White matter and neurochemical mechanisms underlying age-related differences in motor processing speed.
Cognitive neuroscience
Neuroscience
Physics magnetic resonance imaging
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
received:
17
08
2022
revised:
11
01
2023
accepted:
27
04
2023
medline:
31
5
2023
pubmed:
31
5
2023
entrez:
31
5
2023
Statut:
epublish
Résumé
Aging is associated with changes in the central nervous system and leads to reduced life quality. Here, we investigated the age-related differences in the CNS underlying motor performance deficits using magnetic resonance spectroscopy and diffusion MRI. MRS measured N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr) concentrations in the sensorimotor and occipital cortex, whereas dMRI quantified apparent fiber density (FD) in the same voxels to evaluate white matter microstructural organization. We found that aging was associated with increased reaction time and reduced FD and NAA concentration in the sensorimotor voxel. Both FD and NAA mediated the association between age and reaction time. The NAA concentration was found to mediate the association between age and FD in the sensorimotor voxel. We propose that the age-related decrease in NAA concentration may result in reduced axonal fiber density in the sensorimotor cortex which may ultimately account for the response slowness of older participants.
Identifiants
pubmed: 37255665
doi: 10.1016/j.isci.2023.106794
pii: S2589-0042(23)00871-4
pmc: PMC10225899
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106794Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors have no conflict of interest or competing interests to disclose.
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