Nutrient sensors and their crosstalk.
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
31
10
2022
accepted:
13
03
2023
revised:
22
02
2023
medline:
5
7
2023
pubmed:
1
6
2023
entrez:
31
5
2023
Statut:
ppublish
Résumé
The macronutrients glucose, lipids, and amino acids are the major components that maintain life. The ability of cells to sense and respond to fluctuations in these nutrients is a crucial feature for survival. Nutrient-sensing pathways are thus developed to govern cellular energy and metabolic homeostasis and regulate diverse biological processes. Accordingly, perturbations in these sensing pathways are associated with a wide variety of pathologies, especially metabolic diseases. Molecular sensors are the core within these sensing pathways and have a certain degree of specificity and affinity to sense the intracellular fluctuation of each nutrient either by directly binding to that nutrient or indirectly binding to its surrogate molecules. Once the changes in nutrient levels are detected, sensors trigger signaling cascades to fine-tune cellular processes for energy and metabolic homeostasis, for example, by controlling uptake, de novo synthesis or catabolism of that nutrient. In this review, we summarize the major discoveries on nutrient-sensing pathways and explain how those sensors associated with each pathway respond to intracellular nutrient availability and how these mechanisms control metabolic processes. Later, we further discuss the crosstalk between these sensing pathways for each nutrient, which are intertwined to regulate overall intracellular nutrient/metabolic homeostasis.
Identifiants
pubmed: 37258576
doi: 10.1038/s12276-023-01006-z
pii: 10.1038/s12276-023-01006-z
pmc: PMC10318010
doi:
Substances chimiques
Amino Acids
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1076-1089Informations de copyright
© 2023. The Author(s).
Références
Nature. 2017 Aug 3;548(7665):112-116
pubmed: 28723898
Biomedicines. 2021 Jul 26;9(8):
pubmed: 34440098
Diabet Med. 2009 Mar;26(3):197-210
pubmed: 19317813
Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E466-71
pubmed: 11500301
J Clin Invest. 1995 Nov;96(5):2489-95
pubmed: 7593639
Nat Rev Mol Cell Biol. 2020 Apr;21(4):225-245
pubmed: 31848472
Cell. 2017 Oct 19;171(3):642-654.e12
pubmed: 29053970
Annu Rev Nutr. 1993;13:463-96
pubmed: 8369155
J Biol Chem. 2010 Dec 24;285(52):40409-15
pubmed: 20956526
Wiley Interdiscip Rev Syst Biol Med. 2011 Sep-Oct;3(5):562-87
pubmed: 21755605
Science. 2013 May 31;340(6136):1100-6
pubmed: 23723238
Cell Metab. 2016 Apr 12;23(4):580-9
pubmed: 27076075
Anal Chem. 2016 Dec 6;88(23):11271-11282
pubmed: 27779381
J Biol Chem. 1997 Jul 25;272(30):18572-9
pubmed: 9228023
FEBS Lett. 2000 Mar 31;470(3):300-4
pubmed: 10745085
J Clin Invest. 1977 Jul;60(1):265-70
pubmed: 874089
Int J Mol Sci. 2021 Aug 02;22(15):
pubmed: 34361064
Science. 2016 Jan 1;351(6268):53-8
pubmed: 26586190
Cell Discov. 2016 Dec 27;2:16051
pubmed: 28066558
Nat Rev Drug Discov. 2019 Aug;18(8):629-650
pubmed: 31073243
Nature. 2016 Aug 11;536(7615):229-33
pubmed: 27487210
Mol Cell. 2003 Jan;11(1):25-33
pubmed: 12535518
Biochem Soc Trans. 2013 Aug;41(4):902-5
pubmed: 23863153
Nat Chem Biol. 2016 Jan;12(1):15-21
pubmed: 26571352
Mol Cell Biochem. 2019 May;455(1-2):169-183
pubmed: 30511343
Cell Prolif. 2020 Nov;53(11):e12891
pubmed: 33030764
Mol Cell. 2005 Sep 16;19(6):829-40
