Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies.
PCOS
gut microbiota
polyphenol
prebiotic
probiotic
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
28 Jan 2023
28 Jan 2023
Historique:
received:
08
12
2022
revised:
24
01
2023
accepted:
24
01
2023
medline:
1
6
2023
pubmed:
1
6
2023
entrez:
1
6
2023
Statut:
epublish
Résumé
Polycystic Ovarian Syndrome (PCOS) comprises a set of symptoms that pose significant risk factors for various diseases, including type 2 diabetes, cardiovascular disease, and cancer. Effective and safe methods to treat all the pathological symptoms of PCOS are not available. The gut microbiota has been shown to play an essential role in PCOS incidence and progression. Many dietary plants, prebiotics, and probiotics have been reported to ameliorate PCOS. Gut microbiota shows its effects in PCOS via a number of mechanistic pathways including maintenance of homeostasis, regulation of lipid and blood glucose levels. The effect of gut microbiota on PCOS has been widely reported in animal models but there are only a few reports of human studies. Increasing the diversity of gut microbiota, and up-regulating PCOS ameliorating gut microbiota are some of the ways through which prebiotics, probiotics, and polyphenols work. We present a comprehensive review on polyphenols from natural origin, probiotics, and fecal microbiota therapy that may be used to treat PCOS by modifying the gut microbiota.
Identifiants
pubmed: 37259345
pii: ph16020197
doi: 10.3390/ph16020197
pmc: PMC9967581
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
PLoS One. 2016 Apr 19;11(4):e0153196
pubmed: 27093642
Sci Data. 2018 Nov 06;5:180222
pubmed: 30398469
Endocr J. 2019 Oct 28;66(10):859-870
pubmed: 31270279
Front Microbiol. 2019 Jun 18;10:1359
pubmed: 31275280
Mol Endocrinol. 2014 Aug;28(8):1221-38
pubmed: 24892638
Food Funct. 2018 Jan 24;9(1):541-551
pubmed: 29260181
Clin Immunol. 2015 Aug;159(2):154-62
pubmed: 25956531
PLoS One. 2017 Jan 3;12(1):e0168390
pubmed: 28045919
Horm Mol Biol Clin Investig. 2017 Feb 1;29(2):71-77
pubmed: 27802175
Virulence. 2017 Apr 3;8(3):342-351
pubmed: 27657355
J Nutr Biochem. 2018 Apr;54:87-94
pubmed: 29329013
Horm Behav. 2017 Feb;88:45-51
pubmed: 27816626
Br J Nutr. 2012 May;107(10):1429-34
pubmed: 21914236
Mol Med Rep. 2015 Jul;12(1):696-704
pubmed: 25738264
Iran J Med Sci. 2013 Mar;38(1):38-43
pubmed: 23645956
Ann Nutr Metab. 2014;65(1):34-41
pubmed: 25196301
Gut Pathog. 2014 Oct 15;6(1):43
pubmed: 25328543
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4775-4780
pubmed: 28420790
Br J Nutr. 2008 Feb;99(2):254-61
pubmed: 17711612
PLoS One. 2016 Jan 05;11(1):e0146509
pubmed: 26731268
Foods. 2019 Mar 09;8(3):
pubmed: 30857316
FEBS Open Bio. 2016 Jan 18;6(1):64-76
pubmed: 27047743
J Agric Food Chem. 2010 Apr 14;58(7):3977-83
pubmed: 20201554
J Mol Med (Berl). 2017 Jan;95(1):1-8
pubmed: 27900395
Nutrition. 2012 May;28(5):539-43
pubmed: 22129852
Int J Mol Sci. 2010 Jun 17;11(6):2499-522
pubmed: 20640165
Reprod Biol Endocrinol. 2019 Aug 16;17(1):67
pubmed: 31420039
BMC Endocr Disord. 2020 Jan 6;20(1):3
pubmed: 31906930
