New perspectives in diabetic neuropathy.
bioenergetics
diabetes
dyslipidemia
hyperglycemia
metabolic syndrome
mitochondria
obesity
pathophysiology
peripheral neuropathy
prediabetes
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
06 09 2023
06 09 2023
Historique:
received:
18
02
2023
revised:
20
04
2023
accepted:
03
05
2023
pmc-release:
06
09
2024
medline:
11
9
2023
pubmed:
2
6
2023
entrez:
1
6
2023
Statut:
ppublish
Résumé
Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D), which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy (DPN), the most common microvascular complication, is length-dependent damage to peripheral nerves. DPN pathogenesis is complex, but, at its core, it can be viewed as a state of impaired metabolism and bioenergetics failure operating against the backdrop of long peripheral nerve axons supported by glia. This unique peripheral nerve anatomy and the injury consequent to T2D underpins the distal-to-proximal symptomatology of DPN. Earlier work focused on the impact of hyperglycemia on nerve damage and bioenergetics failure, but recent evidence additionally implicates contributions from obesity and dyslipidemia. This review will cover peripheral nerve anatomy, bioenergetics, and glia-axon interactions, building the framework for understanding how hyperglycemia and dyslipidemia induce bioenergetics failure in DPN. DPN and painful DPN still lack disease-modifying therapies, and research on novel mechanism-based approaches is also covered.
Identifiants
pubmed: 37263266
pii: S0896-6273(23)00345-8
doi: 10.1016/j.neuron.2023.05.003
pmc: PMC10525009
mid: NIHMS1904714
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2623-2641Subventions
Organisme : NINDS NIH HHS
ID : F32 NS011024
Pays : United States
Organisme : Medical Research Council
ID : MR/W002388/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK129320
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS123450
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063608
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK130913
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS111024
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK119366
Pays : United States
Organisme : NIDDK NIH HHS
ID : K99 DK119366
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests D.L.B. has acted as a consultant in the last 2 years for AditumBio, Amgen, Biointervene, Bristows, LatigoBio, GSK, Ionis, Lexicon therapeutics, Neuvati, Olipass, Orion, Replay, Third Rock Ventures, and Vida Ventures on behalf of Oxford University Innovation. D.L.B. has received research funding from Lilly and Astra Zeneca.
Références
Diabetologia. 2001 Nov;44(11):1973-88
pubmed: 11719828
Expert Rev Endocrinol Metab. 2010 Jan 1;5(1):39-49
pubmed: 20729997
Nat Rev Neurol. 2023 Jan;19(1):53-64
pubmed: 36400867
J Neurosci. 2019 May 8;39(19):3770-3781