pubmed: 16168377
J Biol Chem. 1997 Aug 8;272(32):20213-21
pubmed: 9242699
Curr Top Cell Regul. 1983;22:143-76
pubmed: 6135568
Nat Cell Biol. 2008 Aug;10(8):935-45
pubmed: 18604198
Nature. 2011 Nov 20;481(7381):380-4
pubmed: 22101433
J Nutr. 2006 Jun;136(6 Suppl):1666S-1669S
pubmed: 16702337
Cell. 2012 Apr 13;149(2):410-24
pubmed: 22424946
Diagnostics (Basel). 2020 Jun 10;10(6):
pubmed: 32532018
Science. 2015 Jan 9;347(6218):188-94
pubmed: 25567906
PLoS One. 2017 Feb 9;12(2):e0171587
pubmed: 28182770
ACS Pharmacol Transl Sci. 2018 Apr 24;1(1):21-31
pubmed: 32219202
Annu Rev Biochem. 2018 Jun 20;87:783-807
pubmed: 28841344
Cell Metab. 2020 Feb 4;31(2):267-283.e12
pubmed: 31866442
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):
pubmed: 34074763
J Biol Chem. 1993 Dec 5;268(34):25836-45
pubmed: 7902355
Redox Biol. 2020 Jan;29:101376
pubmed: 31926616
J Biol Chem. 2008 Mar 7;283(10):6050-7
pubmed: 18174169
J Biol Chem. 2018 Oct 19;293(42):16390-16401
pubmed: 30194281
FEMS Microbiol Rev. 2014 Mar;38(2):254-99
pubmed: 24483210
Biochim Biophys Acta. 2016 Oct;1861(10):1461-71
pubmed: 27090938
Diabetes. 2001 Jul;50(7):1580-7
pubmed: 11423479
Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118889
pubmed: 33091505
Nutrients. 2021 Jul 28;13(8):
pubmed: 34444752
Parasitol Res. 2020 Jan;119(1):203-214
pubmed: 31845020
Nature. 2017 Mar 16;543(7645):438-442
pubmed: 28199306
Cell Metab. 2013 Aug 6;18(2):153-61
pubmed: 23791484
J Biol Chem. 2001 Feb 23;276(8):6030-6
pubmed: 11096076
Nat Chem Biol. 2012 Apr 15;8(6):547-54
pubmed: 22504299
Nat Genet. 1997 Nov;17(3):324-6
pubmed: 9354798
Cell Res. 2008 Jun;18(6):609-21
pubmed: 18504457
Mol Cell. 2002 Aug;10(2):237-45
pubmed: 12191470
Biochem Biophys Res Commun. 2017 Nov 18;493(2):1129-1135
pubmed: 28882589
Matrix Biol. 2021 Jun;100-101:65-83
pubmed: 33429026
Annu Rev Biomed Eng. 2017 Jun 21;19:163-194
pubmed: 28301735
Cancer Cell Int. 2021 Nov 16;21(1):606
pubmed: 34784907
Diabetologia. 2009 Jan;52(1):154-9
pubmed: 18974968
Nat Metab. 2022 Aug;4(8):1022-1040
pubmed: 35995997
Biochemistry. 2014 Dec 16;53(49):7846-53
pubmed: 25453233
Cell Metab. 2018 Feb 6;27(2):299-313
pubmed: 29153408
Mol Cell. 1999 Mar;3(3):397-403
pubmed: 10198642
Mol Cell. 2013 Feb 7;49(3):379-87
pubmed: 23395268
Cell Rep. 2016 Aug 9;16(6):1510-1517
pubmed: 27477288
Mol Cell. 2012 Apr 13;46(1):105-10
pubmed: 22424774
Front Cell Dev Biol. 2021 Apr 01;9:646482
pubmed: 33869199
Cancer Lett. 2018 Aug 28;430:133-147
pubmed: 29777783
Nat Commun. 2022 May 25;13(1):2904
pubmed: 35614056
Mol Cell. 2004 Jul 23;15(2):259-68
pubmed: 15260976
EMBO J. 2002 Mar 1;21(5):930-41
pubmed: 11867521
J Agric Food Chem. 2020 Apr 29;68(17):4876-4883
pubmed: 32293174
J Biol Chem. 1998 Mar 6;273(10):5785-93
pubmed: 9488713
J Biol Chem. 2020 Mar 6;295(10):2890-2899
pubmed: 32019866
EMBO J. 2021 Nov 2;40(21):e108028
pubmed: 34472622
Prog Lipid Res. 2021 Jan;81:101071
pubmed: 33186641
Annu Rev Biochem. 2021 Jun 20;90:659-679
pubmed: 34153214
Science. 2008 Jun 13;320(5882):1496-501
pubmed: 18497260
Dev Cell. 2021 Oct 11;56(19):2692-2702.e5
pubmed: 34610328
Eur J Biochem. 2001 Feb;268(4):997-1005
pubmed: 11179966
J Biol Chem. 2000 Apr 14;275(15):10819-25
pubmed: 10753875
Sci Signal. 2016 Sep 20;9(446):ra92
pubmed: 27649739
Mol Cell. 2021 Jan 21;81(2):398-407.e4
pubmed: 33340489
Arch Biochem Biophys. 2011 Jan 15;505(2):250-5