Clin Endocrinol (Oxf). 2014 Oct;81(4):588-92
pubmed: 24730585
Trends Endocrinol Metab. 2016 Sep;27(9):665-675
pubmed: 27474997
Mediators Inflamm. 2015;2015:326032
pubmed: 25944980
Br J Nutr. 2011 Mar;105(5):755-64
pubmed: 20974015
J Clin Microbiol. 2008 Apr;46(4):1551-2
pubmed: 18256229
Nutrients. 2020 Jun 12;12(6):
pubmed: 32545596
Dig Liver Dis. 2018 Jul;50(7):635-639
pubmed: 29650468
Nutrients. 2020 Nov 22;12(11):
pubmed: 33266362
Front Physiol. 2017 Aug 25;8:602
pubmed: 28890700
J Clin Invest. 2016 Dec 1;126(12):4430-4443
pubmed: 27775551
Eur J Endocrinol. 2015 Jan;172(1):11-20
pubmed: 25300285
Br J Nutr. 2010 Dec;104(12):1831-8
pubmed: 20815975
J Nutr. 2008 Apr;138(4):732-9
pubmed: 18356328
Am J Med Sci. 2009 Sep;338(3):174-7
pubmed: 19590426
Benef Microbes. 2018 Apr 25;9(3):441-452
pubmed: 29409330
Pestic Biochem Physiol. 2019 Sep;159:68-79
pubmed: 31400786
Biochem Biophys Res Commun. 2016 Nov 11;480(2):222-227
pubmed: 27746173
Eur J Nutr. 2018 Feb;57(1):1-24
pubmed: 28393285
Res Microbiol. 2019 Jan - Feb;170(1):43-52
pubmed: 30292647
Immune Netw. 2014 Dec;14(6):277-88
pubmed: 25550694
Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G900-10
pubmed: 24136789
Curr Opin Microbiol. 2013 Dec;16(6):779-85
pubmed: 24148302
Gut Microbes. 2018;9(5):400-421
pubmed: 29469650
Food Funct. 2014 Jun;5(6):1241-9
pubmed: 24722352
J Nutr. 2014 Aug;144(8):1181-7
pubmed: 24919690
Front Endocrinol (Lausanne). 2020 Jan 31;11:25
pubmed: 32082260
J Nutr Sci. 2015 May 04;4:e17
pubmed: 26090097
Front Cell Infect Microbiol. 2017 Mar 24;7:64
pubmed: 28393050
Physiology (Bethesda). 2016 Jul;31(4):283-93
pubmed: 27252163
J Med Food. 2018 May;21(5):454-461
pubmed: 29688793
J Endocr Soc. 2019 Jun 14;3(8):1545-1573
pubmed: 31384717
Trends Endocrinol Metab. 2019 Jan;30(1):54-65
pubmed: 30503354
Dig Liver Dis. 2015 Dec;47(12):1007-12
pubmed: 26257129
Food Funct. 2020 Jun 24;11(6):5192-5204
pubmed: 32441726
Science. 2012 Jun 8;336(6086):1314-7
pubmed: 22674328
J Res Med Sci. 2014 Jun;19(6):531-6
pubmed: 25197295
Fertil Steril. 2012 Jan;97(1):18-22
pubmed: 22192137
J Ovarian Res. 2018 Sep 14;11(1):80
pubmed: 30217229
World J Mens Health. 2020 Jan;38(1):48-60
pubmed: 30929328
Microorganisms. 2019 Jan 10;7(1):
pubmed: 30634578
Ann Nutr Metab. 2013;63(1-2):1-9
pubmed: 23899653
Int Immunol. 2021 Nov 25;33(12):761-766
pubmed: 34232990
Front Pharmacol. 2019 Nov 19;10:1360
pubmed: 31803054
Genet Res Int. 2018 Feb 18;2018:7624932
pubmed: 29670770
Front Microbiol. 2015 Sep 25;6:1014
pubmed: 26441937
J Clin Endocrinol Metab. 2018 Apr 1;103(4):1502-1511
pubmed: 29370410
Life Sci. 2021 Sep 1;280:119753
pubmed: 34171379
Gut. 2013 Jan;62(1):159-76
pubmed: 22730468
J Clin Endocrinol Metab. 2010 May;95(5):2038-49
pubmed: 20375205
Trends Microbiol. 2013 Jul;21(7):334-41
pubmed: 23685069
J Dairy Sci. 2011 Jul;94(7):3288-94
pubmed: 21700013
Gut Pathog. 2021 May 8;13(1):31
pubmed: 33964975
Microbiol Mol Biol Rev. 2007 Sep;71(3):495-548
pubmed: 17804669
Front Microbiol. 2021 Sep 28;12:711137
pubmed: 34650525
Int J Biol Macromol. 2017 Jun;99:282-292
pubmed: 28238909
DNA Cell Biol. 2019 Aug;38(8):754-762
pubmed: 31305133
