
J Virol. 2010 Nov;84(21):11515-22
pubmed: 20739515
Genome Biol. 2017 Nov 15;18(1):220
pubmed: 29141660
Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16303-8
pubmed: 20805493
Nat Rev Immunol. 2014 May;14(5):315-28
pubmed: 24762827
J Immunol. 1952 Aug;69(2):155-81
pubmed: 14946411
Annu Rev Immunol. 2014;32:513-45
pubmed: 24555472
J Biol Chem. 2017 May 5;292(18):7295-7303
pubmed: 28289095
Nat Microbiol. 2019 Jul;4(7):1075-1087
pubmed: 31160826