Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration.
Journal
npj aging
ISSN: 2731-6068
Titre abrégé: NPJ Aging
Pays: England
ID NLM: 9918402285106676
Informations de publication
Date de publication:
01 Jun 2023
01 Jun 2023
Historique:
received:
16
01
2023
accepted:
04
05
2023
medline:
2
6
2023
pubmed:
2
6
2023
entrez:
1
6
2023
Statut:
epublish
Résumé
Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering the elderly more susceptible to dehydration. Chronically, vasopressin has been associated with numerous diseases of old age, including type 2 diabetes and metabolic syndrome. Bulk RNAseq transcriptome analysis has been used to catalogue the polyadenylated supraoptic nucleus transcriptomes of adult (3 months) and aged (18 months) rats in basal euhydrated and stimulated dehydrated conditions. Gene ontology and Weighted Correlation Network Analysis revealed that ageing is associated with alterations in the expression of extracellular matrix genes. Interestingly, whilst the transcriptomic response to dehydration is overall blunted in aged animals compared to adults, there is a specific enrichment of differentially expressed genes related to neurodegenerative processes in the aged cohort, suggesting that dehydration itself may provoke degenerative consequences in aged rats.
Identifiants
pubmed: 37264028
doi: 10.1038/s41514-023-00108-2
pii: 10.1038/s41514-023-00108-2
pmc: PMC10234251
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12Subventions
Organisme : British Heart Foundation
ID : FS/17/60/33474
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N022807/1
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
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