In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [

glycogen synthase kinase 3 non-human primates positron emission tomography radiopharmaceutical

Journal

Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453

Informations de publication

Date de publication:
28 Jan 2023
Historique:
received: 07 12 2022
revised: 21 01 2023
accepted: 24 01 2023
medline: 1 6 2023
pubmed: 1 6 2023
entrez: 1 6 2023
Statut: epublish

Résumé

Glycogen synthase kinase 3 (GSK-3) is a potential therapeutic target for a range of neurodegenerative and psychiatric disorders. The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [

Identifiants

pubmed: 37259346
pii: ph16020194
doi: 10.3390/ph16020194
pmc: PMC9959234
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIDA NIH HHS
ID : P30 DA046345
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG052414
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG054473
Pays : United States

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Auteurs

Kelly Smart (K)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON M5T 1R8, Canada.
Department of Psychiatry, University of Toronto, 250 College St., Toronto, ON M5T 1R8, Canada.
Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.

Ming-Qiang Zheng (MQ)

Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.

Daniel Holden (D)

Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.

Zachary Felchner (Z)

Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.

Li Zhang (L)

Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.

Yanjiang Han (Y)

Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.
Nanfang Hospital, Southern Medical University, 1838 Guangzhou Blvd North, Guangzhou 510515, China.

Jim Ropchan (J)

Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.

Richard E Carson (RE)

Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.

Neil Vasdev (N)

Brain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON M5T 1R8, Canada.
Department of Psychiatry, University of Toronto, 250 College St., Toronto, ON M5T 1R8, Canada.

Yiyun Huang (Y)

Yale PET Center, Yale School of Medicine, 801 Howard Ave., New Haven, CT 06519, USA.

Classifications MeSH