pubmed: 30886017
Diabetes. 2003 Oct;52(10):2615-22
pubmed: 14514647
Cells. 2020 Mar 27;9(4):
pubmed: 32230947
Lancet Neurol. 2022 Oct;21(10):922-936
pubmed: 36115364
Diabetes. 2020 Mar;69(3):448-464
pubmed: 31882567
J Neuroinflammation. 2021 May 6;18(1):106
pubmed: 33952299
Diabetes Res Clin Pract. 2018 May;139:147-154
pubmed: 29518491
Am J Transl Res. 2020 May 15;12(5):1714-1727
pubmed: 32509171
PLoS One. 2013 Oct 22;8(10):e77986
pubmed: 24167592
PLoS One. 2018 Feb 6;13(2):e0192333
pubmed: 29408929
Antioxid Redox Signal. 2009 Mar;11(3):425-38
pubmed: 19072199
Pain. 2021 Jun 1;162(6):1816-1827
pubmed: 33979318
Pain Physician. 2022 Nov;25(8):E1163-E1173
pubmed: 36375183
Diabetes Obes Metab. 2017 Oct;19(10):1468-1472
pubmed: 28332276
J Cell Sci. 2018 Jul 26;131(14):
pubmed: 29930087
J Peripher Nerv Syst. 2002 Mar;7(1):44-53
pubmed: 11939351
Diabetes Care. 2020 Mar;43(3):683-690
pubmed: 31932459
PLoS Biol. 2019 Jul 18;17(7):e3000363
pubmed: 31318874
JAMA Netw Open. 2019 May 3;2(5):e194798
pubmed: 31150078
J Diabetes Investig. 2018 Nov;9(6):1239-1254
pubmed: 29533535
Ann Clin Transl Neurol. 2022 Sep;9(9):1392-1404
pubmed: 35923113
J Diabetes Complications. 2016 Jan-Feb;30(1):30-7
pubmed: 26525588
BMC Med Inform Decis Mak. 2022 May 29;22(1):144
pubmed: 35644620
Diabetes. 2019 Apr;68(4):796-806
pubmed: 30617218
Sci Rep. 2018 Feb 7;8(1):2579
pubmed: 29416111
Physiol Rev. 2018 Oct 1;98(4):2133-2223
pubmed: 30067154
Clin Auton Res. 2019 Aug;29(4):443-455
pubmed: 31076938
Am J Clin Nutr. 2000 Jan;71(1 Suppl):386S-92S
pubmed: 10618002
J Neurol Sci. 2004 Feb 15;217(2):157-63
pubmed: 14706218
Sci Rep. 2022 Mar 18;12(1):4729
pubmed: 35304484
Obes Surg. 2021 Feb;31(2):554-563
pubmed: 33104989
Lancet. 2022 Nov 19;400(10365):1803-1820
pubmed: 36332637
Theranostics. 2021 Jun 1;11(15):7491-7506
pubmed: 34158863
Diabetologia. 2022 Jun;65(6):1048-1057
pubmed: 35275239
Ann Neurol. 2012 Sep;72(3):406-18
pubmed: 23034913
Exp Neurol. 2020 Nov;333:113415
pubmed: 32717355
Brain. 2011 Nov;134(Pt 11):3222-35
pubmed: 21926103
Cell Rep. 2018 Oct 9;25(2):271-277.e4
pubmed: 30304667
Life Sci. 2018 Jul 15;205:54-62
pubmed: 29750992
Dis Model Mech. 2017 Jun 1;10(6):717-725
pubmed: 28381495
Mol Cell Neurosci. 2016 Apr;72:46-53
pubmed: 26802537
Nature. 2023 Feb;614(7946):118-124
pubmed: 36697822
Neuron. 2020 Sep 23;107(6):1141-1159.e7
pubmed: 32735781
Nat Commun. 2022 Jan 10;13(1):181
pubmed: 35013299
PLoS One. 2022 Feb 17;17(2):e0263831
pubmed: 35176062
Muscle Nerve. 2021 Mar;63(3):285-293
pubmed: 33098165
Mol Metab. 2019 Feb;20:149-165
pubmed: 30545741
J Clin Endocrinol Metab. 2022 Mar 24;107(4):1091-1109
pubmed: 34878536
J Pharmacol Exp Ther. 2019 Mar;368(3):535-544
pubmed: 30602591
Mol Neurobiol. 2022 Mar;59(3):1836-1849
pubmed: 35023058
Br J Nutr. 1987 May;57(3):383-93
pubmed: 3109464
Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652):