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4268-73
pubmed: 24591617
Indian J Psychol Med. 2018 May-Jun;40(3):239-246
pubmed: 29875531
J Clin Endocrinol Metab. 2018 Jul 1;103(7):2552-2562
pubmed: 29897462
Clinics (Sao Paulo). 2015 Nov;70(11):765-9
pubmed: 26602525
PLoS One. 2014 Apr 14;9(4):e94687
pubmed: 24733124
Eur Rev Med Pharmacol Sci. 2013 Oct;17(20):2816-21
pubmed: 24174366
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21307-12
pubmed: 23151509
Br J Nutr. 2009 Jun;101(11):1679-87
pubmed: 19017418
Biochem J. 2017 May 16;474(11):1823-1836
pubmed: 28512250
FEMS Microbiol Rev. 2009 Jul;33(4):718-38
pubmed: 19207743
Iran J Basic Med Sci. 2020 Jan;23(1):36-45
pubmed: 32405346
J Transl Med. 2012 Dec 21;10:253
pubmed: 23259758
Gut Microbes. 2013 Jul-Aug;4(4):325-39
pubmed: 23842110
Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C438-C445
pubmed: 28249988
Endocrinology. 2019 May 1;160(5):1193-1204
pubmed: 30924862
BMC Microbiol. 2019 Mar 12;19(1):57
pubmed: 30871463
Liver Res. 2020 Jun;4(2):47-63
pubmed: 34290896
Food Funct. 2019 May 22;10(5):2947-2957
pubmed: 31073553
Sci Rep. 2015 Oct 12;5:14600
pubmed: 26455903
Immunity. 2016 Apr 19;44(4):889-900
pubmed: 27084119
Sci Rep. 2018 Nov 20;8(1):17135
pubmed: 30459320
PLoS One. 2019 Sep 30;14(9):e0223274
pubmed: 31568518
Dig Liver Dis. 2018 May;50(5):421-428
pubmed: 29567414
Chem Biol Interact. 2022 Dec 1;368:110238
pubmed: 36306865
Int J Reprod Biomed. 2018 Mar;16(3):149-158
pubmed: 29766146
Eur J Obstet Gynecol Reprod Biol. 2016 Feb;197:136-41
pubmed: 26751822
Microbiome. 2020 Sep 20;8(1):136
pubmed: 32951609
Nutrients. 2020 May 19;12(5):
pubmed: 32438689
J Neurogastroenterol Motil. 2018 Jul 30;24(3):367-386
pubmed: 29969855
Sci Rep. 2014 May 06;4:4855
pubmed: 24798184
Gut Microbes. 2012 Jul-Aug;3(4):289-306
pubmed: 22572875
Front Microbiol. 2018 Aug 14;9:1835
pubmed: 30154767
PLoS One. 2019 Sep 11;14(9):e0206484
pubmed: 31509535
Ann Hepatol. 2017 Nov;16 Suppl 1:S21-S26
pubmed: 31196631
J Ovarian Res. 2018 Apr 3;11(1):26
pubmed: 29615083
J Nutr. 2018 Feb 1;148(2):209-219
pubmed: 29490092
Molecules. 2016 Oct 25;21(11):
pubmed: 27792146
FEMS Microbiol Rev. 2011 May;35(3):475-97
pubmed: 21204864
Endocr J. 2016;63(1):93-100
pubmed: 26607017
Scand J Gastroenterol. 2008;43(7):831-41
pubmed: 18584522
Med Hypotheses. 2021 Sep;154:110644
pubmed: 34332209
Nutr Cancer. 2017 Aug-Sep;69(6):943-951
pubmed: 28718724
Am J Clin Nutr. 2017 Jan;105(1):127-135
pubmed: 28049662
Ther Adv Endocrinol Metab. 2020 Jul 6;11:2042018820938305
pubmed: 32670541
Front Pharmacol. 2020 Apr 30;11:554
pubmed: 32425790
Diabetes. 2007 Jul;56(7):1761-72
pubmed: 17456850
Mol Syst Biol. 2010 Jul;6:392
pubmed: 20664638
Benef Microbes. 2014 Dec;5(4):437-45
pubmed: 25062610
Front Microbiol. 2016 Aug 19;7:1204
pubmed: 27594848
Clin Med Insights Reprod Health. 2019 Dec 27;13:1179558119890867
pubmed: 31908561
PLoS One. 2012;7(7):e40888
pubmed: 22808282
Front Endocrinol (Lausanne). 2020 May 27;11:284
pubmed: 32670195
Endocr Connect. 2020 Jan;9(1):63-73
pubmed: 31972546
Nutr Metab Cardiovasc Dis. 2014 Jan;24(1):57-64
pubmed: 23831006
