Autophagy in peritoneal fibrosis.
autophagy
human peritoneal mesothelial cells
peritoneal dialysis
peritoneal dialysis-related peritonitis
peritoneal fibrosis
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
03
2023
accepted:
03
05
2023
medline:
31
5
2023
pubmed:
31
5
2023
entrez:
31
5
2023
Statut:
epublish
Résumé
Peritoneal dialysis (PD) is a widely accepted renal replacement therapy for patients with end-stage renal disease (ESRD). Morphological and functional changes occur in the peritoneal membranes (PMs) of patients undergoing long-term PD. Peritoneal fibrosis (PF) is a common PD-related complication that ultimately leads to PM injury and peritoneal ultrafiltration failure. Autophagy is a cellular process of "self-eating" wherein damaged organelles, protein aggregates, and pathogenic microbes are degraded to maintain intracellular environment homeostasis and cell survival. Growing evidence shows that autophagy is involved in fibrosis progression, including renal fibrosis and hepatic fibrosis, in various organs. Multiple risk factors, including high-glucose peritoneal dialysis solution (HGPDS), stimulate the activation of autophagy, which participates in PF progression, in human peritoneal mesothelial cells (HPMCs). Nevertheless, the underlying roles and mechanisms of autophagy in PF progression remain unclear. In this review, we discuss the key roles and potential mechanisms of autophagy in PF to offer novel perspectives on future therapy strategies for PF and their limitations.
Identifiants
pubmed: 37256065
doi: 10.3389/fphys.2023.1187207
pii: 1187207
pmc: PMC10226653
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1187207Informations de copyright
Copyright © 2023 Su, Yang, Zou, An, Chen, Yang, Yang, Yao and Liu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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