pubmed: 25135971
FASEB J. 2018 Jan;32(1):195-207
pubmed: 28904018
Neuron. 2016 Jul 6;91(1):119-32
pubmed: 27292539
Nat Commun. 2020 May 26;11(1):2624
pubmed: 32457287
Biochim Biophys Acta. 2013 Jan;1828(1):69-78
pubmed: 22326946
Diabetes. 2015 Sep;64(9):3294-304
pubmed: 25979075
FASEB J. 2021 Jul;35(7):e21712
pubmed: 34110637
Nat Neurosci. 2014 Oct;17(10):1351-61
pubmed: 25195104
Nat Rev Dis Primers. 2019 Jun 13;5(1):41
pubmed: 31197153
Diabetologia. 2016 Jun;59(6):1297-306
pubmed: 27000313
J Neurocytol. 1992 Sep;21(9):623-34
pubmed: 1403008
Naunyn Schmiedebergs Arch Pharmacol. 2009 May;379(5):445-52
pubmed: 19139849
Diabetes. 2009 Oct;58(10):2376-85
pubmed: 19592619
JCI Insight. 2022 Dec 8;7(23):
pubmed: 36477360
Diabetes Care. 2017 Jan;40(1):136-154
pubmed: 27999003
Biochim Biophys Acta Bioenerg. 2022 Jun 1;1863(5):148545
pubmed: 35339437
Cochrane Database Syst Rev. 2012 Jun 13;(6):CD007543
pubmed: 22696371
Diabetes Res Clin Pract. 2019 Nov;157:107843
pubmed: 31518657
Neurology. 2022 Jan 4;98(1):31-43
pubmed: 34965987
J Neurosci. 2021 May 12;41(19):4321-4334
pubmed: 33785643
Neurobiol Dis. 2022 Aug;170:105751
pubmed: 35569720
Dis Model Mech. 2020 Jan 24;13(2):
pubmed: 31822493
J Lipid Res. 2019 Jan;60(1):58-70
pubmed: 30442656
Brain. 2021 Jun 22;144(5):1312-1335
pubmed: 34128530
JCI Insight. 2016 Sep 22;1(15):e86976
pubmed: 27699244
Nat Commun. 2020 May 21;11(1):2552
pubmed: 32439942
Diabetologia. 2020 Aug;63(8):1648-1658
pubmed: 32537727
Cells. 2020 Aug 29;9(9):
pubmed: 32872454
Diabetologia. 2021 Jun;64(6):1412-1421
pubmed: 33768284
Annu Rev Cell Dev Biol. 2013;29:355-84
pubmed: 24099085
Neurology. 2017 Jun 13;88(24):2294-2301
pubmed: 28515269
Diabetologia. 2005 Mar;48(3):578-85
pubmed: 15729579
Diabet Med. 2023 Jan;40(1):e14890
pubmed: 35616949
Front Neurosci. 2021 Mar 03;15:636172
pubmed: 33746703
Neurosci Lett. 2014 Feb 7;560:81-5
pubmed: 24370596
Antioxid Redox Signal. 2010 Sep 15;13(6):757-68
pubmed: 20136508
Diabetes Care. 2018 May;41(5):1068-1075
pubmed: 29487078
Cell. 2014 Jul 3;158(1):54-68
pubmed: 24995978
Methods Mol Biol. 2022;2486:247-276
pubmed: 35437727
J Cell Sci. 2020 Jun 15;133(12):
pubmed: 32409566
Eur J Pain. 2022 Nov;26(10):2198-2212
pubmed: 36069121
Ann Clin Transl Neurol. 2018 Feb 14;5(4):397-405
pubmed: 29687018
Epigenetics. 2019 Aug;14(8):766-779
pubmed: 31132961
Front Endocrinol (Lausanne). 2018 Sep 06;9:522
pubmed: 30237786
Diabetologia. 2022 Apr;65(4):620-631
pubmed: 35048156
Antioxid Redox Signal. 2011 May 15;14(10):1829-39
pubmed: 21194385
Pain. 2016 Aug;157(8):1599-1606
pubmed: 27115670
J Peripher Nerv Syst. 2004 Mar;9(1):26-53
pubmed: 14871451
Sci Transl Med. 2017 Sep 27;9(409):eaam6072
pubmed: 28954930
Biochem Biophys Res Commun. 2015 Jan 9;456(2):615-20
pubmed: 25498543
J Inherit Metab Dis. 2010 Oct;33(5):469-77
pubmed: 20195903
Diabetes. 2020 Oct;69(10):2157-2169
