Hedgehog signaling regulates bone homeostasis through orchestrating osteoclast differentiation and osteoclast-osteoblast coupling.
Bone loss
CTGF
CTSK
OVX
SMO/GLI2 axis
TRAF6
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
01 Jun 2023
01 Jun 2023
Historique:
received:
03
01
2023
accepted:
22
05
2023
revised:
08
05
2023
medline:
5
6
2023
pubmed:
1
6
2023
entrez:
1
6
2023
Statut:
epublish
Résumé
Imbalance of bone homeostasis induces bone degenerative diseases such as osteoporosis. Hedgehog (Hh) signaling plays critical roles in regulating the development of limb and joint. However, its unique role in bone homeostasis remained largely unknown. Here, we found that canonical Hh signaling pathway was gradually augmented during osteoclast differentiation. Genetic inactivation of Hh signaling in osteoclasts, using Ctsk-Cre;Smo
Identifiants
pubmed: 37261512
doi: 10.1007/s00018-023-04821-9
pii: 10.1007/s00018-023-04821-9
doi:
Substances chimiques
Hedgehog Proteins
0
TNF Receptor-Associated Factor 6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
171Subventions
Organisme : National Natural Science Foundation of China
ID : 81772377
Organisme : National Natural Science Foundation of China
ID : 81871743
Organisme : National Natural Science Foundation of China
ID : 81902202
Organisme : National Natural Science Foundation of China
ID : 82130070
Organisme : Key Research and Development Projects of Shaanxi Province
ID : 2021SF-024
Organisme : Innovation Team Projects-Innovation Capability Support Program of Shaanxi Province
ID : 2020TD-036
Organisme : Clinical Medical Research Center Projects-Innovation Capability Support Program of Shaanxi Province
ID : 2020LCZX-03
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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