Neuro-immune interactions and immuno-oncology.
cancer
immunology
immunotherapy
neuroimmunology
neuroscience
oncology
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
01
03
2023
revised:
24
04
2023
accepted:
08
05
2023
pmc-release:
01
08
2024
medline:
21
7
2023
pubmed:
1
6
2023
entrez:
31
5
2023
Statut:
ppublish
Résumé
The nervous system is an important component of the tumor microenvironment (TME), driving tumorigenesis and tumor progression. Neuronal cues (e.g., neurotransmitters and neuropeptides) in the TME cause phenotypic changes in immune cells, such as increased exhaustion and inhibition of effector cells, which promote immune evasion and cancer progression. Two types of immune regulation by tumor-associated nerves are discussed in this review: regulation via neuronal stimuli (i.e., by neural transmission) and checkpoint-mediated neuronal immune regulation. The latter occurs via the expression of immune checkpoints on the membranes of intratumoral nerves and glial cells. Here, we summarize novel findings regarding the neuroimmune circuits in the tumor milieu, while emphasizing the potential targets of new and affordable anticancer therapeutic approaches.
Identifiants
pubmed: 37258398
pii: S2405-8033(23)00085-7
doi: 10.1016/j.trecan.2023.05.002
pmc: PMC10524972
mid: NIHMS1905401
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
636-649Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE032018
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA242006
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests None are declared by the authors.
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