Pancreatic duct lavage cytology combined with a cell-block method for patients with possible pancreatic ductal adenocarcinomas, including pancreatic carcinoma in situ.
Carcinoma in situ
Cell biology
Endoscopic retrograde cholangiopancreatography
Pancreatic juice
Pancreatic neoplasms
Journal
Clinical endoscopy
ISSN: 2234-2400
Titre abrégé: Clin Endosc
Pays: Korea (South)
ID NLM: 101576886
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
08
12
2021
accepted:
04
04
2022
medline:
1
6
2023
pubmed:
1
6
2023
entrez:
1
6
2023
Statut:
ppublish
Résumé
This study aimed to clarify the efficacy and safety of pancreatic duct lavage cytology combined with a cell-block method (PLC-CB) for possible pancreatic ductal adenocarcinomas (PDACs). This study included 41 patients with suspected PDACs who underwent PLC-CB mainly because they were unfit for undergoing endoscopic ultrasonography-guided fine needle aspiration. A 6-Fr double lumen catheter was mainly used to perform PLC-CB. Final diagnoses were obtained from the findings of resected specimens or clinical outcomes during surveillance after PLC-CB. Histocytological evaluations using PLC-CB were performed in 87.8% (36/41) of the patients. For 31 of the 36 patients, final diagnoses (invasive PDAC, 12; pancreatic carcinoma in situ, 5; benignancy, 14) were made, and the remaining five patients were excluded due to lack of surveillance periods after PLC-CB. For 31 patients, the sensitivity, specificity, and accuracy of PLC-CB for detecting malignancy were 94.1%, 100%, and 96.8%, respectively. In addition, they were 87.5%, 100%, and 94.1%, respectively, in 17 patients without pancreatic masses detectable using endoscopic ultrasonography. Four patients developed postprocedural pancreatitis, which improved with conservative therapy. PLC-CB has an excellent ability to detect malignancies in patients with possible PDACs, including pancreatic carcinoma in situ.
Sections du résumé
BACKGROUND/AIMS
OBJECTIVE
This study aimed to clarify the efficacy and safety of pancreatic duct lavage cytology combined with a cell-block method (PLC-CB) for possible pancreatic ductal adenocarcinomas (PDACs).
METHODS
METHODS
This study included 41 patients with suspected PDACs who underwent PLC-CB mainly because they were unfit for undergoing endoscopic ultrasonography-guided fine needle aspiration. A 6-Fr double lumen catheter was mainly used to perform PLC-CB. Final diagnoses were obtained from the findings of resected specimens or clinical outcomes during surveillance after PLC-CB.
RESULTS
RESULTS
Histocytological evaluations using PLC-CB were performed in 87.8% (36/41) of the patients. For 31 of the 36 patients, final diagnoses (invasive PDAC, 12; pancreatic carcinoma in situ, 5; benignancy, 14) were made, and the remaining five patients were excluded due to lack of surveillance periods after PLC-CB. For 31 patients, the sensitivity, specificity, and accuracy of PLC-CB for detecting malignancy were 94.1%, 100%, and 96.8%, respectively. In addition, they were 87.5%, 100%, and 94.1%, respectively, in 17 patients without pancreatic masses detectable using endoscopic ultrasonography. Four patients developed postprocedural pancreatitis, which improved with conservative therapy.
CONCLUSION
CONCLUSIONS
PLC-CB has an excellent ability to detect malignancies in patients with possible PDACs, including pancreatic carcinoma in situ.
Identifiants
pubmed: 37259244
pii: ce.2022.021
doi: 10.5946/ce.2022.021
pmc: PMC10244143
doi:
Types de publication
Journal Article
Langues
eng
Pagination
353-366Commentaires et corrections
Type : CommentIn
Références
J Gastroenterol. 2010 Aug;45(8):868-75
pubmed: 20177713
J Gastroenterol Hepatol. 2016 Oct;31(10):1783-1789
pubmed: 26865332
Gastrointest Endosc. 2016 Jan;83(1):17-28
pubmed: 26706297
Dig Endosc. 2012 May;24(3):168-74
pubmed: 22507091
Pancreas. 2012 May;41(4):523-9
pubmed: 22504379
Clin J Gastroenterol. 2017 Dec;10(6):541-545
pubmed: 28986726
Dig Dis Sci. 1997 Aug;42(8):1796-803
pubmed: 9286251
J Gastroenterol. 2013 Jul;48(7):866-73
pubmed: 23053424
Pancreatology. 2018 Dec;18(8):928-934
pubmed: 30143405
J Gastroenterol. 2010 Nov;45(11):1183-91
pubmed: 20607310
Clin Endosc. 2019 Nov;52(6):588-597
pubmed: 31744269
Gastrointest Endosc. 2017 May;85(5):1036-1046
pubmed: 27756613
Pancreatology. 2020 Sep;20(6):1164-1174
pubmed: 32800646
Gastrointest Endosc. 1991 May-Jun;37(3):383-93
pubmed: 2070995
Clin Endosc. 2021 Mar;54(2):261-268
pubmed: 32892519
Gastrointest Endosc. 2013 May;77(5):726-35
pubmed: 23290718
Clin Endosc. 2021 Mar;54(2):161-181
pubmed: 33761231
Endoscopy. 2014 Sep;46(9):799-815
pubmed: 25148137
Diagn Cytopathol. 1997 Oct;17(4):239-47
pubmed: 9316777