Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin.
Schwann cell
Wnt1-Cre
fibroblast
integrin α6
melanocyte
neural crest
skin
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
09
01
2023
accepted:
02
05
2023
medline:
31
5
2023
pubmed:
31
5
2023
entrez:
31
5
2023
Statut:
epublish
Résumé
Neural crest-derived cells play essential roles in skin function and homeostasis. However, how they interact with environmental cues and differentiate into functional skin cells remains unclear. Using a combination of single-cell data analysis, neural crest lineage tracing, and flow cytometry, we found that the expression of integrin α6 (ITGA6) in neural crest and its derivatives was developmentally regulated and that ITGA6 could serve as a functional surface marker for distinguishing neural crest derivatives in the skin. Based on the expression of ITGA6, Wnt1-Cre lineage neural crest derivatives in the skin could be categorized into three subpopulations, namely, ITGA6
Identifiants
pubmed: 37255601
doi: 10.3389/fcell.2023.1140554
pii: 1140554
pmc: PMC10225710
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1140554Informations de copyright
Copyright © 2023 Ma, Li, Cao, Zhan, Fu, Xiao and Yang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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