Evaluation of curcumin effect on Il6, Sirt1, TNFα and NFkB expression of liver tissues in diabetic mice with STZ.
Curcumin
Diabetes
IL6
NF- kB
Real Time-PCR
Sirt1
TNF-α
Journal
Journal of diabetes and metabolic disorders
ISSN: 2251-6581
Titre abrégé: J Diabetes Metab Disord
Pays: Switzerland
ID NLM: 101590741
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
15
02
2022
revised:
15
02
2022
accepted:
05
07
2022
medline:
31
5
2023
pubmed:
31
5
2023
entrez:
31
5
2023
Statut:
epublish
Résumé
Curcumin is active ingredient of turmeric The main purpose of this study is evaluating impact of curcumin on suger, hypoalgesia and inflammatory factors in diabetic mice. Male mice divided into six groups of 6. One group as a negative and the other five groups injected with Streptozotocin (STZ) (200 mg/kg). Diabetic mice in each group given different treatments for twenty-one days.After that, blood sugar and neuroathy studies have been done and tissue samples the liver were studied for gene expression. Curcumin reduced blood sugar, but the rate of hypoglycemia was significantly lower than metformin group P > 0.05, and the comparison of the synergistic effect of curcumin and metformin with metformin was not significant P > 0.05. Also, in neuropathy studies, the groups which recieved curcumin and metformin have shown a significant difference with diabetic group P < 0.01, Also, by evaluating inflammatory factors, there was a significant difference in the expression of TNF-a, IL-6 and NfkB, but there is no significant difference in the expression of Sirt1 P < 0.05. The analgesic effect of curcumin was quite evident, probably due to the significant impact of this herbal drug in reducing the expression of inflammatory genes NF-kB, IL6, and TNF-α. The online version contains supplementary material available at 10.1007/s40200-022-01090-4.
Sections du résumé
Background
UNASSIGNED
Curcumin is active ingredient of turmeric The main purpose of this study is evaluating impact of curcumin on suger, hypoalgesia and inflammatory factors in diabetic mice.
Materials and methods
UNASSIGNED
Male mice divided into six groups of 6. One group as a negative and the other five groups injected with Streptozotocin (STZ) (200 mg/kg). Diabetic mice in each group given different treatments for twenty-one days.After that, blood sugar and neuroathy studies have been done and tissue samples the liver were studied for gene expression.
Result
UNASSIGNED
Curcumin reduced blood sugar, but the rate of hypoglycemia was significantly lower than metformin group P > 0.05, and the comparison of the synergistic effect of curcumin and metformin with metformin was not significant P > 0.05. Also, in neuropathy studies, the groups which recieved curcumin and metformin have shown a significant difference with diabetic group P < 0.01, Also, by evaluating inflammatory factors, there was a significant difference in the expression of TNF-a, IL-6 and NfkB, but there is no significant difference in the expression of Sirt1 P < 0.05.
Conclusions
UNASSIGNED
The analgesic effect of curcumin was quite evident, probably due to the significant impact of this herbal drug in reducing the expression of inflammatory genes NF-kB, IL6, and TNF-α.
Supplementary Information
UNASSIGNED
The online version contains supplementary material available at 10.1007/s40200-022-01090-4.
Identifiants
pubmed: 37255806
doi: 10.1007/s40200-022-01090-4
pii: 1090
pmc: PMC10225420
doi:
Types de publication
Journal Article
Langues
eng
Pagination
205-215Informations de copyright
© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2022, corrected publication 2022.
Déclaration de conflit d'intérêts
Conflict of interestThere is not any conflict of interest between authors in all steps of article preparation and project’s performance.
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