pubmed: 32763913
Nat Rev Neurol. 2020 Dec;16(12):689-705
pubmed: 33110213
JAMA Neurol. 2021 Jun 1;78(6):687-698
pubmed: 33818600
Neural Regen Res. 2019 Aug;14(8):1335-1342
pubmed: 30964051
Neuron. 2012 Feb 23;73(4):638-52
pubmed: 22365541
Diabetes Metab. 2022 Jul;48(4):101331
pubmed: 35172198
FASEB J. 2021 May;35(5):e21467
pubmed: 33788970
Mol Pharmacol. 2018 Nov;94(5):1256-1269
pubmed: 30135145
Ann Surg. 2013 Nov;258(5):760-5; discussion 765-6
pubmed: 23979278
Metabolism. 1996 Dec;45(12):1466-73
pubmed: 8969278
Glia. 2020 Jan;68(1):161-177
pubmed: 31453649
Diabetes Care. 2019 Feb;42(2):240-247
pubmed: 30523031
FASEB J. 2002 Nov;16(13):1738-48
pubmed: 12409316
FASEB J. 2005 Apr;19(6):638-40
pubmed: 15677696
Int Rev Neurobiol. 2019;145:177-209
pubmed: 31208524
Nature. 2012 Apr 29;485(7399):517-21
pubmed: 22622581
Diabetes. 2019 Nov;68(11):2120-2130
pubmed: 31439642
Pediatr Diabetes. 2021 Mar;22(2):132-147
pubmed: 33205601
Int J Mol Sci. 2021 May 05;22(9):
pubmed: 34063061
Diabetes. 2010 Apr;59(4):1082-91
pubmed: 20103706
Diabetes Care. 2017 Sep;40(9):1226-1232
pubmed: 28674076
J Cell Biol. 2012 Jul 9;198(1):127-41
pubmed: 22753894
Lancet. 2009 May 23;373(9677):1780-8
pubmed: 19465233
Circ Res. 2010 Oct 29;107(9):1058-70
pubmed: 21030723
Lancet. 2018 Jun 16;391(10138):2449-2462
pubmed: 29916386
Sci Rep. 2018 Dec 5;8(1):17678
pubmed: 30518872
J Mol Neurosci. 2001 Apr-Jun;16(2-3):133-42; discussion 151-7
pubmed: 11478368
Diabetes Metab J. 2013 Oct;37(5):375-84
pubmed: 24199167
Biology (Basel). 2020 Oct 22;9(11):
pubmed: 33105667
Exp Neurol. 2019 Oct;320:112967
pubmed: 31145897
Diabetes Metab Syndr. 2022 Sep;16(9):102603
pubmed: 36049390
Mol Pain. 2019 Jan-Dec;15:1744806919849802
pubmed: 31041876
Pain. 2019 Nov;160(11):2497-2507
pubmed: 31219946
Front Pharmacol. 2021 Aug 31;12:670389
pubmed: 34531738
Antioxid Redox Signal. 2022 Sep;37(7-9):613-630
pubmed: 34861780
J Peripher Nerv Syst. 2017 Sep;22(3):162-171
pubmed: 28485482
Glia. 2013 Nov;61(11):1795-806
pubmed: 24038411
Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E242-53
pubmed: 18577699
PLoS One. 2014 Jan 02;9(1):e83204
pubmed: 24392081
Brain. 2021 Jul 28;144(6):1632-1645
pubmed: 33711103
Diabetes Res Clin Pract. 2022 Jan;183:109119
pubmed: 34879977
Nat Genet. 2020 Jul;52(7):680-691
pubmed: 32541925
Diabetologia. 2023 Jul;66(7):1192-1207
pubmed: 36917280
Sci Rep. 2019 Jan 29;9(1):881
pubmed: 30696927
Lancet. 2022 Aug 27;400(10353):680-690
pubmed: 36007534
Pain. 2016 May;157(5):1132-1145
pubmed: 27088890
Neurobiol Dis. 2021 Jul;155:105392
pubmed: 34000416
Endocr Rev. 2018 Oct 1;39(5):629-663
pubmed: 30060120
Diabetes. 2020 Apr;69(4):749-759
pubmed: 31915154
Diabetes. 2020 Sep;69(9):1974-1988
pubmed: 32647036
Semin Immunol. 2022 Jan;59:101628
pubmed: 35779975
Neurol Neuroimmunol Neuroinflamm. 2021 Nov 11;9(1):
pubmed: 34764216
Front Mol Neurosci. 2022 May 20;15:856299
pubmed: 35668789
Diabetes Care. 2020 Dec;43(12):2945-2952
pubmed: 32998990
Clin Epigenetics. 2020 Aug 12;12(1):123
pubmed: 32787975
Pain. 2022 Mar 1;163(3):560-578
pubmed: 34232927
Diabetes Care. 2019 Dec;42(12):2282-2289
pubmed: 31558545
J Neurosci. 2008 Apr 9;28(15):4047-56
pubmed: 18400904
Nature. 2012 Jul 26;487(7408):443-8
pubmed: 22801498
Front Physiol. 2022 Aug 22;13:921942
pubmed: 36072849
J Neurochem. 2008 Jan;104(2):491-9
pubmed: 17995925
Rev Diabet Stud. 2015 Spring-Summer;12(1-2):13-28
pubmed: 26676659
J Physiol. 2003 Jan 15;546(Pt 2):551-64
pubmed: 12527741
JAMA Netw Open. 2021 Dec 1;4(12):e2136560
pubmed: 34854908
J Peripher Nerv Syst. 2017 Jun;22(2):112-120
pubmed: 28429469
Exp Neurol. 2018 Jul;305:33-43
pubmed: 29550371
Neuroreport. 2018 Aug 1;29(11):945-953
pubmed: 29877948
Diabetes Care. 2020 Jun;43(6):1266-1275
pubmed: 32295810
Diabetes Care. 2011 Oct;34(10):2220-4
pubmed: 21852677
Nat Med. 2012 Jun;18(6):926-33
pubmed: 22581285
Int J Mol Sci. 2020 Dec 24;22(1):
pubmed: 33374137
J Transl Sci. 2021 Feb;7(1):
pubmed: 33868719
Eur J Pharmacol. 2018 Aug 15;833:472-523
pubmed: 29966615
FASEB J. 2018 Jun 22;:fj201800597R
pubmed: 29932869
iScience. 2022 Sep 15;25(10):105141
pubmed: 36204278
Nat Neurosci. 2020 Oct;23(10):1215-1228
pubmed: 32807950
PLoS One. 2022 Oct 4;17(10):e0272097
pubmed: 36194565
Diabetes. 2013 Mar;62(3):944-52
pubmed: 23364451
PLoS Biol. 2020 Dec 22;18(12):e3000621
pubmed: 33351792
Int Rev Neurobiol. 2019;145:127-176
pubmed: 31208522
Pain. 2018 Nov;159(11):2339-2346
pubmed: 30015707
PLoS Biol. 2013 Jul;11(7):e1001604
pubmed: 23874151
Ann Clin Transl Neurol. 2021 Jun;8(6):1292-1307
pubmed: 33955722
J Lipid Res. 2018 Feb;59(2):173-183
pubmed: 29237716
Brain. 2018 Feb 1;141(2):357-364
pubmed: 29346515
Obesity (Silver Spring). 2021 Dec;29(12):2108-2118
pubmed: 34747574
Diabetes. 2006 Feb;55(2):341-8
pubmed: 16443766
J Mol Biol. 2018 Oct 19;430(21):3922-3941
pubmed: 30089235
Mol Metab. 2021 Jan;43:101114
pubmed: 33166742
Exp Neurol. 2015 Jan;263:325-38
pubmed: 25447940
Int J Mol Sci. 2022 Jun 28;23(13):
pubmed: 35806193
Lancet Neurol. 2020 Aug;19(8):699-710
pubmed: 32445622
Lancet Neurol. 2015 Feb;14(2):162-73
pubmed: 25575710
Diabetes Metab Syndr Obes. 2018 Apr 09;11:117-127
pubmed: 29674850
J Clin Invest. 2011 Apr;121(4):1402-11
pubmed: 21403394
Pain. 2022 Apr 1;163(4):682-689
pubmed: 34252910
Antioxid Redox Signal. 2014 Aug 1;21(4):588-600
pubmed: 23991914
Lab Invest. 2003 Feb;83(2):175-85
pubmed: 12594233
Handb Clin Neurol. 2014;126:469-87
pubmed: 25410240
Neuron. 2017 Mar 22;93(6):1296-1313
pubmed: 28334605
Pain. 2018 Mar;159(3):469-480
pubmed: 29176367
Glia. 2021 Jan;69(1):124-136
pubmed: 32686211
Diabet Med. 2021 Feb;38(2):e14376
pubmed: 32738821
Front Neurosci. 2016 Dec 23;10:581
pubmed: 28066166
Curr Diab Rep. 2015 Nov;15(11):89
pubmed: 26370700