pubmed: 20951114
Proteomics. 2006 Feb;6(4):1200-9
pubmed: 16421937
J Biol Chem. 2009 Dec 11;284(50):34777-84
pubmed: 19833729
Gastrointest Endosc. 2021 Oct;94(4):733-741.e4
pubmed: 33965384
Diabetologia. 1974 Apr;10(2):149-54
pubmed: 4152382
Exp Mol Med. 2022 May;54(5):553-566
pubmed: 35501376
Cell Metab. 2008 May;7(5):389-99
pubmed: 18460330
Biochemistry. 2010 Apr 20;49(15):3327-35
pubmed: 20307070
J Cell Biol. 2015 Mar 30;208(7):869-80
pubmed: 25825515
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62
pubmed: 22436748
Elife. 2013 May 21;2:e00429
pubmed: 23705068
Int J Mol Sci. 2015 Sep 22;16(9):22830-55
pubmed: 26402672
J Nutr. 2006 Jun;136(6 Suppl):1652S-1659S
pubmed: 16702335
Science. 2015 Jan 9;347(6218):194-8
pubmed: 25567907
Int J Neonatal Screen. 2020 Jul 29;6(3):
pubmed: 33239585
Diabetes Obes Metab. 2014 Sep;16 Suppl 1:26-32
pubmed: 25200293
Cell Metab. 2008 Dec;8(6):512-21
pubmed: 19041766
Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5279-E5288
pubmed: 29784813
J Biol Chem. 2009 Feb 6;284(6):3425-32
pubmed: 19073609
Semin Cell Dev Biol. 2012 Aug;23(6):631-9
pubmed: 22273692
Nature. 2011 Nov 20;481(7381):385-8
pubmed: 22101431
J Biol Chem. 2019 Jun 14;294(24):9342-9357
pubmed: 31040181
Science. 2017 Nov 10;358(6364):813-818
pubmed: 29123071
Biochem J. 2009 Apr 15;419(2):447-55
pubmed: 19138173
Nature. 2015 Jan 15;517(7534):302-10
pubmed: 25592535
J Lipid Res. 2013 Aug;54(8):2144-2152
pubmed: 23720822
Nat Cell Biol. 2021 Jan;23(1):7-8
pubmed: 33420487
J Biol Chem. 2008 May 9;283(19):13009-20
pubmed: 18353774
Nat Cell Biol. 2013 Jun;15(6):555-64
pubmed: 23728461
Adv Med Sci. 2019 Mar;64(1):104-110
pubmed: 30605863
Front Cell Dev Biol. 2020 Aug 11;8:715
pubmed: 32850834
Metabolites. 2021 Jan 31;11(2):
pubmed: 33572567
Cell Metab. 2014 Sep 2;20(3):526-40
pubmed: 25002183
Science. 2020 Jan 10;367(6474):205-210
pubmed: 31780625
Lipids. 1995 Jun;30(6):567-73
pubmed: 7651085
Curr Opin Clin Nutr Metab Care. 2009 Jan;12(1):54-8
pubmed: 19057188
Front Oncol. 2022 Mar 11;12:836058
pubmed: 35359351
Biochem Soc Trans. 2009 Apr;37(Pt 2):408-12
pubmed: 19290871
Cell Metab. 2019 Jun 4;29(6):1306-1319.e7
pubmed: 30956113
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19611-6
pubmed: 22106302
Endocr Rev. 2004 Oct;25(5):807-30
pubmed: 15466941
Cell. 2016 Mar 24;165(1):153-164
pubmed: 26972053
Nature. 2017 Mar 16;543(7645):433-437
pubmed: 28199315
Exp Mol Med. 2020 Sep;52(9):1496-1516
pubmed: 32943735
Cell Res. 2021 Apr;31(4):478-481
pubmed: 33349646
Nat Commun. 2017 Sep 29;8(1):732
pubmed: 28963468
FASEB J. 2019 Mar;33(3):4341-4354
pubmed: 30592630
Arch Biochem Biophys. 2019 Mar 15;663:199-213
pubmed: 30641049
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9545-9550
pubmed: 30181260
Mol Cell. 2012 Aug 10;47(3):349-58
pubmed: 22749528
Int J Mol Sci. 2017 May 12;18(5):
pubmed: 28498331
Trends Biotechnol. 2010 Sep;28(9):476-84
pubmed: 20691487
Annu Rev Nutr. 1999;19:379-406
pubmed: 10448530
Science. 2016 Jan 1;351(6268):43-8
pubmed: 26449471
J Biol Chem. 2011 May 20;286(20):18002-12
pubmed: 21454655
Cell Metab. 2019 Sep 3;30(3):508-524.e12
pubmed: 31204282
J Lipid Res. 2018 Jul;59(7):1084-1093
pubmed: 29627764
Cell Rep. 2021 Apr 27;35(4):109031
pubmed: 33910001
Diabetes. 2016 Sep;65(9):2711-23
pubmed: 27207534
Cell. 2002 Aug 23;110(4):489-500
pubmed: 12202038
Annu Rev Nutr. 2014;34:281-303
pubmed: 24850384