Saponin protects against cyclophosphamide-induced kidney and liver damage via antioxidant and anti-inflammatory actions.
antioxidants
cyclophosphamide
inflammation
kidney
liver
saponin
Journal
Physiology international
ISSN: 2498-602X
Titre abrégé: Physiol Int
Pays: Hungary
ID NLM: 101696724
Informations de publication
Date de publication:
12 Jun 2023
12 Jun 2023
Historique:
received:
22
01
2023
revised:
30
04
2023
accepted:
05
05
2023
medline:
14
6
2023
pubmed:
31
5
2023
entrez:
31
5
2023
Statut:
epublish
Résumé
The liver and kidney are organs affected by chemotherapy drugs such as cyclophosphamide (CP). This study examined the protective effects of treatment with saponin (SP) against CP-induced nephrotoxicity and hepatotoxicity. 24 adult male mice were divided into four groups (N = 6): Control group, CP (15 mg kg-1), SP (2.5 mg kg-1) and CP + SP. After treatment, blood samples were collected for the determination of biochemical parameters. Liver and kidney samples were taken for histological analysis and assessment of oxidative stress and inflammatory markers. Cyclophosphamide decreased renal and liver functions and antioxidant enzymes, which significantly increased blood urea nitrogen and creatinine (BUN, Cr), liver enzyme levels, malondialdehyde, nuclear factor kappa β (NF-kB) and Interleukin 1 beta (IL-1B) concentrations. Moreover, histopathological findings of the CP group showed that there were acute tubular necrosis and glomerular atrophy in the renal tissues and lymphocyte infiltration in the liver samples. Treatment with saponin improved hepatic and renal functions, pathological changes and antioxidant capacity, and also decreased lipid peroxidation and inflammation. It seems that saponin could exert a hepato-nephroprotective effect against cyclophosphamide toxicity.
Sections du résumé
Background
UNASSIGNED
The liver and kidney are organs affected by chemotherapy drugs such as cyclophosphamide (CP). This study examined the protective effects of treatment with saponin (SP) against CP-induced nephrotoxicity and hepatotoxicity.
Methods
UNASSIGNED
24 adult male mice were divided into four groups (N = 6): Control group, CP (15 mg kg-1), SP (2.5 mg kg-1) and CP + SP. After treatment, blood samples were collected for the determination of biochemical parameters. Liver and kidney samples were taken for histological analysis and assessment of oxidative stress and inflammatory markers.
Results
UNASSIGNED
Cyclophosphamide decreased renal and liver functions and antioxidant enzymes, which significantly increased blood urea nitrogen and creatinine (BUN, Cr), liver enzyme levels, malondialdehyde, nuclear factor kappa β (NF-kB) and Interleukin 1 beta (IL-1B) concentrations. Moreover, histopathological findings of the CP group showed that there were acute tubular necrosis and glomerular atrophy in the renal tissues and lymphocyte infiltration in the liver samples. Treatment with saponin improved hepatic and renal functions, pathological changes and antioxidant capacity, and also decreased lipid peroxidation and inflammation.
Conclusion
UNASSIGNED
It seems that saponin could exert a hepato-nephroprotective effect against cyclophosphamide toxicity.
Identifiants
pubmed: 37256739
doi: 10.1556/2060.2023.00190
doi:
Substances chimiques
Antioxidants
0
Cyclophosphamide
8N3DW7272P
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM