Ameliorating effects of cystine and theanine in a cancer cachexia mouse model.

Humans Cachexia / drug therapy Cystine / pharmacology Neoplasms / complications Weight Loss
Anamorelin Cancer cachexia Cystine and theanine

Journal

Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 09 11 2022
revised: 18 03 2023
accepted: 20 04 2023
medline: 2 6 2023
pubmed: 1 6 2023
entrez: 31 5 2023
Statut: ppublish

Résumé

Cachexia is a common cancer complication and is associated with weight loss and anorexia. In this study, we investigated the ameliorating effects of cystine and theanine on cancer cachexia using a mouse model. In mice carrying the colon cancer cell line C-26, there was a suppression of body weight increase and reduction in both internal fat and lower limb muscles. Repeated cystine and theanine administration significantly prevented weight loss, internal fat loss, lower limb muscle loss, and serum IL-6 increase in the cachexia model. These results suggested that cystine and theanine may be effective in ameliorating cancer cachexia.

Identifiants

DOI: 10.1016/j.jphs.2023.04.008 PMID: 37257943
pubmed: 37257943
pii: S1347-8613(23)00029-4
doi: 10.1016/j.jphs.2023.04.008
pii:
doi:

Substances chimiques

theanine 8021PR16QO
Cystine 48TCX9A1VT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

163-166

Informations de copyright

Copyright © 2023 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflicts of interest.

Auteurs

Hibiki Kudamatsu (H)

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Takehiro Kawashiri (T)

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Electronic address: kawashiri.takehiro.650@m.kyushu-u.ac.jp.

Keisuke Mine (K)

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan; Department of Glocal Healthcare Science, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Kohei Mori (K)

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Mizuki Inoue (M)

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Haruna Ishida (H)

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Mayako Uchida (M)

Department of Education and Research Center for Pharmacy Practice, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, 97-1, Kodominamihokotate, Kyotanabe-shi, Kyoto, 610-0395 Japan.

Takashi Tsuchiya (T)

Department of Surgery, Sendai City Medical Center, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan.

Daisuke Kobayashi (D)

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Takao Shimazoe (T)

Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ameliorating effects of cystine and theanine...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Cachexie › Ameliorating effects of cystine and theanine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Cystine › Ameliorating effects of cystine and theanine...
questionsmedicales.fr › Tumeurs › Ameliorating effects of cystine and theanine...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Perte de poids › Ameliorating effects of cystine and theanine...