Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 05 05 2022
accepted: 25 04 2023
medline: 16 6 2023
pubmed: 1 6 2023
entrez: 31 5 2023
Statut: ppublish

Résumé

Each tumour contains diverse cellular states that underlie intratumour heterogeneity (ITH), a central challenge of cancer therapeutics

Identifiants

pubmed: 37258682
doi: 10.1038/s41586-023-06130-4
pii: 10.1038/s41586-023-06130-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

598-606

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Avishai Gavish (A)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Michael Tyler (M)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Alissa C Greenwald (AC)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Rouven Hoefflin (R)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Dor Simkin (D)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Roi Tschernichovsky (R)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel.

Noam Galili Darnell (N)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Einav Somech (E)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Chaya Barbolin (C)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Tomer Antman (T)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Daniel Kovarsky (D)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Thomas Barrett (T)

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, USA.
Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.

L Nicolas Gonzalez Castro (LN)

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.

Debdatta Halder (D)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Rony Chanoch-Myers (R)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Julie Laffy (J)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Michael Mints (M)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

Adi Wider (A)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Rotem Tal (R)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Avishay Spitzer (A)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Toshiro Hara (T)

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Maria Raitses-Gurevich (M)

The Oncology Institute, Chaim Sheba Medical Center, Ramat Gan, Israel.

Chani Stossel (C)

The Oncology Institute, Chaim Sheba Medical Center, Ramat Gan, Israel.
The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Talia Golan (T)

The Oncology Institute, Chaim Sheba Medical Center, Ramat Gan, Israel.
The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Amit Tirosh (A)

The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Division of Endocrinology, Diabetes and Metabolism, Chaim Sheba Medical Center, Ramat Gan, Israel.

Mario L Suvà (ML)

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Sidharth V Puram (SV)

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, USA.
Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.

Itay Tirosh (I)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. itay.tirosh@weizmann.ac.il.

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