Anaerobe. 2017 Apr;44:13-19
pubmed: 28077337
J Biol Chem. 2013 Aug 30;288(35):25088-25097
pubmed: 23836895
Nutrients. 2017 Jan 03;9(1):
pubmed: 28054937
Arch Iran Med. 2018 Jan 01;21(1):1-7
pubmed: 29664663
Gut. 1998 Feb;42(2):266-71
pubmed: 9536953
Int J Environ Res Public Health. 2018 Nov 20;15(11):
pubmed: 30463276
Diabetes Care. 2015 May;38(5):930-3
pubmed: 25678103
Sci Rep. 2016 Aug 10;6:31208
pubmed: 27506289
Front Microbiol. 2019 Feb 08;10:175
pubmed: 30800111
Front Microbiol. 2017 Feb 28;8:324
pubmed: 28293234
Eur J Nutr. 2017 Jun;56(4):1535-1550
pubmed: 26988693
Nutrients. 2015 Apr 16;7(4):2930-46
pubmed: 25894657
Genome Med. 2013 Jul 30;5(7):63
pubmed: 23899327
Pharmacol Res. 2020 Sep;159:104954
pubmed: 32492490
Cell Mol Gastroenterol Hepatol. 2015 Mar;1(2):222-232
pubmed: 26405687
Genome Res. 2011 Oct;21(10):1616-25
pubmed: 21880779
Int J Mol Sci. 2016 Jun 13;17(6):
pubmed: 27304953
Sci Transl Med. 2009 Nov 11;1(6):6ra14
pubmed: 20368178
J Endocr Soc. 2020 Nov 16;5(2):bvaa177
pubmed: 33381671
Front Immunol. 2019 Mar 11;10:277
pubmed: 30915065
Front Behav Neurosci. 2019 Jun 18;13:126
pubmed: 31275120
Ther Clin Risk Manag. 2008 Apr;4(2):487-92
pubmed: 18728832
Res Microbiol. 2019 Jun - Aug;170(4-5):192-201
pubmed: 30940469
Environ Microbiol. 2021 Jun;23(6):3037-3047
pubmed: 33876556
Nature. 2016 Jul 21;535(7612):376-81
pubmed: 27409811
Front Immunol. 2020 Sep 10;11:2184
pubmed: 33013918
Obstet Gynecol Sci. 2013 May;56(3):137-42
pubmed: 24327994
Med Hypotheses. 2012 Jul;79(1):104-12
pubmed: 22543078
Nutrients. 2019 Sep 13;11(9):
pubmed: 31540270
Front Immunol. 2019 Mar 07;10:385
pubmed: 30899262
Pharmaceutics. 2022 Nov 06;14(11):
pubmed: 36365213
Clin Nutr. 2012 Oct;31(5):735-40
pubmed: 22444236
Microb Ecol Health Dis. 2015 Feb 02;26:26191
pubmed: 25651997
Nat Rev Immunol. 2014 Jun;14(6):405-16
pubmed: 24854590
Top Spinal Cord Inj Rehabil. 2019 Summer;25(3):228-240
pubmed: 31548790
BMC Endocr Disord. 2018 Apr 12;18(1):21
pubmed: 29649996
Nat Med. 2018 Apr 10;24(4):392-400
pubmed: 29634682
Reprod Sci. 2016 Sep;23(9):1242-9
pubmed: 26917422
J Ovarian Res. 2020 Jun 17;13(1):73
pubmed: 32552864
J Cell Biochem. 2014 Nov;115(11):1996-2003
pubmed: 24924355
mSystems. 2019 Apr 16;4(2):
pubmed: 31020040
Pediatr Res. 2015 Jan;77(1-2):229-35
pubmed: 25303277
Fertil Steril. 2020 Jun;113(6):1286-1298.e4
pubmed: 32482258
New Microbes New Infect. 2018 Mar 20;24:4-7
pubmed: 29922468
Oncotarget. 2015 Oct 13;6(31):30545-56
pubmed: 26437083
Nat Med. 2013 May;19(5):576-85
pubmed: 23563705
PLoS One. 2012;7(3):e34233
pubmed: 22457829
PLoS One. 2015 Jul 10;10(7):e0126976
pubmed: 26161548
Dev Comp Immunol. 2019 Oct;99:103399
pubmed: 31195052
Biomed Res Int. 2017;2017:9351507
pubmed: 29230419
Histochem Cell Biol. 2017 Jul;148(1):85-93
pubmed: 28265783
Gut Microbes. 2020 Nov 9;12(1):1-28
pubmed: 32845788
Maturitas. 2018 Oct;116:43-53
pubmed: 30244778
Mol Cell Proteomics. 2016 Mar;15(3):1007-16
pubmed: 26637539
Bioprocess Biosyst Eng. 2021 May;44(5):953-964
pubmed: 32157446
Nat Med. 2019 Aug;25(8):1225-1233
pubmed: 31332392
PLoS Med. 2016 Nov 29;13(11):e1002179
pubmed: 27898682